{"id":4178,"date":"2022-05-03T11:47:20","date_gmt":"2022-05-03T10:47:20","guid":{"rendered":"https:\/\/apps.nhslothian.scot\/refhelp\/guidelines\/neutrophilia\/"},"modified":"2023-08-31T14:22:27","modified_gmt":"2023-08-31T13:22:27","slug":"neutrophilia","status":"publish","type":"page","link":"https:\/\/apps.nhslothian.scot\/refhelp\/guidelines\/haematology\/neutrophilia\/","title":{"rendered":"Neutrophilia"},"content":{"rendered":"\n<title>Neutrophilia<\/title>\n\n\n\n<h4 class=\"wp-block-heading\">Definition <\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Increase in neutrophils on FBC differential.&nbsp; <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Neutrophilia is frequently &#8216;reactive&#8217;, associated with acute infection\/active inflammation or acute stress eg acute bleed.&nbsp; Haematological causes possible with significant persistent increase over 1-2 months in the absence of underlying reactive cause.&nbsp; Blood film comments may show circulating immature forms eg myelocytes\/nucleated red cells or aniso\/poikilocytosis.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>C.M &amp; L.W 31-07-23<\/strong><\/p>\n\n\n\n<div class=\"wp-block-getwid-tabs\" data-active-tab=\"0\"><ul class=\"wp-block-getwid-tabs__nav-links\"><\/ul>\n<div class=\"wp-block-getwid-tabs__nav-link\"><span class=\"wp-block-getwid-tabs__title-wrapper\"><a href=\"#\"><span class=\"wp-block-getwid-tabs__title\">Referral Guidelines<\/span><\/a><\/span><\/div><div class=\"wp-block-getwid-tabs__tab-content-wrapper\"><div class=\"wp-block-getwid-tabs__tab-content\">\n<h4 class=\"wp-block-heading\">Who to refer:<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Patients with significant persistent neutrophilia &gt;15 after 4-6 weeks with any of the following:<strong><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>no obvious cause such as inflammation<\/li>\n\n\n\n<li>additional abnormalities on blood film comments, eg presence of myelocytes or nucleated red cells or significant poikilocytosis<\/li>\n\n\n\n<li>significant anaemia or thrombocytosis\/thrombocytopenia<\/li>\n\n\n\n<li>blood count\/film reported as suggestive of chronic myeloid leukaemia<\/li>\n\n\n\n<li>splenomegaly.<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Who not to refer:<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Transient neutrophilia or persistent mild neutrophilia &lt;15.&nbsp; This is most likely caused by chronic inflammatory or infective processes. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">May be associated with smoking.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">How to refer:<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">SCI Gateway to the Department of Haematology at WGH or St John\u2019s.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-getwid-tabs__nav-link\"><span class=\"wp-block-getwid-tabs__title-wrapper\"><a href=\"#\"><span class=\"wp-block-getwid-tabs__title\">Primary Care Management<\/span><\/a><\/span><\/div><div class=\"wp-block-getwid-tabs__tab-content-wrapper\"><div class=\"wp-block-getwid-tabs__tab-content\">\n<h3 class=\"wp-block-heading\">Primary care investigations<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>FBC + film<\/li>\n\n\n\n<li>Biochemistry including renal function, liver function, LDH calcium, albumin, urate<\/li>\n\n\n\n<li>Inflammatory markers, ESR, CRP<\/li>\n\n\n\n<li>Check smoking history including e-cigarettes.<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-getwid-tabs__nav-link\"><span class=\"wp-block-getwid-tabs__title-wrapper\"><a href=\"#\"><span class=\"wp-block-getwid-tabs__title\">Resources and Links<\/span><\/a><\/span><\/div><div class=\"wp-block-getwid-tabs__tab-content-wrapper\"><div class=\"wp-block-getwid-tabs__tab-content\">\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n<\/div><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Neutrophilia Definition Increase in neutrophils on FBC differential.&nbsp; Neutrophilia is frequently &lsquo;reactive&rsquo;, associated with acute infection\/active inflammation or acute stress eg acute bleed.&nbsp; Haematological causes possible with significant persistent increase over 1-2 months in the absence of underlying reactive cause.&nbsp; Blood film comments may show circulating immature forms eg myelocytes\/nucleated red cells or aniso\/poikilocytosis. C.M<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":3981,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_searchwp_excluded":"","footnotes":""},"categories":[268],"class_list":["post-4178","page","type-page","status-publish","hentry","category-neutrophilia"],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"rttpg_featured_image_url":null,"rttpg_author":{"display_name":"NHS Lothian","author_link":"https:\/\/apps.nhslothian.scot\/refhelp\/author\/nhs-lothian\/"},"rttpg_comment":0,"rttpg_category":" <a href=\"https:\/\/apps.nhslothian.scot\/refhelp\/category\/haematology\/neutrophilia\/\" rel=\"tag\">Neutrophilia<\/a>","rttpg_excerpt":"Neutrophilia Definition Increase in neutrophils on FBC differential.&nbsp; Neutrophilia is frequently &lsquo;reactive&rsquo;, associated with acute infection\/active inflammation or acute stress eg acute bleed.&nbsp; Haematological causes possible with significant persistent increase over 1-2 months in the absence of underlying reactive cause.&nbsp; Blood film comments may show circulating immature forms eg myelocytes\/nucleated red cells or aniso\/poikilocytosis. C.M","_links":{"self":[{"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/pages\/4178","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/comments?post=4178"}],"version-history":[{"count":6,"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/pages\/4178\/revisions"}],"predecessor-version":[{"id":16151,"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/pages\/4178\/revisions\/16151"}],"up":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/pages\/3981"}],"wp:attachment":[{"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/media?parent=4178"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/categories?post=4178"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}