{"id":1512,"date":"2025-02-23T16:40:03","date_gmt":"2025-02-23T16:40:03","guid":{"rendered":"https:\/\/apps.nhslothian.scot\/cirg\/?post_type=project&#038;p=1512"},"modified":"2025-03-03T20:31:21","modified_gmt":"2025-03-03T20:31:21","slug":"rio","status":"publish","type":"project","link":"https:\/\/apps.nhslothian.scot\/cirg\/projects\/rio\/","title":{"rendered":"RIO"},"content":{"rendered":"\n<div class=\"wp-block-group alignfull fullstretch has-dark-accent-background-color has-background\" style=\"margin-top:0px;margin-bottom:0px;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-container-core-group-is-layout-fb806a89 wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-cover alignfull fullstretch cirgcover has-standard-white-color has-text-color has-link-color wp-elements-77863774b4bafa76017e3d0427e2b75c\" style=\"min-height:550px;aspect-ratio:unset;\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-dark-accent-background-color has-background-dim-100 has-background-dim\"><\/span><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"500\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/RIO-Logo.jpg\" class=\"wp-block-cover__image-background wp-post-image\" alt=\"RIO Logo\" data-object-fit=\"cover\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/RIO-Logo.jpg 700w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/RIO-Logo-300x214.jpg 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><div class=\"wp-block-cover__inner-container is-layout-constrained wp-container-core-cover-is-layout-19e250f3 wp-block-cover-is-layout-constrained\"><h1 style=\"margin-right:30px;margin-left:30px;\" class=\"has-text-align-center has-link-color alignwide wp-elements-09e237a63bfe375a0171d5feb4e4df96 wp-block-post-title has-text-color has-standard-white-color\">RIO<\/h1>\n\n<div class=\"has-text-align-center has-link-color cirg-screen-excerpt wp-elements-657dd3814347baad505828ae04cf4996 wp-block-post-excerpt has-text-color has-standard-white-color\"><p class=\"wp-block-post-excerpt__excerpt\">A randomised placebo controlled trial of ART plus dual long-acting HIV-specific broadly neutralising antibodies (bNAbs) vs ART plus placebo in treated Primary HIV Infection on viral control off ART <\/p><\/div><\/div><\/div>\n<\/div><\/div>\n\n\n<style>.kb-row-layout-id1512_e40bd7-ce > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id1512_e40bd7-ce > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id1512_e40bd7-ce > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);max-width:1280px;margin-left:auto;margin-right:auto;padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, 1fr);}.kb-row-layout-id1512_e40bd7-ce > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1512_e40bd7-ce > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id1512_e40bd7-ce > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1512_e40bd7-ce alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-1-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column1512_35e7ef-a2 > .kt-inside-inner-col{display:flex;}.kadence-column1512_35e7ef-a2 > .kt-inside-inner-col{padding-top:35px;padding-right:30px;padding-bottom:40px;padding-left:30px;}.kadence-column1512_35e7ef-a2 > .kt-inside-inner-col,.kadence-column1512_35e7ef-a2 > .kt-inside-inner-col:before{border-top-left-radius:10px;border-top-right-radius:10px;border-bottom-right-radius:10px;border-bottom-left-radius:10px;}.kadence-column1512_35e7ef-a2 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1512_35e7ef-a2 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1512_35e7ef-a2 > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column1512_35e7ef-a2{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1512_35e7ef-a2{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1512_35e7ef-a2 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1512_35e7ef-a2 > .kt-inside-inner-col{background-color:#ffffff;}.kadence-column1512_35e7ef-a2 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1512_35e7ef-a2{position:relative;}.kadence-column1512_35e7ef-a2, .kt-inside-inner-col > .kadence-column1512_35e7ef-a2:not(.specificity){margin-top:-70px;margin-bottom:15px;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column1512_35e7ef-a2{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1512_35e7ef-a2{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1512_35e7ef-a2 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column1512_35e7ef-a2 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kt-row-column-wrap > .kadence-column1512_35e7ef-a2{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1512_35e7ef-a2{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1512_35e7ef-a2 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1512_35e7ef-a2 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1512_35e7ef-a2\"><div class=\"kt-inside-inner-col\"><style>.kb-row-layout-id1512_0596bc-b7 > .kt-row-column-wrap{align-content:center;}:where(.kb-row-layout-id1512_0596bc-b7 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:center;}.kb-row-layout-id1512_0596bc-b7 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-lg, 3rem);grid-template-columns:repeat(2, minmax(0, 1fr));}.kb-row-layout-id1512_0596bc-b7 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1512_0596bc-b7 > .kt-row-column-wrap{grid-template-columns:repeat(2, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id1512_0596bc-b7 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1512_0596bc-b7 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-middle\">\n<style>.kadence-column1512_2aede0-35 > .kt-inside-inner-col,.kadence-column1512_2aede0-35 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1512_2aede0-35 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1512_2aede0-35 > .kt-inside-inner-col{flex-direction:column;}.kadence-column1512_2aede0-35 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1512_2aede0-35 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1512_2aede0-35{position:relative;}@media all and (max-width: 1024px){.kadence-column1512_2aede0-35 