{"id":17726,"date":"2023-12-12T12:27:08","date_gmt":"2023-12-12T12:27:08","guid":{"rendered":"https:\/\/apps.nhslothian.scot\/refhelp\/?page_id=17726"},"modified":"2026-10-08T13:30:09","modified_gmt":"2026-10-08T12:30:09","slug":"recurrent-oral-herpes-simplex-virus-hsv-infection","status":"publish","type":"page","link":"https:\/\/apps.nhslothian.scot\/refhelp\/guidelines\/infectiousdiseases\/recurrent-oral-herpes-simplex-virus-hsv-infection\/","title":{"rendered":"Recurrent Oral Herpes Simplex Virus (HSV) Infection"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Prophylactic oral antiviral treatment should be considered if the patient is:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>immunocompromised and has troublesome recurrent oral herpes simplex infection<\/li>\n\n\n\n<li>has&nbsp;frequent (6 or more episodes in one year), persistent and\/or&nbsp;severe episodes of recurrent&nbsp;oral herpes simplex infection<\/li>\n\n\n\n<li>has herpes simplex associated with recurrent erythema multiforme.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Those with atypical lesions or in whom the diagnosis is uncertain (but thought to be benign) \u00a0should be referred routinely to <a href=\"https:\/\/apps.nhslothian.scot\/refhelp\/guidelines\/dentistryoralhealthservice\/oralmedicine\/\" target=\"_blank\" rel=\"noreferrer noopener\">Oral Medicine<\/a>. <mark style=\"background-color:#ffffff\" class=\"has-inline-color has-alert-red-color\">Patients with unexplained ulceration of the oral mucosa persisting &gt; 3 weeks should be referred as urgent, suspicious of cancer to <\/mark><a href=\"https:\/\/apps.nhslothian.scot\/refhelp\/guidelines\/oralmaxillofacialsurgery\/\" target=\"_blank\" rel=\"noreferrer noopener\">Oral and Maxillofacial Surgery<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Severe or recurrent genital HSV infection should be referred to <a href=\"https:\/\/apps.nhslothian.scot\/refhelp\/guidelines\/sexualreprohealth\/sexuallytransmittedinfectionssti\/recurrent-genital-herpes-simplex\/\" target=\"_blank\" rel=\"noreferrer noopener\">Sexual and Reproductive Health Services<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>C.M &amp; N.B &#8211; 5-10-26<\/strong><\/p>\n\n\n\n<div class=\"wp-block-getwid-tabs\" data-active-tab=\"0\"><ul class=\"wp-block-getwid-tabs__nav-links\"><\/ul>\n<div class=\"wp-block-getwid-tabs__nav-link\"><span class=\"wp-block-getwid-tabs__title-wrapper\"><a href=\"#\"><span class=\"wp-block-getwid-tabs__title\">Referral Guidelines<\/span><\/a><\/span><\/div><div class=\"wp-block-getwid-tabs__tab-content-wrapper\"><div class=\"wp-block-getwid-tabs__tab-content\">\n<h4 class=\"wp-block-heading\"><strong>Who to refer:<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Patients with confirmed recurrent non-genital HSV infection which does not respond to first line prophylactic oral antiviral therapy.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Immunocompromised patients with recurrent non-genital HSV infection.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>Who not to refer:<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Patients with<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>atypical lesions or where the diagnosis is uncertain, but thought to be benign \u2013 refer to Oral Medicine<\/li>\n\n\n\n<li>unexplained ulceration of the oral mucosa persisting &gt; 3 weeks \u2013 refer to OMFS as urgent, suspicious of cancer.<\/li>\n\n\n\n<li>severe or recurrent genital HSV infection \u2013 refer to <a href=\"https:\/\/apps.nhslothian.scot\/refhelp\/guidelines\/sexualreprohealth\/sexuallytransmittedinfectionssti\/recurrent-genital-herpes-simplex\/\" target=\"_blank\" rel=\"noreferrer noopener\">Recurrent Genital Herpes<\/a> guidance.<\/li>\n\n\n\n<li>recurrent (6 or more episodes per year) uncomplicated HSV infection with no history of immunocompromise \u2013 start first line prophylactic antivirals as per BNF<\/li>\n\n\n\n<li>recurrence of HSV infection following cessation of prophylaxis \u2013 patients can be restarted on prophylaxis without further discussion.