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Isolated Rise in ALT in Asymptomatic AdultsALT is a sensitive marker of hepatocyte injury.
- However considerable liver injury may be present with normal transaminase levels.
- Serum ALT activity varies with age, sex, race, body mass index, acute illness and exercise.
- There is poor correlation between the level of rise of ALT and biopsy findings. A persistently abnormal ALT should have some investigation performed.
- If ALT
remains abnormal after a period of observation and first line
investigation reveals no clear cause then a referral (biopsy) threshold
of >200 can be used.
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