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Migraine/Chronic Headache in pregnancy

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Migraine and Pregnancy

  • Migraine will often improve during pregnancy.
  • Migraine may change to migrainous aura without headache
  • Maximise non-drug therapies (trigger avoidance, adequate sleep/nutrition/hydration, rest with symptoms)
  • Drug therapies: Bottom line – avoid them all except paracetamol/NSAID unless really necessary. See figures takenfrom Amundsen, S. et. al. Nat. Reviews Neurol. 11, 209–219 (2015); doi:10.1038/nrneurol.2015.29 Also available on Refhelp
  • Note that Valproate is now contraindicated in women of childbearing age for migraine.

Richard Davenport and Jon Stone, Neurology, Jan 2021

Migraine and Pregnancy

  • Migraine will often improve during pregnancy.
  • Migraine may change to migrainous aura without headache
  • Maximise non-drug therapies (trigger avoidance, adequate sleep/nutrition/hydration, rest with symptoms)
  • Drug therapies: Bottom line – avoid them all except paracetamol/NSAID unless really necessary. See figures takenfrom Amundsen, S. et. al. Nat. Reviews Neurol. 11, 209–219 (2015); doi:10.1038/nrneurol.2015.29 Also available on Refhelp
  • Note that Valproate is now contraindicated in women of childbearing age for migraine.

Richard Davenport and Jon Stone, Neurology, Jan 2021