<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>How to refer:<\/strong> <\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Via Sci Gateway to Infectious Diseases at the Western General Hospital<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-getwid-tabs__nav-link\"><span class=\"wp-block-getwid-tabs__title-wrapper\"><a href=\"#\"><span class=\"wp-block-getwid-tabs__title\">Primary Care Management<\/span><\/a><\/span><\/div><div class=\"wp-block-getwid-tabs__tab-content-wrapper\"><div class=\"wp-block-getwid-tabs__tab-content\">\n<p class=\"wp-block-paragraph\">Guidance on the management of uncomplicated oral HSV is available as a NICE <a href=\"https:\/\/cks.nice.org.uk\/topics\/herpes-simplex-oral\/\" target=\"_blank\" rel=\"noreferrer noopener\">CKS summary<\/a>.&nbsp; Patients should be offered screening for HIV infection. Prophylactic treatment regimens for recurrent HSV infection can be found in the BNF.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em>In immunocompetent patients, the first line treatment is aciclovir 400mg twice daily. Breakthrough infections should be treated with standard courses of antiviral therapy before reverting to prophylactic dose.<\/em><\/strong><\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-getwid-tabs__nav-link\"><span class=\"wp-block-getwid-tabs__title-wrapper\"><a href=\"#\"><span class=\"wp-block-getwid-tabs__title\">Resources and Links<\/span><\/a><\/span><\/div><div class=\"wp-block-getwid-tabs__tab-content-wrapper\"><div class=\"wp-block-getwid-tabs__tab-content\">\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/cks.nice.org.uk\/topics\/herpes-simplex-oral\/\" target=\"_blank\" data-type=\"link\" data-id=\"https:\/\/cks.nice.org.uk\/topics\/herpes-simplex-oral\/\" rel=\"noreferrer noopener\">https:\/\/cks.nice.org.uk\/topics\/herpes-simplex-oral\/<\/a><\/p>\n<\/div><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Prophylactic oral antiviral treatment should be considered if the patient is: Those with atypical lesions or in whom the diagnosis is uncertain (but thought to be benign) &nbsp;should be referred routinely to Oral Medicine. Patients with unexplained ulceration of the oral mucosa persisting &gt; 3 weeks should be referred as urgent, suspicious of cancer to<\/p>\n","protected":false},"author":6,"featured_media":0,"parent":4043,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_searchwp_excluded":"","footnotes":""},"categories":[1057],"class_list":["post-17726","page","type-page","status-publish","hentry","category-https-apps-nhslothian-scot-refhelp-recurrent-oral-herpes-simplex-virus-hsv-infection"],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"rttpg_featured_image_url":null,"rttpg_author":{"display_name":"heatherlevy","author_link":"https:\/\/apps.nhslothian.scot\/refhelp\/author\/heatherlevy\/"},"rttpg_comment":0,"rttpg_category":" <a href=\"https:\/\/apps.nhslothian.scot\/refhelp\/category\/infectiousdiseases\/https-apps-nhslothian-scot-refhelp-recurrent-oral-herpes-simplex-virus-hsv-infection\/\" rel=\"tag\">Recurrent Oral Herpes Simples Virus (HSV) Infection<\/a>","rttpg_excerpt":"Prophylactic oral antiviral treatment should be considered if the patient is: Those with atypical lesions or in whom the diagnosis is uncertain (but thought to be benign) &nbsp;should be referred routinely to Oral Medicine. Patients with unexplained ulceration of the oral mucosa persisting &gt; 3 weeks should be referred as urgent, suspicious of cancer to","_links":{"self":[{"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/pages\/17726","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/comments?post=17726"}],"version-history":[{"count":3,"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/pages\/17726\/revisions"}],"predecessor-version":[{"id":30355,"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/pages\/17726\/revisions\/30355"}],"up":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/pages\/4043"}],"wp:attachment":[{"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/media?parent=17726"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/refhelp\/wp-json\/wp\/v2\/categories?post=17726"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}