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Iron Deficiency Anaemia

Key messages

  • ​Iron deficiency anaemia is defined as a low haemoglobin in the presence of either
  • Low ferritin (best diagnostic marker)
  • Low serum iron in the presence of transferrin >3.0
  • The prevalence of iron deficiency anaemia amongst adult males and non-menstruating females in the developed world is approximately 2-5%
  • Iron deficiency anaemia can arise as a consequence of
    • Loss of iron (menstrual blood loss, GI blood loss, renal tract blood loss)
    • Malabsorption (previous gastric surgery, Coeliac disease)
    • Poor dietary iron intake (poor diet, lifestyle choices or cultural beliefs)
    • May be contributing factors:
      • Menstrual blood loss is the commonest cause overall
      • Testing for Coeliac disease (anti tTG antibodies) is worthwhile

NOTE THAT IRON AND TRANSFERRIN SHOULD BE DONE ON A FASTING SAMPLE

Investigating Iron Deficiency Anaemia.jpg

In the presence of true, proven iron deficiency, approximately 10% of males and non- menstruating females will have a significant GI problem underlying this.

  • These individuals should be referred for appropriate GI investigations if they are sufficiently fit to undergo them
  • Investigation of the upper and lower GI tract will be undertaken
    • Upper GI Endoscopy combined with either
    • Colonoscopy or CT colonography or minimal preparation CT scan
  • Appropriate investigation will be at the discretion of the secondary care team and will depend on a patient’s age and general fitness (which may have to be determined by clinic visit first)
    • CT colonography will be offered to less fit patients or those who cannot tolerate colonoscopy*
    • Minimal prep CT (no purgative laxative preparation) will be reserved for the most frail patients where any investigation at all is appropriate*
    • *It would be useful to have up to date U&E’s for frail patients or those >80 years

GI investigations are not appropriate in other types of anaemia unless there are clear GI symptoms to be investigated

  • Menstruating females should not undergo GI investigation in the absence of GI symptoms or a family history of colon cancer
    • Testing for Coeliac disease is appropriate in these patients
  • GI investigations may be appropriate for patients >50 years (and without history of menorrhagia) with proven iron deficiency in the absence of anaemia

​Males and non-menstruating females who have Iron Deficiency Anaemia, in the absence of GI symptoms, should be referred using the Iron deficiency Anaemia pathway via Gastroenterology.