{"id":1560,"date":"2025-02-23T22:37:14","date_gmt":"2025-02-23T22:37:14","guid":{"rendered":"https:\/\/apps.nhslothian.scot\/cirg\/?post_type=project&#038;p=1560"},"modified":"2026-03-23T17:03:52","modified_gmt":"2026-03-23T17:03:52","slug":"fluent","status":"publish","type":"project","link":"https:\/\/apps.nhslothian.scot\/cirg\/projects\/fluent\/","title":{"rendered":"Fluent"},"content":{"rendered":"\n<div class=\"wp-block-group alignfull fullstretch has-dark-accent-background-color has-background\" style=\"margin-top:0px;margin-bottom:0px;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-container-core-group-is-layout-fb806a89 wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-cover alignfull fullstretch cirgcover has-standard-white-color has-text-color has-link-color wp-elements-77863774b4bafa76017e3d0427e2b75c\" style=\"min-height:550px;aspect-ratio:unset;\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-dark-accent-background-color has-background-dim-100 has-background-dim\"><\/span><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"500\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/Fluent-Logo.jpg\" class=\"wp-block-cover__image-background wp-post-image\" alt=\"Fluent Logo\" data-object-fit=\"cover\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/Fluent-Logo.jpg 700w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/Fluent-Logo-300x214.jpg 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><div class=\"wp-block-cover__inner-container is-layout-constrained wp-container-core-cover-is-layout-19e250f3 wp-block-cover-is-layout-constrained\"><h1 style=\"margin-right:30px;margin-left:30px;\" class=\"has-text-align-center has-link-color alignwide wp-elements-09e237a63bfe375a0171d5feb4e4df96 wp-block-post-title has-text-color has-standard-white-color\">Fluent<\/h1>\n\n<div class=\"has-text-align-center has-link-color cirg-screen-excerpt wp-elements-657dd3814347baad505828ae04cf4996 wp-block-post-excerpt has-text-color has-standard-white-color\"><p class=\"wp-block-post-excerpt__excerpt\">A Phase 3, Randomized, Observer-blind, Active-controlled Study to Investigate the Safety, Reactogenicity, and Efficacy of mRNA-1010 Candidate Seasonal Influenza Vaccine Compared with a Licensed Inactivated Seasonal Influenza Vaccine in Adults &ge;50 Years of Age <\/p><\/div><\/div><\/div>\n<\/div><\/div>\n\n\n<style>.kb-row-layout-id1560_f563c1-27 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id1560_f563c1-27 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id1560_f563c1-27 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);max-width:1280px;margin-left:auto;margin-right:auto;padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, 1fr);}.kb-row-layout-id1560_f563c1-27 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1560_f563c1-27 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id1560_f563c1-27 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1560_f563c1-27 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-1-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column1560_d4f924-9f > .kt-inside-inner-col{display:flex;}.kadence-column1560_d4f924-9f > .kt-inside-inner-col{padding-top:35px;padding-right:30px;padding-bottom:40px;padding-left:30px;}.kadence-column1560_d4f924-9f > .kt-inside-inner-col,.kadence-column1560_d4f924-9f > .kt-inside-inner-col:before{border-top-left-radius:10px;border-top-right-radius:10px;border-bottom-right-radius:10px;border-bottom-left-radius:10px;}.kadence-column1560_d4f924-9f > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1560_d4f924-9f > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1560_d4f924-9f > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column1560_d4f924-9f{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1560_d4f924-9f{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1560_d4f924-9f > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1560_d4f924-9f > .kt-inside-inner-col{background-color:#ffffff;}.kadence-column1560_d4f924-9f > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1560_d4f924-9f{position:relative;}.kadence-column1560_d4f924-9f, .kt-inside-inner-col > .kadence-column1560_d4f924-9f:not(.specificity){margin-top:-70px;margin-bottom:15px;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column1560_d4f924-9f{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1560_d4f924-9f{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1560_d4f924-9f > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column1560_d4f924-9f > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kt-row-column-wrap > .kadence-column1560_d4f924-9f{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1560_d4f924-9f{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1560_d4f924-9f > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1560_d4f924-9f > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1560_d4f924-9f\"><div class=\"kt-inside-inner-col\"><style>.kb-row-layout-id1560_d5bac2-5b > .kt-row-column-wrap{align-content:center;}:where(.kb-row-layout-id1560_d5bac2-5b > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:center;}.kb-row-layout-id1560_d5bac2-5b > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-lg, 3rem);grid-template-columns:repeat(2, minmax(0, 