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1512_2aede0-35 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1512_2aede0-35 cirg-featured\"><div class=\"kt-inside-inner-col\"><figure style=\"aspect-ratio:auto;\" class=\"wp-block-post-featured-image\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"500\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/RIO-Logo.jpg\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image\" alt=\"RIO Logo\" style=\"width:100%;height:100%;object-fit:cover;\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/RIO-Logo.jpg 700w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/RIO-Logo-300x214.jpg 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/figure><\/div><\/div>\n\n\n<style>.kadence-column1512_30624e-06 > .kt-inside-inner-col,.kadence-column1512_30624e-06 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1512_30624e-06 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1512_30624e-06 > .kt-inside-inner-col{flex-direction:column;}.kadence-column1512_30624e-06 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1512_30624e-06 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1512_30624e-06{position:relative;}@media all and (max-width: 1024px){.kadence-column1512_30624e-06 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1512_30624e-06 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1512_30624e-06\"><div class=\"kt-inside-inner-col\">\n<h2 class=\"wp-block-heading alignwide project-details-heading\">Project Details<\/h2>\n\n\n\n<p>Start Date<br><strong>August 2022<\/strong><\/p>\n\n\n\n<p>Status<br><strong>Closed to Recruitment<\/strong><\/p>\n\n\n\n<p>Principal Investigator<br><a href=\"\/cirg\/people\/dr-rebecca-k-sutherland\/\">Dr Rebecca K Sutherland<\/a><\/p>\n<\/div><\/div>\n\n<\/div><\/div>\n\n\n<p>Although the majority of people living with HIV make an antibody response to the virus, these are frequently ineffective and fail to neutralise the virus (i.e. are \u2018non-neutralising\u2019), partly due to the development of immune escape mutations in the HIV&nbsp;<em>env&nbsp;<\/em>gene. High titres of broadly neutralising antibodies (bNAbs) \u2013 some of which can neutralise up to 90% of circulating strains \u2013 are only made by a small percentage of people and take several years to develop. Until recently bNAbs could not be produced&nbsp;<em>ex vivo&nbsp;<\/em>to adequate levels using standard immunisation strategies. However, the rise of single cell cloning techniques has revolutionised the field and high titres of bNAbs can now be produced. Further advances have come with the development of LS strains that have much longer half-lives and the potential to further extend the period of virological suppression in the absence of ART.<\/p>\n\n\n\n<p>Over the last few years, bNAbs have entered the clinical arena, initially through proof of concept studies in animal models, followed by dosing and safety studies in humans and then efficacy studies.<\/p>\n\n\n\n<p>The RIO study aims to enrol 72 individuals across multiple UK collaborating clinical centres, and is designed to test the hypothesis that for individuals who commenced antiretroviral therapy (ART) in primary HIV infection (PHI), a combination of the two long-acting broadly neutralising antibodies, 3BNC117-LS and 10-1074-LS, will induce a period of virological remission when ART is stopped compared with participants who received ART plus placebo.<\/p>\n\n\n\n<p>The combination of 3BNC117 and 10-1074 has been tested in humans in a single-arm proof of principle study that suggested that this combination can impose full, sustained viral suppression in the absence of ART. This finding now needs to be investigated using dual long-acting versions of the antibodies in a randomised clinical trial powered to answer the question of whether these bNAbs are effective at controlling HIV replication in the absence of ART.<\/p>\n\n\n\n<p>The results from this trial will demonstrate whether or not the combination of two long-acting (LS) broadly neutralising antibodies, 3BNC117-LS and 10-1074-LS, will prevent HIV viral rebound after stopping antiretroviral therapy for an extended period of time.<\/p>\n\n\n\n<p>The trial \u2013 with samples taken during the different permutations of the intervention \u2013 will also allow insights into and detailed analysis of adaptive and innate immune responses and the virological correlates of HIV remission off antiretroviral therapy.<\/p>\n\n\n\n<p><strong>Summary of the RIO Study design:<\/strong><\/p>\n\n\n<style>.kb-image1512_34890e-64 .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<div class=\"wp-block-kadence-image kb-image1512_34890e-64\"><figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"977\" height=\"384\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/RIO-Study-design-diagram.png\" alt=\"RIO Study design diagram\" class=\"kb-img wp-image-1511\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/RIO-Study-design-diagram.png 977w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/RIO-Study-design-diagram-300x118.png 300w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/RIO-Study-design-diagram-768x302.png 768w\" sizes=\"auto, (max-width: 977px) 100vw, 977px\" \/><\/figure><\/div>\n\n\n\n<p><a href=\"https:\/\/riotrial.