{"id":1612,"date":"2025-02-27T20:31:28","date_gmt":"2025-02-27T20:31:28","guid":{"rendered":"https:\/\/apps.nhslothian.scot\/cirg\/?post_type=project&#038;p=1612"},"modified":"2025-03-03T21:07:07","modified_gmt":"2025-03-03T21:07:07","slug":"wisard","status":"publish","type":"project","link":"https:\/\/apps.nhslothian.scot\/cirg\/projects\/wisard\/","title":{"rendered":"WISARD"},"content":{"rendered":"\n<div class=\"wp-block-group alignfull fullstretch has-dark-accent-background-color has-background\" style=\"margin-top:0px;margin-bottom:0px;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-container-core-group-is-layout-fb806a89 wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-cover alignfull fullstretch cirgcover has-standard-white-color has-text-color has-link-color wp-elements-77863774b4bafa76017e3d0427e2b75c\" style=\"min-height:550px;aspect-ratio:unset;\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-dark-accent-background-color has-background-dim-100 has-background-dim\"><\/span><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"500\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/WIZARD-Logo.jpg\" class=\"wp-block-cover__image-background wp-post-image\" alt=\"WIZARD Logo\" data-object-fit=\"cover\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/WIZARD-Logo.jpg 700w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/WIZARD-Logo-300x214.jpg 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><div class=\"wp-block-cover__inner-container is-layout-constrained wp-container-core-cover-is-layout-19e250f3 wp-block-cover-is-layout-constrained\"><h1 style=\"margin-right:30px;margin-left:30px;\" class=\"has-text-align-center has-link-color alignwide wp-elements-09e237a63bfe375a0171d5feb4e4df96 wp-block-post-title has-text-color has-standard-white-color\">WISARD<\/h1>\n\n<div class=\"has-text-align-center has-link-color cirg-screen-excerpt wp-elements-657dd3814347baad505828ae04cf4996 wp-block-post-excerpt has-text-color has-standard-white-color\"><p class=\"wp-block-post-excerpt__excerpt\">An Open-label, multi-centre, randomised, switch study to evaluate the virological efficacy over 96 weeks of 2-Drug therapy with DTG\/RPV FDC in Antiretroviral treatmentexperienced HIV-1 infected subjects virologically suppressed with Nnrtis Resistance Mutation K103N <\/p><\/div><\/div><\/div>\n<\/div><\/div>\n\n\n<style>.kb-row-layout-id1612_7c09e5-98 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id1612_7c09e5-98 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id1612_7c09e5-98 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);max-width:1280px;margin-left:auto;margin-right:auto;padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, 1fr);}.kb-row-layout-id1612_7c09e5-98 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1612_7c09e5-98 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id1612_7c09e5-98 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1612_7c09e5-98 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-1-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column1612_207a81-a9 > .kt-inside-inner-col{display:flex;}.kadence-column1612_207a81-a9 > .kt-inside-inner-col{padding-top:35px;padding-right:30px;padding-bottom:40px;padding-left:30px;}.kadence-column1612_207a81-a9 > .kt-inside-inner-col,.kadence-column1612_207a81-a9 > .kt-inside-inner-col:before{border-top-left-radius:10px;border-top-right-radius:10px;border-bottom-right-radius:10px;border-bottom-left-radius:10px;}.kadence-column1612_207a81-a9 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1612_207a81-a9 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1612_207a81-a9 > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column1612_207a81-a9{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1612_207a81-a9{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1612_207a81-a9 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1612_207a81-a9 > .kt-inside-inner-col{background-color:#ffffff;}.kadence-column1612_207a81-a9 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1612_207a81-a9{position:relative;}.kadence-column1612_207a81-a9, .kt-inside-inner-col > .kadence-column1612_207a81-a9:not(.specificity){margin-top:-70px;margin-bottom:15px;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column1612_207a81-a9{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1612_207a81-a9{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1612_207a81-a9 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column1612_207a81-a9 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kt-row-column-wrap > .kadence-column1612_207a81-a9{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1612_207a81-a9{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1612_207a81-a9 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1612_207a81-a9 