Suspicious Pigmented Lesions and Changing Melanocytic Naevi

Patients often present with new or changing occasionally symptomatic pigmented lesions.
It is normal for new naevi to develop until the age of 40 – referral should be based on suspicion of malignancy

Diagnostics Tips

Malignant melanoma may be a new lesion or develop in a pre-existing mole
Amelanotic malignant melanoma may present as an enlarging, granulating or smooth pink nodule. Beware the solitary pink papule!
Assess risk factors:
- high sun exposure
- family history of melanoma
- presence of atypical naevi
- Changing naevus with suspicious ABCDE signs:
  - Asymmetry
  - Irregular Border
  - Colour Variation
  - Increasing Diameter
  - Evolution-changing features
  - Be suspicious of the “ugly duckling” mole that doesn’t look like its neighbours!

superficial spreading melanoma — DermNet (dermnetnz.org) Superficial spreading melanoma

nodular melanoma — DermNet (dermnetnz.org) Superficial spreading melanoma

acral lentiginous malignant melanoma — DermNet (dermnetnz.org) Acral lentiginous malignant melanoma in heel

However these signs are not diagnostic and you should refer any lesion you feel may be malignant.

Acral-lentiginous melanoma

Melanocytic naevi and melanomas may occur under nails and on the palms of hands/soles of feet. Sub-ungual melanocytic lesions usually appear as a symmetrical pigmented band that starts at the base of the nail but does not involve the nail fold

The presence of pigment in the nail fold (“Hutchinson’s Sign”), ulceration or destruction of the nail plate or an asymmetrical/wide band are all highly suspicious for melanoma.

All images on this page are sourced from DermNet | Dermatology Resource (dermnetnz.org)

R.C 25-04-24

Suspected malignant melanoma

Refer via “Urgent Suspicious Pigmented Lesion (Melanoma)” dermatology referral pathway and mark letter accordingly.
If you have a high suspicion that the lesion may be a melanoma then tick the “high suspicion of melanoma” box.
If it is a mole that you think is unlikely to be a melanoma but would like a specialist opinion on, then tick the “low suspicion of melanoma but wish to exclude diagnosis” box. Note that ALL referrals will be dealt with under the Scottish USOC pathway timeframe irrespective of whichever level of risk is chosen.
Attach photo if available and appropriate data protection guidelines adhered to.

Any patient who has a malignant melanoma removed in primary care must be referred urgently under the above pathway