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">You can read more about the RIO study on the&nbsp;trial website<\/a><\/p>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-1512_36089f-53 .kt-block-spacer{height:80px;}.wp-block-kadence-spacer.kt-block-spacer-1512_36089f-53 .kt-divider{border-top-width:3px;height:1px;border-top-color:#F59F68;width:100%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-1512_36089f-53\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><hr class=\"kt-divider\"\/><\/div><\/div>\n\n\n\n<p><strong>MAIN FUNDING BODY<\/strong><\/p>\n\n\n<style>.kb-row-layout-id1512_ff25ed-b2 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id1512_ff25ed-b2 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id1512_ff25ed-b2 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);}.kb-row-layout-id1512_ff25ed-b2 > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}.kb-row-layout-id1512_ff25ed-b2 > .kt-row-column-wrap{grid-template-columns:repeat(3, minmax(0, 1fr));}.kb-row-layout-id1512_ff25ed-b2 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1512_ff25ed-b2 > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}}@media all and (max-width: 1024px){.kb-row-layout-id1512_ff25ed-b2 > .kt-row-column-wrap{grid-template-columns:repeat(3, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id1512_ff25ed-b2 > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}.kb-row-layout-id1512_ff25ed-b2 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1512_ff25ed-b2 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-3-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column1512_d5374e-12 > .kt-inside-inner-col,.kadence-column1512_d5374e-12 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1512_d5374e-12 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1512_d5374e-12 > .kt-inside-inner-col{flex-direction:column;}.kadence-column1512_d5374e-12 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1512_d5374e-12 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1512_d5374e-12{position:relative;}@media all and (max-width: 1024px){.kadence-column1512_d5374e-12 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1512_d5374e-12 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1512_d5374e-12\"><div class=\"kt-inside-inner-col\"><style>.kb-image1512_cba1d3-0b .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image1512_cba1d3-0b size-full\"><a href=\"https:\/\/www.imperial.ac.uk\/\" class=\"kb-advanced-image-link\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"500\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/Imperial-College-London-logo.jpg\" alt=\"Imperial College London logo\" class=\"kb-img wp-image-1509\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/Imperial-College-London-logo.jpg 700w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/Imperial-College-London-logo-300x214.jpg 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/a><\/figure>\n<\/div><\/div>\n\n\n<style>.kadence-column1512_e22c78-6a > .kt-inside-inner-col,.kadence-column1512_e22c78-6a > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1512_e22c78-6a > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1512_e22c78-6a > .kt-inside-inner-col{flex-direction:column;}.kadence-column1512_e22c78-6a > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1512_e22c78-6a > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1512_e22c78-6a{position:relative;}@media all and (max-width: 1024px){.kadence-column1512_e22c78-6a > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1512_e22c78-6a > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1512_e22c78-6a\"><div class=\"kt-inside-inner-col\"><style>.kb-image1512_a6371c-23 .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image1512_a6371c-23 size-full\"><a href=\"https:\/\/www.gatesfoundation.org\/\" class=\"kb-advanced-image-link\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"500\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/Bill-and-Melinda-Gates-Foundation-logo.jpg\" alt=\"Bill and Melinda Gates Foundation logo\" class=\"kb-img wp-image-1508\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/Bill-and-Melinda-Gates-Foundation-logo.jpg 700w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/Bill-and-Melinda-Gates-Foundation-logo-300x214.jpg 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/a><\/figure>\n<\/div><\/div>\n\n\n<style>.kadence-column1512_109618-f4 > .kt-inside-inner-col,.kadence-column1512_109618-f4 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1512_109618-f4 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1512_109618-f4 > .kt-inside-inner-col{flex-direction:column;}.kadence-column1512_109618-f4 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1512_109618-f4 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1512_109618-f4{position:relative;}@media all and (max-width: 1024px){.kadence-column1512_109618-f4 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1512_109618-f4 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1512_109618-f4\"><div class=\"kt-inside-inner-col\"><\/div><\/div>\n\n<\/div><\/div>\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-icon__arrow-right\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/cirg\/projects\">See All Projects<span class=\"wp-block-button__link-icon\" aria-hidden=\"true\"><svg viewBox='0 0 16 11' xmlns='http:\/\/www.w3.org\/2000\/svg'><polygon points='0 4.7 13.1180124 4.7 9.44099379 1 10.4347826 0 16 5.5 10.4347826 11 9.44099379 10 13.1180124 6.3 0 6.3'><\/polygon><\/svg><\/span><\/a><\/div>\n<\/div>\n<\/div><\/div>\n\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>A randomised placebo controlled trial of ART plus dual long-acting HIV-specific broadly neutralising antibodies (bNAbs) vs ART plus placebo in treated Primary HIV Infection on viral control off ART<\/p>\n","protected":false},"featured_media":1510,"menu_order":0,"template":"","meta":{"_acf_changed":false,"footnotes":""},"project-type":[19,22],"class_list":["post-1512","project","type-project","status-publish","has-post-thumbnail","hentry","project-type-clinical-trials","project-type-current-project"],"acf":[],"_links":{"self":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project\/1512","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/types\/project"}],"version-history":[{"count":2,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project\/1512\/revisions"}],"predecessor-version":[{"id":1813,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project\/1512\/revisions\/1813"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/media\/1510"}],"wp:attachment":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/media?parent=1512"}],"wp:term":[{"taxonomy":"project-type","embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project-type?post=1512"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}