1fr));}.kb-row-layout-id1560_d5bac2-5b > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1560_d5bac2-5b > .kt-row-column-wrap{grid-template-columns:repeat(2, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id1560_d5bac2-5b > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1560_d5bac2-5b alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-middle\">\n<style>.kadence-column1560_54a215-39 > .kt-inside-inner-col,.kadence-column1560_54a215-39 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1560_54a215-39 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1560_54a215-39 > .kt-inside-inner-col{flex-direction:column;}.kadence-column1560_54a215-39 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1560_54a215-39 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1560_54a215-39{position:relative;}@media all and (max-width: 1024px){.kadence-column1560_54a215-39 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1560_54a215-39 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1560_54a215-39 cirg-featured\"><div class=\"kt-inside-inner-col\"><figure style=\"aspect-ratio:auto;\" class=\"wp-block-post-featured-image\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"500\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/Fluent-Logo.jpg\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image\" alt=\"Fluent Logo\" style=\"width:100%;height:100%;object-fit:cover;\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/Fluent-Logo.jpg 700w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/Fluent-Logo-300x214.jpg 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/figure><\/div><\/div>\n\n\n<style>.kadence-column1560_9fc18e-2c > .kt-inside-inner-col,.kadence-column1560_9fc18e-2c > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1560_9fc18e-2c > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1560_9fc18e-2c > .kt-inside-inner-col{flex-direction:column;}.kadence-column1560_9fc18e-2c > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1560_9fc18e-2c > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1560_9fc18e-2c{position:relative;}@media all and (max-width: 1024px){.kadence-column1560_9fc18e-2c > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1560_9fc18e-2c > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1560_9fc18e-2c\"><div class=\"kt-inside-inner-col\">\n<h2 class=\"wp-block-heading alignwide project-details-heading\">Project Details<\/h2>\n\n\n\n<p>Start Date<br><strong>October 2024<\/strong><\/p>\n\n\n\n<p>Principal Investigator<br><a href=\"\/cirg\/people\/dr-rebecca-k-sutherland\/\">Dr Rebecca K Sutherland<\/a><\/p>\n<\/div><\/div>\n\n<\/div><\/div>\n\n\n<p>Influenza (Flu) is a seasonal respiratory illness, which affects the lungs and airways and is easily spread from person to person. It tends to flare up during the winter months each year and can be responsible for thousands of people visiting the hospital every day in the UK. It&nbsp;is estimated to cause 3 to 5 million cases of severe illness and up to 650,000 deaths each year worldwide.<\/p>\n\n\n\n<p>The Fluent trial is being run, by Moderna,&nbsp; to establish if their investigational seasonal flu vaccine may be able to prevent seasonal flu for people 50 years of age or older. The trial vaccine will be compared with the seasonal flu vaccine which is already approved for use and is the current standard practice to evaluate the safety and immune response. The investigational vaccine is an m-RNA based vaccine. This type of vaccine aim to teach the body how to make a specific protein that may potentially help the immune system prevent or treat certain diseases. The hope is that the vaccine trains the immune system cells to \u201cremember\u201d these proteins and helps your body quickly protect against the strain of infection if exposed in the future.<\/p>\n\n\n\n<p>This trial is a Phase 3, randomised, double-blind, active-control, evidence-driven clinical trial. This means the investigational vaccine has been through several stages of trials already and so the purpose of this trial is to evaluate the efficacy and safety for use in a large group of people as it is the last phase of testing before it can be made available for public use. It is a randomised double-blinded trial, it means the participant will receive either the investigational drug or the standard approved drug but neither they or the research nurses will know which one.<\/p>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-1560_356c54-51 .kt-block-spacer{height:80px;}.wp-block-kadence-spacer.kt-block-spacer-1560_356c54-51 .kt-divider{border-top-width:3px;height:1px;border-top-color:#F59F68;width:100%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-1560_356c54-51\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><hr class=\"kt-divider\" \/><\/div><\/div>\n\n\n\n<p><strong>MAIN FUNDING BODY<\/strong><\/p>\n\n\n<style>.kb-row-layout-id1560_a69c80-d4 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id1560_a69c80-d4 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id1560_a69c80-d4 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);}.kb-row-layout-id1560_a69c80-d4 > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}.kb-row-layout-id1560_a69c80-d4 > .kt-row-column-wrap{grid-template-columns:repeat(3, minmax(0, 1fr));}.kb-row-layout-id1560_a69c80-d4 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1560_a69c80-d4 > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}}@media all and (max-width: 1024px){.kb-row-layout-id1560_a69c80-d4 > .kt-row-column-wrap{grid-template-columns:repeat(3, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id1560_a69c80-d4 > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}.kb-row-layout-id1560_a69c80-d4 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1560_a69c80-d4 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-3-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column1560_468b64-2c > .kt-inside-inner-col,.kadence-column1560_468b64-2c > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1560_468b64-2c > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1560_468b64-2c > .kt-inside-inner-col{flex-direction:column;}.kadence-column1560_468b64-2c > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1560_468b64-2c > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1560_468b64-2c{position:relative;}@media all and (max-width: 1024px){.kadence-column1560_468b64-2c > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1560_468b64-2c > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1560_468b64-2c\"><div class=\"kt-inside-inner-col\"><style>.kb-image1560_97c6aa-ae .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image1560_97c6aa-ae size-full\"><a href=\"https:\/\/www.modernatx.com\/en-GB\" class=\"kb-advanced-image-link\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"500\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/moderna-logo.jpg\" alt=\"moderna logo\" class=\"kb-img wp-image-1524\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/moderna-logo.jpg 700w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/moderna-logo-300x214.jpg 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/a><\/figure>\n<\/div><\/div>\n\n\n<style>.kadence-column1560_1af2c5-3d > .kt-inside-inner-col,.kadence-column1560_1af2c5-3d > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1560_1af2c5-3d > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1560_1af2c5-3d > .kt-inside-inner-col{flex-direction:column;}.kadence-column1560_1af2c5-3d > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1560_1af2c5-3d > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1560_1af2c5-3d{position:relative;}@media all and (max-width: 1024px){.kadence-column1560_1af2c5-3d > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1560_1af2c5-3d > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1560_1af2c5-3d\"><div class=\"kt-inside-inner-col\"><\/div><\/div>\n\n\n<style>.kadence-column1560_514846-d8 > .kt-inside-inner-col,.kadence-column1560_514846-d8 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1560_514846-d8 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1560_514846-d8 > .kt-inside-inner-col{flex-direction:column;}.kadence-column1560_514846-d8 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1560_514846-d8 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1560_514846-d8{position:relative;}@media all and (max-width: 1024px){.kadence-column1560_514846-d8 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1560_514846-d8 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1560_514846-d8\"><div class=\"kt-inside-inner-col\"><\/div><\/div>\n\n<\/div><\/div>\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-icon__arrow-right\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/cirg\/projects\">See All Projects<span class=\"wp-block-button__link-icon\" aria-hidden=\"true\"><svg viewBox='0 0 16 11' xmlns='http:\/\/www.w3.org\/2000\/svg'><polygon points='0 4.7 13.1180124 4.7 9.44099379 1 10.4347826 0 16 5.5 10.4347826 11 9.44099379 10 13.1180124 6.3 0 6.3'><\/polygon><\/svg><\/span><\/a><\/div>\n<\/div>\n<\/div><\/div>\n\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>A Phase 3, Randomized, Observer-blind, Active-controlled Study to Investigate the Safety, Reactogenicity, and Efficacy of mRNA-1010 Candidate Seasonal Influenza Vaccine Compared with a Licensed Inactivated Seasonal Influenza Vaccine in Adults \u226550 Years of Age<\/p>\n","protected":false},"featured_media":1561,"menu_order":0,"template":"","meta":{"_acf_changed":false,"footnotes":""},"project-type":[19,21],"class_list":["post-1560","project","type-project","status-publish","has-post-thumbnail","hentry","project-type-clinical-trials","project-type-past-project"],"acf":[],"_links":{"self":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project\/1560","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/types\/project"}],"version-history":[{"count":3,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project\/1560\/revisions"}],"predecessor-version":[{"id":2092,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project\/1560\/revisions\/2092"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/media\/1561"}],"wp:attachment":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/media?parent=1560"}],"wp:term":[{"taxonomy":"project-type","embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project-type?post=1560"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}