{"id":1557,"date":"2025-02-23T22:28:10","date_gmt":"2025-02-23T22:28:10","guid":{"rendered":"https:\/\/apps.nhslothian.scot\/cirg\/?post_type=project&#038;p=1557"},"modified":"2025-03-03T20:05:49","modified_gmt":"2025-03-03T20:05:49","slug":"nova-301","status":"publish","type":"project","link":"https:\/\/apps.nhslothian.scot\/cirg\/projects\/nova-301\/","title":{"rendered":"Nova 301"},"content":{"rendered":"\n<div class=\"wp-block-group alignfull fullstretch has-dark-accent-background-color has-background\" style=\"margin-top:0px;margin-bottom:0px;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-container-core-group-is-layout-fb806a89 wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-cover alignfull fullstretch cirgcover has-standard-white-color has-text-color has-link-color wp-elements-77863774b4bafa76017e3d0427e2b75c\" style=\"min-height:550px;aspect-ratio:unset;\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-dark-accent-background-color has-background-dim-100 has-background-dim\"><\/span><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"500\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/NOVA-301-Trial-Logo.jpg\" class=\"wp-block-cover__image-background wp-post-image\" alt=\"NOVA 301 Trial Logo\" data-object-fit=\"cover\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/NOVA-301-Trial-Logo.jpg 700w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/NOVA-301-Trial-Logo-300x214.jpg 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><div class=\"wp-block-cover__inner-container is-layout-constrained wp-container-core-cover-is-layout-19e250f3 wp-block-cover-is-layout-constrained\"><h1 style=\"margin-right:30px;margin-left:30px;\" class=\"has-text-align-center has-link-color alignwide wp-elements-09e237a63bfe375a0171d5feb4e4df96 wp-block-post-title has-text-color has-standard-white-color\">Nova 301<\/h1>\n\n<div class=\"has-text-align-center has-link-color cirg-screen-excerpt wp-elements-657dd3814347baad505828ae04cf4996 wp-block-post-excerpt has-text-color has-standard-white-color\"><p class=\"wp-block-post-excerpt__excerpt\">A Phase 3, Randomized, Observer-blinded, Placebo-Controlled Study to Evaluate the Safety and Efficacy of mRNA-1403, a Multivalent Candidate Vaccine to Prevent Norovirus Acute Gastroenteritis in Adults &ge;18 Years of Age <\/p><\/div><\/div><\/div>\n<\/div><\/div>\n\n\n<style>.kb-row-layout-id1557_0d23db-2f > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id1557_0d23db-2f > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id1557_0d23db-2f > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);max-width:1280px;margin-left:auto;margin-right:auto;padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, 1fr);}.kb-row-layout-id1557_0d23db-2f > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1557_0d23db-2f > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id1557_0d23db-2f > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1557_0d23db-2f alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-1-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column1557_22fc0f-98 > .kt-inside-inner-col{display:flex;}.kadence-column1557_22fc0f-98 > .kt-inside-inner-col{padding-top:35px;padding-right:30px;padding-bottom:40px;padding-left:30px;}.kadence-column1557_22fc0f-98 > .kt-inside-inner-col,.kadence-column1557_22fc0f-98 > .kt-inside-inner-col:before{border-top-left-radius:10px;border-top-right-radius:10px;border-bottom-right-radius:10px;border-bottom-left-radius:10px;}.kadence-column1557_22fc0f-98 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1557_22fc0f-98 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1557_22fc0f-98 > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column1557_22fc0f-98{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1557_22fc0f-98{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1557_22fc0f-98 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1557_22fc0f-98 > .kt-inside-inner-col{background-color:#ffffff;}.kadence-column1557_22fc0f-98 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1557_22fc0f-98{position:relative;}.kadence-column1557_22fc0f-98, .kt-inside-inner-col > .kadence-column1557_22fc0f-98:not(.specificity){margin-top:-70px;margin-bottom:15px;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column1557_22fc0f-98{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1557_22fc0f-98{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1557_22fc0f-98 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column1557_22fc0f-98 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kt-row-column-wrap > .kadence-column1557_22fc0f-98{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1557_22fc0f-98{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1557_22fc0f-98 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1557_22fc0f-98 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1557_22fc0f-98\"><div class=\"kt-inside-inner-col\"><style>.kb-row-layout-id1557_0d7c56-0a > .kt-row-column-wrap{align-content:center;}:where(.kb-row-layout-id1557_0d7c56-0a > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:center;}.kb-row-layout-id1557_0d7c56-0a > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-lg, 3rem);grid-template-columns:repeat(2, minmax(0, 1fr));}.kb-row-layout-id1557_0d7c56-0a > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1557_0d7c56-0a > .kt-row-column-wrap{grid-template-columns:repeat(2, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id1557_0d7c56-0a > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1557_0d7c56-0a alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-middle\">\n<style>.kadence-column1557_445bae-83 > .kt-inside-inner-col,.kadence-column1557_445bae-83 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1557_445bae-83 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1557_445bae-83 > .kt-inside-inner-col{flex-direction:column;}.kadence-column1557_445bae-83 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1557_445bae-83 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1557_445bae-83{position:relative;}@media all and (max-width: 1024px){.kadence-column1557_445bae-83 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1557_445bae-83 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1557_445bae-83 cirg-featured\"><div class=\"kt-inside-inner-col\"><figure style=\"aspect-ratio:auto;\" class=\"wp-block-post-featured-image\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"500\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/NOVA-301-Trial-Logo.jpg\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image\" alt=\"NOVA 301 Trial Logo\" style=\"width:100%;height:100%;object-fit:cover;\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/NOVA-301-Trial-Logo.jpg 700w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/NOVA-301-Trial-Logo-300x214.jpg 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/figure><\/div><\/div>\n\n\n<style>.kadence-column1557_e0110a-e5 > .kt-inside-inner-col,.kadence-column1557_e0110a-e5 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1557_e0110a-e5 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1557_e0110a-e5 > .kt-inside-inner-col{flex-direction:column;}.kadence-column1557_e0110a-e5 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1557_e0110a-e5 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1557_e0110a-e5{position:relative;}@media all and (max-width: 1024px){.kadence-column1557_e0110a-e5 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1557_e0110a-e5 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1557_e0110a-e5\"><div class=\"kt-inside-inner-col\">\n<h2 class=\"wp-block-heading alignwide project-details-heading\">Project Details<\/h2>\n\n\n\n<p>Start Date<br><strong>November 2025<\/strong><\/p>\n\n\n\n<p>Principal Investigator<br><a href=\"\/cirg\/people\/dr-oliver-koch\/\">Dr Oliver Koch<\/a><\/p>\n<\/div><\/div>\n\n<\/div><\/div>\n\n\n<p>Norovirus, commonly known as the winter sickness bug, is one of the most common stomach bugs in the UK. It can spread easily and most cases are often in care homes and schools. The Norovirus stomach bug can cause many unpleasant symptoms like nausea, vomiting, and diarrhoea. Vulnerable people, such as adults older than age 60, and people with underlying health conditions, are at greater risk for serious symptoms of norovirus, which may require medical attention.<\/p>\n\n\n\n<p>The Nova 301 Trial is a Phase 3 clinical trial, run by Moderna, looking at the efficacy of their vaccine to protect people against the symptoms of Norovirus. As it is a phase 3 trial, it is in the final stages of the trial process before the investigational vaccine can be made available for public use (after approval from the UK Medicines and Healthcare products Regulatory Agency). Phase 3 trials like this one evaluate the investigational vaccine in a large group of people.<\/p>\n\n\n\n<p>As there isn\u2019t a current Norovirus vaccine available for comparison, the vaccine will be trialled against a placebo, to allow the researchers&nbsp; to compare the benefits between havening the vaccine or not. The trial is a double blinded trial meaning neither the participant or the nursing team will know which one the participants receive.<\/p>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-1557_424018-29 .kt-block-spacer{height:80px;}.wp-block-kadence-spacer.kt-block-spacer-1557_424018-29 .kt-divider{border-top-width:3px;height:1px;border-top-color:#F59F68;width:100%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-1557_424018-29\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><hr class=\"kt-divider\"\/><\/div><\/div>\n\n\n\n<p><strong>MAIN FUNDING BODY<\/strong><\/p>\n\n\n<style>.kb-row-layout-id1557_e85626-23 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id1557_e85626-23 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id1557_e85626-23 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);}.kb-row-layout-id1557_e85626-23 > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}.kb-row-layout-id1557_e85626-23 > .kt-row-column-wrap{grid-template-columns:repeat(3, minmax(0, 1fr));}.kb-row-layout-id1557_e85626-23 