{"id":1500,"date":"2025-02-23T16:12:08","date_gmt":"2025-02-23T16:12:08","guid":{"rendered":"https:\/\/apps.nhslothian.scot\/cirg\/?post_type=project&#038;p=1500"},"modified":"2025-08-18T13:07:00","modified_gmt":"2025-08-18T12:07:00","slug":"dexenceph","status":"publish","type":"project","link":"https:\/\/apps.nhslothian.scot\/cirg\/projects\/dexenceph\/","title":{"rendered":"DexEnceph"},"content":{"rendered":"\n<div class=\"wp-block-group alignfull fullstretch has-dark-accent-background-color has-background\" style=\"margin-top:0px;margin-bottom:0px;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-container-core-group-is-layout-0f86e333 wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-cover alignfull fullstretch cirgcover has-standard-white-color has-text-color has-link-color wp-elements-77863774b4bafa76017e3d0427e2b75c\" style=\"min-height:550px;aspect-ratio:unset;\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-dark-accent-background-color has-background-dim-100 has-background-dim\"><\/span><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"500\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/DexEnceph-Logo.jpg\" class=\"wp-block-cover__image-background wp-post-image\" alt=\"DexEnceph Logo\" data-object-fit=\"cover\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/DexEnceph-Logo.jpg 700w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/DexEnceph-Logo-300x214.jpg 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><div class=\"wp-block-cover__inner-container is-layout-constrained wp-container-core-cover-is-layout-ee2332cf wp-block-cover-is-layout-constrained\"><h1 style=\"margin-right:30px;margin-left:30px\" class=\"has-text-align-center has-link-color alignwide wp-elements-09e237a63bfe375a0171d5feb4e4df96 wp-block-post-title has-text-color has-standard-white-color\">DexEnceph<\/h1>\n\n<div class=\"has-text-align-center has-link-color cirg-screen-excerpt wp-elements-657dd3814347baad505828ae04cf4996 wp-block-post-excerpt has-text-color has-standard-white-color\"><p class=\"wp-block-post-excerpt__excerpt\">Dexamethasone in Herpes Simplex Virus Encephalitis Randomised Controlled Trial and Non-HSV Cohort Study <\/p><\/div><\/div><\/div>\n<\/div><\/div>\n\n\n<style>.kb-row-layout-id1500_259ec5-f4 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id1500_259ec5-f4 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id1500_259ec5-f4 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);max-width:1280px;margin-left:auto;margin-right:auto;padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, 1fr);}.kb-row-layout-id1500_259ec5-f4 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1500_259ec5-f4 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id1500_259ec5-f4 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1500_259ec5-f4 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-1-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column1500_8344f9-19 > .kt-inside-inner-col{display:flex;}.kadence-column1500_8344f9-19 > .kt-inside-inner-col{padding-top:35px;padding-right:30px;padding-bottom:40px;padding-left:30px;}.kadence-column1500_8344f9-19 > .kt-inside-inner-col,.kadence-column1500_8344f9-19 > .kt-inside-inner-col:before{border-top-left-radius:10px;border-top-right-radius:10px;border-bottom-right-radius:10px;border-bottom-left-radius:10px;}.kadence-column1500_8344f9-19 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1500_8344f9-19 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1500_8344f9-19 > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column1500_8344f9-19{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1500_8344f9-19{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1500_8344f9-19 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1500_8344f9-19 > .kt-inside-inner-col{background-color:#ffffff;}.kadence-column1500_8344f9-19 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1500_8344f9-19{position:relative;}.kadence-column1500_8344f9-19, .kt-inside-inner-col > .kadence-column1500_8344f9-19:not(.specificity){margin-top:-70px;margin-bottom:15px;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column1500_8344f9-19{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1500_8344f9-19{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1500_8344f9-19 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column1500_8344f9-19 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kt-row-column-wrap > .kadence-column1500_8344f9-19{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1500_8344f9-19{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1500_8344f9-19 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1500_8344f9-19 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1500_8344f9-19\"><div class=\"kt-inside-inner-col\"><style>.kb-row-layout-id1500_507f9b-7e > .kt-row-column-wrap{align-content:center;}:where(.kb-row-layout-id1500_507f9b-7e > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:center;}.kb-row-layout-id1500_507f9b-7e > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-lg, 3rem);grid-template-columns:repeat(2, minmax(0, 1fr));}.kb-row-layout-id1500_507f9b-7e > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1500_507f9b-7e > .kt-row-column-wrap{grid-template-columns:repeat(2, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id1500_507f9b-7e > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1500_507f9b-7e alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-middle\">\n<style>.kadence-column1500_89cbd5-fe > .kt-inside-inner-col,.kadence-column1500_89cbd5-fe > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1500_89cbd5-fe > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1500_89cbd5-fe > .kt-inside-inner-col{flex-direction:column;}.kadence-column1500_89cbd5-fe > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1500_89cbd5-fe > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1500_89cbd5-fe{position:relative;}@media all and (max-width: 1024px){.kadence-column1500_89cbd5-fe > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1500_89cbd5-fe > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1500_89cbd5-fe cirg-featured\"><div class=\"kt-inside-inner-col\"><figure style=\"aspect-ratio:auto\" class=\"wp-block-post-featured-image\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"500\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/DexEnceph-Logo.jpg\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image\" alt=\"DexEnceph Logo\" style=\"width:100%;height:100%;object-fit:cover;\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/DexEnceph-Logo.jpg 700w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/DexEnceph-Logo-300x214.jpg 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/figure><\/div><\/div>\n\n\n<style>.kadence-column1500_e4fb3e-34 > .kt-inside-inner-col,.kadence-column1500_e4fb3e-34 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1500_e4fb3e-34 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1500_e4fb3e-34 > .kt-inside-inner-col{flex-direction:column;}.kadence-column1500_e4fb3e-34 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1500_e4fb3e-34 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1500_e4fb3e-34{position:relative;}@media all and (max-width: 1024px){.kadence-column1500_e4fb3e-34 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1500_e4fb3e-34 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1500_e4fb3e-34\"><div class=\"kt-inside-inner-col\">\n<h2 class=\"wp-block-heading alignwide project-details-heading\">Project Details<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Start Date<br><strong>2017<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Status<br><strong>Open to Recruitment<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Principal Investigator<br><a href=\"\/cirg\/people\/dr-meghan-r-perry\/\">Dr Meghan R Perry<\/a><\/p>\n<\/div><\/div>\n\n<\/div><\/div>\n\n\n<p class=\"wp-block-paragraph\">Encephalitis means inflammation (swelling) of the brain, often caused by a virus. In the UK Herpes simplex virus (HSV) is the most prominent cause, affecting 1 per 250,000-500,000 people. Although classed as a very rare disease, it has a significant impact because survivors are incapacitated with severe disability, with estimated costs of \u00a33-5 million per severe case.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Inflammation and swelling occurs as part of the body\u2019s defence against infection. However in the brain it can cause damage, because the brain is in a fixed space (the skull) with no room for swelling. In herpes encephalitis (HSV encephalitis) the temporal lobes of the brain are especially affected. These lobes are very important for memory. Thus verbal memory is especially badly affected in HSV encephalitis. Verbal memory is the ability to remember the names of objects and people, and to listen to and recall spoken information Brain magnetic resonance imaging (MRI) scans can be used to assess brain swelling. Doctors sometimes give anti-inflammatory corticosteroid drugs (e.g. dexamethasone) to reduce the swelling. However, these drugs can also impair the immune defence system, potentially allowing uncontrolled virus replication. Thus we don\u2019t know whether or not giving corticosteroids is a good thing.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Does the corticosteroid drug dexamethasone improve verbal memory in HSVencephalitis by reducing brain temporal lobe swelling (as seen on brain scans)? The DexEnceph study will be conducted in 90 adults with HSV encephalitis across hospitals which are part of the Brain Infections UK Network. Half the patients with HSV encephalitis will receive corticosteroid, and the other half will not. When patients have blood tests, lumbar punctures, and brain scans we will collect images and samples for our study. Dexamethasone is given intravenously once a day for four days. It is a generally safe drug, given in several brain infections, with few short-term side effects. For the main outcome we will assess verbal memory at 6 months through neuropsychological testing. We will also examine swelling of the brain by MRI scanning. We will see if virus is detectable in the spinal fluid two weeks after admission. We will also examine the drug\u2019s effect on host immune proteins, and will examine neuropsychological and imaging outcomes at 18 months.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For those with non-HSV encephalitis, we will aim to identify &amp; understand the mechanisms causing encephalitis from the various etiologies.