
Current Projects
We have a broad and exciting portfolio of diverse research projects from essential basic science to cutting edge clinical trials
OUR PROJECTS

STRIVE
An open-label dose-escalating study evaluating the safety, pharmacokinetics and antiviral activity of IMC-M113V in HLA-A*02:01 positive, virologically suppressed subjects with chronic HIV infection

Fluent
A Phase 3, Randomized, Observer-blind, Active-controlled Study to Investigate the Safety, Reactogenicity, and Efficacy of mRNA-1010 Candidate Seasonal Influenza Vaccine Compared with a Licensed Inactivated Seasonal Influenza Vaccine in Adults ≥50 Years of Age

Nova 301
A Phase 3, Randomized, Observer-blinded, Placebo-Controlled Study to Evaluate the Safety and Efficacy of mRNA-1403, a Multivalent Candidate Vaccine to Prevent Norovirus Acute Gastroenteritis in Adults ≥18 Years of Age

SNAP
Staphylococcus aureus Network Adaptive Platform trial

B-WELL 1
Phase 3 Multicenter, Randomized, Double-Blind, Study to Assess the Efficacy and Safety of Treatment with Bepirovirsen in HBeAg_negative Nucleos(t)ide Analogue-treated Participants with Chronic Hepatitis B Virus

UKAR
UK Antimicrobial Registry

Define AP3
Define Appendix 3 (VST Therapy)

MIDAS
Measuring the impact of Improved Diagnostics on Antimicrobial Stewardship in Respiratory Tract Infection

Odyssey
Phase 1/2, randomized, observer-blind, dose-ranging study to evaluate the safety, reactogenicity, and immunogenicity of mRNA-1018 pandemic influenza candidate vaccines in healthy adults ≥18 years of age

MISTRAL
Microbiome-based stratification of individuals at risk of HIV-1 acquisition, chronic clinical complications, antimicrobial drug resistance, and unresponsiveness to therapeutic HIV-1 vaccination

CASCADE
An investigation into the medical and lived experiences of people with recently acquired HIV in Europe and Canada

SUPERNOVA
Study Understanding Pre-Exposure pRophylaxis of NOVel Antibodies (SUPERNOVA)

NEXTCOVE
A randomised, observer-blind, active-controlled Phase 3 study to investigate the safety, immunogenicity, and relative vaccine efficacy of mRNA-1283.222 administered as a booster dose compared with mRNA-1273.222 in participants aged 12 years and older for the prevention of COVID-19

RECOVERY
Randomised Evaluation of COVID-19 Therapy

PANORAMIC
Platform Adaptive trial of NOvel antiviRals for eArly treatMent of covid-19 In the Community

RIO
A randomised placebo controlled trial of ART plus dual long-acting HIV-specific broadly neutralising antibodies (bNAbs) vs ART plus placebo in treated Primary HIV Infection on viral control off ART

EuroSIDA
The EuroSIDA network 2005-2009. Clinical and virological outcome of patients with HIV in Europe

DexEnceph
Dexamethasone in Herpes Simplex Virus Encephalitis Randomised Controlled Trial and Non-HSV Cohort Study

VIBRANT
Vaccine Immunity Breakthrough & Re-Infection – ANtibody & T-cells

PrEPaRe
Pre-exposure Prophylaxis Use in People Newly Diagnosed with HIV

IONOE
Improving Outcomes of Necrotising Otitis Externa

TIDE
A multi-centre, randomised controlled, non-inferiority and cost effectiveness trial comparing Polyhexanide and Chlorhexidine with Neomycin to Mupirocin for nasal methicillin-resistant Staphylococcus aureus (MRSA) decolonisation amongst adult hospital in-patients

HEAL-COVID
HElping Alleviate the Longer-term consequences of COVID-19 (HEAL-COVID)

ISARIC 4C
ISARIC/WHO Clinical Characterisation Protocol for Severe Emerging Infections in the UK (CCP-UK) (Scotland)
OUR MEMBERS
Inspiring projects require inspiring teams. We encourage you to find out more about our incredible CIRG professionals.