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1557_e85626-23 > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}}@media all and (max-width: 1024px){.kb-row-layout-id1557_e85626-23 > .kt-row-column-wrap{grid-template-columns:repeat(3, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id1557_e85626-23 > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}.kb-row-layout-id1557_e85626-23 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1557_e85626-23 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-3-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column1557_e537d3-29 > .kt-inside-inner-col,.kadence-column1557_e537d3-29 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1557_e537d3-29 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1557_e537d3-29 > .kt-inside-inner-col{flex-direction:column;}.kadence-column1557_e537d3-29 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1557_e537d3-29 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1557_e537d3-29{position:relative;}@media all and (max-width: 1024px){.kadence-column1557_e537d3-29 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1557_e537d3-29 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1557_e537d3-29\"><div class=\"kt-inside-inner-col\"><style>.kb-image1557_cef114-a5 .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image1557_cef114-a5 size-full\"><a href=\"https:\/\/www.modernatx.com\/en-GB\" class=\"kb-advanced-image-link\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"500\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/moderna-logo.jpg\" alt=\"moderna logo\" class=\"kb-img wp-image-1524\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/moderna-logo.jpg 700w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/moderna-logo-300x214.jpg 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/a><\/figure>\n<\/div><\/div>\n\n\n<style>.kadence-column1557_2bc237-fa > .kt-inside-inner-col,.kadence-column1557_2bc237-fa > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1557_2bc237-fa > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1557_2bc237-fa > .kt-inside-inner-col{flex-direction:column;}.kadence-column1557_2bc237-fa > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1557_2bc237-fa > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1557_2bc237-fa{position:relative;}@media all and (max-width: 1024px){.kadence-column1557_2bc237-fa > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1557_2bc237-fa > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1557_2bc237-fa\"><div class=\"kt-inside-inner-col\"><\/div><\/div>\n\n\n<style>.kadence-column1557_cf91bc-60 > .kt-inside-inner-col,.kadence-column1557_cf91bc-60 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1557_cf91bc-60 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1557_cf91bc-60 > .kt-inside-inner-col{flex-direction:column;}.kadence-column1557_cf91bc-60 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1557_cf91bc-60 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1557_cf91bc-60{position:relative;}@media all and (max-width: 1024px){.kadence-column1557_cf91bc-60 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1557_cf91bc-60 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1557_cf91bc-60\"><div class=\"kt-inside-inner-col\"><\/div><\/div>\n\n<\/div><\/div>\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-icon__arrow-right\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/cirg\/projects\">See All Projects<span class=\"wp-block-button__link-icon\" aria-hidden=\"true\"><svg viewBox='0 0 16 11' xmlns='http:\/\/www.w3.org\/2000\/svg'><polygon points='0 4.7 13.1180124 4.7 9.44099379 1 10.4347826 0 16 5.5 10.4347826 11 9.44099379 10 13.1180124 6.3 0 6.3'><\/polygon><\/svg><\/span><\/a><\/div>\n<\/div>\n<\/div><\/div>\n\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>A Phase 3, Randomized, Observer-blinded, Placebo-Controlled Study to Evaluate the Safety and Efficacy of mRNA-1403, a Multivalent Candidate Vaccine to Prevent Norovirus Acute Gastroenteritis in Adults \u226518 Years of Age<\/p>\n","protected":false},"featured_media":1558,"menu_order":0,"template":"","meta":{"_acf_changed":false,"footnotes":""},"project-type":[19,22],"class_list":["post-1557","project","type-project","status-publish","has-post-thumbnail","hentry","project-type-clinical-trials","project-type-current-project"],"acf":[],"_links":{"self":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project\/1557","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/types\/project"}],"version-history":[{"count":2,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project\/1557\/revisions"}],"predecessor-version":[{"id":1799,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project\/1557\/revisions\/1799"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/media\/1558"}],"wp:attachment":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/media?parent=1557"}],"wp:term":[{"taxonomy":"project-type","embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project-type?post=1557"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}