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1612_207a81-a9\"><div class=\"kt-inside-inner-col\"><style>.kb-row-layout-id1612_9da35d-ea > .kt-row-column-wrap{align-content:center;}:where(.kb-row-layout-id1612_9da35d-ea > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:center;}.kb-row-layout-id1612_9da35d-ea > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-lg, 3rem);grid-template-columns:repeat(2, minmax(0, 1fr));}.kb-row-layout-id1612_9da35d-ea > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1612_9da35d-ea > .kt-row-column-wrap{grid-template-columns:repeat(2, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id1612_9da35d-ea > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1612_9da35d-ea alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-middle\">\n<style>.kadence-column1612_ff1246-7d > .kt-inside-inner-col,.kadence-column1612_ff1246-7d > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1612_ff1246-7d > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1612_ff1246-7d > .kt-inside-inner-col{flex-direction:column;}.kadence-column1612_ff1246-7d > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1612_ff1246-7d > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1612_ff1246-7d{position:relative;}@media all and (max-width: 1024px){.kadence-column1612_ff1246-7d > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1612_ff1246-7d > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1612_ff1246-7d cirg-featured\"><div class=\"kt-inside-inner-col\"><figure style=\"aspect-ratio:auto;\" class=\"wp-block-post-featured-image\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"500\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/WIZARD-Logo.jpg\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image\" alt=\"WIZARD Logo\" style=\"width:100%;height:100%;object-fit:cover;\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/WIZARD-Logo.jpg 700w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/WIZARD-Logo-300x214.jpg 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/figure><\/div><\/div>\n\n\n<style>.kadence-column1612_6a3002-b9 > .kt-inside-inner-col,.kadence-column1612_6a3002-b9 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1612_6a3002-b9 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1612_6a3002-b9 > .kt-inside-inner-col{flex-direction:column;}.kadence-column1612_6a3002-b9 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1612_6a3002-b9 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1612_6a3002-b9{position:relative;}@media all and (max-width: 1024px){.kadence-column1612_6a3002-b9 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1612_6a3002-b9 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1612_6a3002-b9\"><div class=\"kt-inside-inner-col\">\n<h2 class=\"wp-block-heading alignwide project-details-heading\">Project Details<\/h2>\n\n\n\n<p>Start Date<br><strong>2019<\/strong><\/p>\n\n\n\n<p>End Date<br><strong>2021<\/strong><\/p>\n\n\n\n<p>Status<br><strong>Ongoing<\/strong><\/p>\n\n\n\n<p>Main Research Site<br><strong>RIDU<\/strong><\/p>\n<\/div><\/div>\n\n<\/div><\/div>\n\n\n<p>Main objective of the trial:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>To compare efficacy of DTG\/RPV combined tablet versus continued antiretroviral treatment regimen at 48 weeks in individuals with the K103N resistance mutation.<\/li>\n<\/ul>\n\n\n\n<p>Secondary objectives of the trial:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>To investigate whether switching patients to DTG\/RPV FDC is associated with improvement of lipid profile, patient satisfaction, quality of life and potential for drug-drug interactions, investigated over time through 96 weeks with evaluation (and comparison to control arm) at week 24, 48 and 96.<\/li>\n\n\n\n<li>To evaluate DTG &amp; RPV concentrations in blood.<\/li>\n\n\n\n<li>To evaluate changes in cell associated virus.<\/li>\n<\/ul>\n\n\n\n<p><a href=\"https:\/\/www.neat-id.org\/wisard\" target=\"_blank\" rel=\"noreferrer noopener\">Find out more about WIZARD<\/a><\/p>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-1612_cf8f1c-90 .kt-block-spacer{height:80px;}.wp-block-kadence-spacer.kt-block-spacer-1612_cf8f1c-90 .kt-divider{border-top-width:3px;height:1px;border-top-color:#F59F68;width:100%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-1612_cf8f1c-90\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><hr class=\"kt-divider\"\/><\/div><\/div>\n\n\n\n<p><strong>MAIN FUNDING BODY<\/strong><\/p>\n\n\n<style>.kb-row-layout-id1612_5b42b0-af > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id1612_5b42b0-af > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id1612_5b42b0-af > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);}.kb-row-layout-id1612_5b42b0-af > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}.kb-row-layout-id1612_5b42b0-af > .kt-row-column-wrap{grid-template-columns:repeat(3, minmax(0, 1fr));}.kb-row-layout-id1612_5b42b0-af > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1612_5b42b0-af > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}}@media all and (max-width: 1024px){.kb-row-layout-id1612_5b42b0-af > .kt-row-column-wrap{grid-template-columns:repeat(3, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id1612_5b42b0-af > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}.kb-row-layout-id1612_5b42b0-af > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1612_5b42b0-af alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-3-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column1612_966cd7-c0 > .kt-inside-inner-col,.kadence-column1612_966cd7-c0 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1612_966cd7-c0 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1612_966cd7-c0 > .kt-inside-inner-col{flex-direction:column;}.kadence-column1612_966cd7-c0 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1612_966cd7-c0 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1612_966cd7-c0{position:relative;}@media all and (max-width: 1024px){.kadence-column1612_966cd7-c0 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1612_966cd7-c0 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1612_966cd7-c0\"><div class=\"kt-inside-inner-col\"><style>.kb-image1612_86c889-3a .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image1612_86c889-3a size-full\"><a href=\"https:\/\/www.neat-id.org\/\" class=\"kb-advanced-image-link\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"500\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/neatid-Logo.jpg\" alt=\"neatid Logo\" class=\"kb-img wp-image-1613\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/neatid-Logo.jpg 700w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/neatid-Logo-300x214.jpg 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/a><\/figure>\n<\/div><\/div>\n\n\n<style>.kadence-column1612_c7fff7-e1 > .kt-inside-inner-col,.kadence-column1612_c7fff7-e1 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1612_c7fff7-e1 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1612_c7fff7-e1 > .kt-inside-inner-col{flex-direction:column;}.kadence-column1612_c7fff7-e1 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1612_c7fff7-e1 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1612_c7fff7-e1{position:relative;}@media all and (max-width: 1024px){.kadence-column1612_c7fff7-e1 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1612_c7fff7-e1 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1612_c7fff7-e1\"><div class=\"kt-inside-inner-col\"><\/div><\/div>\n\n\n<style>.kadence-column1612_f42788-68 > .kt-inside-inner-col,.kadence-column1612_f42788-68 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1612_f42788-68 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1612_f42788-68 > .kt-inside-inner-col{flex-direction:column;}.kadence-column1612_f42788-68 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1612_f42788-68 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1612_f42788-68{position:relative;}@media all and (max-width: 1024px){.kadence-column1612_f42788-68 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1612_f42788-68 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1612_f42788-68\"><div class=\"kt-inside-inner-col\"><\/div><\/div>\n\n<\/div><\/div><\/div><\/div>\n\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>An Open-label, multi-centre, randomised, switch study to evaluate the virological efficacy over 96 weeks of 2-Drug therapy with DTG\/RPV FDC in Antiretroviral treatmentexperienced HIV-1 infected subjects virologically suppressed with Nnrtis Resistance Mutation K103N<\/p>\n","protected":false},"featured_media":1614,"menu_order":0,"template":"","meta":{"_acf_changed":false,"footnotes":""},"project-type":[21],"class_list":["post-1612","project","type-project","status-publish","has-post-thumbnail","hentry","project-type-past-project"],"acf":[],"_links":{"self":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project\/1612","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/types\/project"}],"version-history":[{"count":2,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project\/1612\/revisions"}],"predecessor-version":[{"id":1830,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project\/1612\/revisions\/1830"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/media\/1614"}],"wp:attachment":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/media?parent=1612"}],"wp:term":[{"taxonomy":"project-type","embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project-type?post=1612"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}