{"id":3742,"date":"2022-05-03T11:47:20","date_gmt":"2022-05-03T10:47:20","guid":{"rendered":"https:\/\/apps.nhslothian.scot\/refhelp\/guidelines\/breast-disease-men\/"},"modified":"2026-03-23T08:23:08","modified_gmt":"2026-03-23T08:23:08","slug":"breast-disease-men","status":"publish","type":"page","link":"https:\/\/apps.nhslothian.scot\/refhelp\/guidelines\/breastdisease\/breast-disease-men\/","title":{"rendered":"Breast Disease in Men"},"content":{"rendered":"\n<p>Gynaecomastia is a breast manifestation of a systemic problem. Secondary care referral and investigation is not necessary in the vast majority of cases.<\/p>\n\n\n\n<p>Breast lumps in men (rather than generalised breast swelling), or other suspicious features such as nipple inversion, nipple discharge or distortion should be referred to the Breast Unit as USC \u2013 please see guidance on <a href=\"https:\/\/apps.nhslothian.scot\/refhelp\/guidelines\/breastdisease\/breastlump\/\" target=\"_blank\" rel=\"noreferrer noopener\">RefHelp Breast Lump page<\/a> and\/or <a href=\"https:\/\/apps.nhslothian.scot\/refhelp\/guidelines\/breastdisease\/nipplesymptoms\/\" target=\"_blank\" rel=\"noreferrer noopener\">RefHelp Nipple Symptoms page<\/a>.<\/p>\n\n\n\n<p>The vast majority of referrals referred to EBU as men with breast lumps are found to have gynaecomastia. It is therefore recommended that in most cases where referral is being arranged, gynaecomastia bloods are arranged either prior to referral, or at point of referral. <\/p>\n\n\n\n<p class=\"has-alert-red-color has-text-color has-link-color wp-elements-eaa4e50cbac0c42b15e43b974280c20b\"><strong>However, if the clinical picture is clearly suggestive of a likely breast cancer then waiting for bloods should NOT delay referral.<\/strong><\/p>\n\n\n\n<p>Published data has shown that transgender women have a higher risk of breast cancer compared to men, and transgender men have a lower risk of breast cancer compared to women. In transgender women the risk of breast cancer is associated with hormone treatment. In cases of gender reassignment, it is important to provide sensitive and clinically appropriate care depending on individual circumstances and considering any hormone therapy involved. <em>(Scottish Referral Guidelines for Suspected Cancer July 2025)<\/em><\/p>\n\n\n\n<p><strong>Referrals to the Breast Unit for men with USC are triaged in the same way and to the same timescale as USC referrals to the Breast Unit for women are triaged.<\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Gynaecomastia<\/h4>\n\n\n\n<p>Gynaecomastia is common, may be unilateral and is due to an imbalance of sex hormones.<\/p>\n\n\n\n<p>Causes include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Physiological: puberty, old age<\/li>\n\n\n\n<li>Pharmacological: Alcohol, cannabis, opiates, steroids, protein supplements, antiandrogens, digoxin, spironolactone, omeprazole, allopurinol and many others.<\/li>\n\n\n\n<li>Systemic illness: Liver disease, renal disease, testicular issues, obesity, previous radiotherapy or chemotherapy<\/li>\n<\/ul>\n\n\n\n<p class=\"has-alert-red-color has-text-color has-link-color wp-elements-d0e1cab0a2c5fdd2590a5a630de3d979\"><strong>As per the&nbsp;<\/strong><a href=\"https:\/\/eur01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.gov.scot%2Fbinaries%2Fcontent%2Fdocuments%2Fgovscot%2Fpublications%2Fadvice-and-guidance%2F2025%2F08%2Fscottish-referral-guidelines-suspected-cancer-2025%2Fdocuments%2Fscottish-referral-guidelines-suspected-cancer-2025%2Fscottish-referral-guidelines-suspected-cancer-2025%2Fgovscot%253Adocument%2Fscottish-referral-guidelines-suspected-cancer-2025.pdf&amp;data=05%7C02%7Cjane.burnett%40nhs.scot%7C35496e6764d74f14c91c08de00e9afa8%7C10efe0bda0304bca809cb5e6745e499a%7C0%7C0%7C638949201091834380%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&amp;sdata=vpPzoEqxbK4bfmGpXkkMxClAb6uiW%2B0RPnKtjEFnWKs%3D&amp;reserved=0\"><strong>SRGSC 2025 Gynaecomastia<\/strong><\/a><strong>&nbsp;can be a feature of germ cell tumours. See below re examination and investigation to help rule out testicular cancer as a cause.