<\/p>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-1500_5cb8f3-64 .kt-block-spacer{height:80px;}.wp-block-kadence-spacer.kt-block-spacer-1500_5cb8f3-64 .kt-divider{border-top-width:3px;height:1px;border-top-color:#F59F68;width:100%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-1500_5cb8f3-64\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><hr class=\"kt-divider\" \/><\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>MAIN FUNDING BODY<\/strong><\/p>\n\n\n<style>.kb-row-layout-id1500_fa3d38-9c > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id1500_fa3d38-9c > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id1500_fa3d38-9c > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);}.kb-row-layout-id1500_fa3d38-9c > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}.kb-row-layout-id1500_fa3d38-9c > .kt-row-column-wrap{grid-template-columns:repeat(3, minmax(0, 1fr));}.kb-row-layout-id1500_fa3d38-9c > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1500_fa3d38-9c > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}}@media all and (max-width: 1024px){.kb-row-layout-id1500_fa3d38-9c > .kt-row-column-wrap{grid-template-columns:repeat(3, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id1500_fa3d38-9c > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}.kb-row-layout-id1500_fa3d38-9c > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1500_fa3d38-9c alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-3-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column1500_1d7c67-a8 > .kt-inside-inner-col,.kadence-column1500_1d7c67-a8 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1500_1d7c67-a8 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1500_1d7c67-a8 > .kt-inside-inner-col{flex-direction:column;}.kadence-column1500_1d7c67-a8 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1500_1d7c67-a8 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1500_1d7c67-a8{position:relative;}@media all and (max-width: 1024px){.kadence-column1500_1d7c67-a8 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1500_1d7c67-a8 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1500_1d7c67-a8\"><div class=\"kt-inside-inner-col\"><style>.kb-image1500_a7e4ec-99 .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image1500_a7e4ec-99 size-full\"><a href=\"https:\/\/www.liverpool.ac.uk\/\" class=\"kb-advanced-image-link\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"500\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/University-of-Liverpool-Logo.png\" alt=\"University of Liverpool Logo\" class=\"kb-img wp-image-1027\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/University-of-Liverpool-Logo.png 700w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/University-of-Liverpool-Logo-300x214.png 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/a><\/figure>\n<\/div><\/div>\n\n\n<style>.kadence-column1500_bf4f3e-6b > .kt-inside-inner-col,.kadence-column1500_bf4f3e-6b > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1500_bf4f3e-6b > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1500_bf4f3e-6b > .kt-inside-inner-col{flex-direction:column;}.kadence-column1500_bf4f3e-6b > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1500_bf4f3e-6b > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1500_bf4f3e-6b{position:relative;}@media all and (max-width: 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(max-width: 1024px){.kadence-column1500_f88b44-9c > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1500_f88b44-9c > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1500_f88b44-9c\"><div class=\"kt-inside-inner-col\"><\/div><\/div>\n\n<\/div><\/div>\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-3e41869c wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-icon__arrow-right\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/cirg\/projects\">See All Projects<span class=\"wp-block-button__link-icon\" aria-hidden=\"true\"><svg viewBox='0 0 16 11' xmlns='http:\/\/www.w3.org\/2000\/svg'><polygon points='0 4.7 13.1180124 4.7 9.44099379 1 10.4347826 0 16 5.5 10.4347826 11 9.44099379 10 13.1180124 6.3 0 6.3'><\/polygon><\/svg><\/span><\/a><\/div>\n<\/div>\n<\/div><\/div>\n\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Dexamethasone in Herpes Simplex Virus Encephalitis Randomised Controlled Trial and Non-HSV Cohort Study<\/p>\n","protected":false},"featured_media":1499,"menu_order":0,"template":"","meta":{"_acf_changed":false,"footnotes":""},"project-type":[20,21],"class_list":["post-1500","project","type-project","status-publish","has-post-thumbnail","hentry","project-type-core-science","project-type-past-project"],"acf":[],"_links":{"self":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project\/1500","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/types\/project"}],"version-history":[{"count":4,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project\/1500\/revisions"}],"predecessor-version":[{"id":2019,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project\/1500\/revisions\/2019"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/media\/1499"}],"wp:attachment":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/media?parent=1500"}],"wp:term":[{"taxonomy":"project-type","embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project-type?post=1500"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}