<\/strong><\/p>\n\n\n\n<p>Predisposing causes can be address in Primary Care, and do not need referral to Breast Unit<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Assessment<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Examine: <\/strong>Rule out discrete lumps or lymphadenopathy (that would require referral) rather than general swelling of breast tissue. Look for signs of systemic illness associated with gynaecomastia.<\/li>\n\n\n\n<li><strong>Testicular examination should be performed to look for atrophy, absence or lump<\/strong><\/li>\n<\/ul>\n\n\n\n<p>If no obvious cause is found then consider blood tests for:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Cr+Es, LFTs, LH, FSH, oestradiol, testosterone, prolactin, beta-HCG, AFP, TFTs<\/li>\n\n\n\n<li>In Primary Care can use grouped tests in ICE by selecting Gynaecomastia under the Endocrinology Tab. Only Cr+Es will need to be added on to this list.<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Management<\/h4>\n\n\n\n<p>In those with persistent swelling, not improved by addressing underlying factors, and who wish intervention then medication can be trialled:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Tamoxifen 10mg once daily for 3-9 months<\/li>\n\n\n\n<li>Anastrozole 1mg daily for 3 months<\/li>\n<\/ul>\n\n\n\n<p>This is an unlicensed indication. It is most useful for recent onset gynaecomastia and usually improves breast sensitivity.&nbsp; If prescription of a medication outwith its licensed indication is being considered, discussion with secondary care is an option, should this be felt necessary for the small number of patients who may benefit.&nbsp;<\/p>\n\n\n\n<p>Surgical intervention is considered via the exceptional aesthetic referral pathway via Plastic Surgery.<\/p>\n\n\n\n<p>Please see this helpful video from CfSD about <a href=\"https:\/\/www.youtube.com\/watch?v=kuMxdq1m-ZM\" target=\"_blank\" rel=\"noreferrer noopener\">Breast Lesions in Men<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Breast Lumps in Men<\/h4>\n\n\n\n<p>Men with a breast lump (with or without gynaecomastia) should be referred to Breast Clinic. Those with a clinically obvious lipoma may not need further investigation.<\/p>\n\n\n\n<p><strong>OY, LP &amp; JB MAR 26<\/strong><\/p>\n\n\n\n<div class=\"wp-block-getwid-tabs\" data-active-tab=\"0\"><ul class=\"wp-block-getwid-tabs__nav-links\"><\/ul>\n<div class=\"wp-block-getwid-tabs__nav-link\"><span class=\"wp-block-getwid-tabs__title-wrapper\"><a href=\"#\"><span class=\"wp-block-getwid-tabs__title\">Referral Guidelines<\/span><\/a><\/span><\/div><div class=\"wp-block-getwid-tabs__tab-content-wrapper\"><div class=\"wp-block-getwid-tabs__tab-content\">\n<h4 class=\"wp-block-heading\">Who to refer:<\/h4>\n\n\n\n<p><\/p>\n\n\n\n<p class=\"has-alert-red-color has-text-color has-link-color wp-elements-61d24da57e3d1cc29a7607e9616b6b9f\"><strong>Urgent Referral<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Men with breast lumps or other suspicious features should be referred as USC<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Who not to refer:<\/h4>\n\n\n\n<p><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Gynaecomastia without discrete lumps (though advice can be sought for those patients in whom medication is being considered)<\/li>\n\n\n\n<li>Those for who surgery is being considered \u2013 they should be referred to Plastic Surgery as detailed above<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">How to refer:<\/h4>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>Edinburgh, Midlothian and East Lothian Patients<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>For men with breast lumps please refer via SCI Gateway to WGH<\/li>\n<\/ul>\n\n\n\n<p>Western General Hospital &gt;&gt; General Surgery \u2013 Breast &gt;&gt; LI Breast Disease in Men (USC priority)<br>Western General Hospital &gt;&gt; General Surgery \u2013 Breast &gt;&gt; LI Breast \u2013 Urgent<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>For advice such as prescribing for Gynaecomastia please use advice pathway<\/li>\n<\/ul>\n\n\n\n<p>Western General Hospital &gt;&gt; General Surgery \u2013 Breast &gt;&gt; LI Breast \u2013 Advice only<\/p>\n\n\n\n<p><strong>West Lothian Patients<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>For men with breast lumps please refer via SCI Gateway to SJH<\/li>\n<\/ul>\n\n\n\n<p>St John\u2019s Hospital &gt;&gt; General Surgery \u2013 Breast &gt;&gt; LI Breast Disease in Men (USC priority)<br>St John\u2019s Hospital &gt;&gt; General Surgery \u2013 Breast &gt;&gt; LI Breast \u2013 Urgent<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>For advice such as prescribing for Gynaecomastia please use advice pathway<\/li>\n<\/ul>\n\n\n\n<p>St John\u2019s Hospital &gt;&gt; General Surgery \u2013 Breast &gt;&gt; LI Breast \u2013 Advice only<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-getwid-tabs__nav-link\"><span class=\"wp-block-getwid-tabs__title-wrapper\"><a href=\"#\"><span class=\"wp-block-getwid-tabs__title\">Primary Care Management<\/span><\/a><\/span><\/div><div class=\"wp-block-getwid-tabs__tab-content-wrapper\"><div class=\"wp-block-getwid-tabs__tab-content\">\n<p>See main page<\/p>\n\n\n\n<p>Please see this helpful video from the CfSD re <a href=\"https:\/\/www.youtube.com\/watch?v=kuMxdq1m-ZM\" target=\"_blank\" rel=\"noreferrer noopener\">Breast Lesions in Men<\/a><\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-getwid-tabs__nav-link\"><span class=\"wp-block-getwid-tabs__title-wrapper\"><a href=\"#\"><span class=\"wp-block-getwid-tabs__title\">Resources and Links<\/span><\/a><\/span><\/div><div class=\"wp-block-getwid-tabs__tab-content-wrapper\"><div class=\"wp-block-getwid-tabs__tab-content\">\n<p><a href=\"https:\/\/www.gov.scot\/binaries\/content\/documents\/govscot\/publications\/advice-and-guidance\/2025\/08\/scottish-referral-guidelines-suspected-cancer-2025\/documents\/scottish-referral-guidelines-suspected-cancer-2025\/scottish-referral-guidelines-suspected-cancer-2025\/govscot%3Adocument\/scottish-referral-guidelines-suspected-cancer-2025.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Scottish Referral Guidelines for Suspected Cancer 2025<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/www.nhscfsd.co.uk\/media\/2b1d3pav\/nhs-scotland-gynaecomastic-pathway-v1-9-august-2023.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">CfSD Modernising Patient Pathways Programme: Gynaecomastia<\/a><\/p>\n<\/div><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Gynaecomastia is a breast manifestation of a systemic problem. Secondary care referral and investigation is not necessary in the vast majority of cases. Breast lumps in men (rather than generalised breast swelling), or other suspicious features such as nipple inversion, nipple discharge or distortion should be referred to the Breast Unit as USC &ndash; please<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":3744,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"categories":[51],"class_list":["post-3742","page","type-page","status-publish","hentry","category-breast-disease-in-men"],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"rttpg_featured_image_url":null,"rttpg_author":{"display_name":"NHS Lothian","author_link":"https:\/\/apps.nhslothian.scot\/refhelp\/author\/nhs-lothian\/"},"rttpg_comment":0,"rttpg_category":" <a href=\"https:\/\/apps.nhslothian.scot\/refhelp\/category\/breastdisease\/breast-disease-in-men\/\" rel=\"tag\">Breast Disease in Men<\/a>","rttpg_excerpt":"Gynaecomastia is a breast manifestation of a systemic problem. Secondary care referral and investigation is not necessary in the vast majority of cases. Breast lumps in men (rather than generalised breast swelling), or other suspicious features such as nipple inversion, nipple discharge or distortion should be referred to the Breast Unit as USC &ndash; please","_links":{"self":[{"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/pages\/3742","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/comments?post=3742"}],"version-history":[{"count":17,"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/pages\/3742\/revisions"}],"predecessor-version":[{"id":27338,"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/pages\/3742\/revisions\/27338"}],"up":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/pages\/3744"}],"wp:attachment":[{"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/media?parent=3742"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/categories?post=3742"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}