{"id":1495,"date":"2025-02-23T16:02:36","date_gmt":"2025-02-23T16:02:36","guid":{"rendered":"https:\/\/apps.nhslothian.scot\/cirg\/?post_type=project&#038;p=1495"},"modified":"2025-08-18T13:11:35","modified_gmt":"2025-08-18T12:11:35","slug":"vibrant","status":"publish","type":"project","link":"https:\/\/apps.nhslothian.scot\/cirg\/projects\/vibrant\/","title":{"rendered":"VIBRANT"},"content":{"rendered":"\n<div class=\"wp-block-group alignfull fullstretch has-dark-accent-background-color has-background\" style=\"margin-top:0px;margin-bottom:0px;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-container-core-group-is-layout-fb806a89 wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-cover alignfull fullstretch cirgcover has-standard-white-color has-text-color has-link-color wp-elements-77863774b4bafa76017e3d0427e2b75c\" style=\"min-height:550px;aspect-ratio:unset;\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-dark-accent-background-color has-background-dim-100 has-background-dim\"><\/span><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"500\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/VIBRANT-Logo.jpg\" class=\"wp-block-cover__image-background wp-post-image\" alt=\"VIBRANT Logo\" data-object-fit=\"cover\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/VIBRANT-Logo.jpg 700w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/VIBRANT-Logo-300x214.jpg 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><div class=\"wp-block-cover__inner-container is-layout-constrained wp-container-core-cover-is-layout-19e250f3 wp-block-cover-is-layout-constrained\"><h1 style=\"margin-right:30px;margin-left:30px;\" class=\"has-text-align-center has-link-color alignwide wp-elements-09e237a63bfe375a0171d5feb4e4df96 wp-block-post-title has-text-color has-standard-white-color\">VIBRANT<\/h1>\n\n<div class=\"has-text-align-center has-link-color cirg-screen-excerpt wp-elements-657dd3814347baad505828ae04cf4996 wp-block-post-excerpt has-text-color has-standard-white-color\"><p class=\"wp-block-post-excerpt__excerpt\">Vaccine Immunity Breakthrough &amp; Re-Infection &ndash; ANtibody &amp; T-cells <\/p><\/div><\/div><\/div>\n<\/div><\/div>\n\n\n<style>.kb-row-layout-id1495_b681a0-42 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id1495_b681a0-42 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id1495_b681a0-42 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);max-width:1280px;margin-left:auto;margin-right:auto;padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, 1fr);}.kb-row-layout-id1495_b681a0-42 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1495_b681a0-42 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id1495_b681a0-42 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1495_b681a0-42 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-1-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column1495_d3d211-5e > .kt-inside-inner-col{display:flex;}.kadence-column1495_d3d211-5e > .kt-inside-inner-col{padding-top:35px;padding-right:30px;padding-bottom:40px;padding-left:30px;}.kadence-column1495_d3d211-5e > .kt-inside-inner-col,.kadence-column1495_d3d211-5e > .kt-inside-inner-col:before{border-top-left-radius:10px;border-top-right-radius:10px;border-bottom-right-radius:10px;border-bottom-left-radius:10px;}.kadence-column1495_d3d211-5e > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1495_d3d211-5e > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1495_d3d211-5e > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column1495_d3d211-5e{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1495_d3d211-5e{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1495_d3d211-5e > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1495_d3d211-5e > .kt-inside-inner-col{background-color:#ffffff;}.kadence-column1495_d3d211-5e > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1495_d3d211-5e{position:relative;}.kadence-column1495_d3d211-5e, .kt-inside-inner-col > .kadence-column1495_d3d211-5e:not(.specificity){margin-top:-70px;margin-bottom:15px;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column1495_d3d211-5e{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1495_d3d211-5e{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1495_d3d211-5e > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column1495_d3d211-5e > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kt-row-column-wrap > .kadence-column1495_d3d211-5e{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1495_d3d211-5e{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1495_d3d211-5e > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1495_d3d211-5e > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1495_d3d211-5e\"><div class=\"kt-inside-inner-col\"><style>.kb-row-layout-id1495_5366bd-47 > .kt-row-column-wrap{align-content:center;}:where(.kb-row-layout-id1495_5366bd-47 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:center;}.kb-row-layout-id1495_5366bd-47 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-lg, 3rem);grid-template-columns:repeat(2, minmax(0, 1fr));}.kb-row-layout-id1495_5366bd-47 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1495_5366bd-47 > .kt-row-column-wrap{grid-template-columns:repeat(2, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id1495_5366bd-47 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1495_5366bd-47 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-middle\">\n<style>.kadence-column1495_dffda0-c5 > .kt-inside-inner-col,.kadence-column1495_dffda0-c5 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1495_dffda0-c5 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1495_dffda0-c5 > .kt-inside-inner-col{flex-direction:column;}.kadence-column1495_dffda0-c5 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1495_dffda0-c5 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1495_dffda0-c5{position:relative;}@media all and (max-width: 1024px){.kadence-column1495_dffda0-c5 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1495_dffda0-c5 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1495_dffda0-c5 cirg-featured\"><div class=\"kt-inside-inner-col\"><figure style=\"aspect-ratio:auto;\" class=\"wp-block-post-featured-image\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"500\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/VIBRANT-Logo.jpg\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image\" alt=\"VIBRANT Logo\" style=\"width:100%;height:100%;object-fit:cover;\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/VIBRANT-Logo.jpg 700w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/VIBRANT-Logo-300x214.jpg 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/figure><\/div><\/div>\n\n\n<style>.kadence-column1495_fa018a-1f > .kt-inside-inner-col,.kadence-column1495_fa018a-1f > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1495_fa018a-1f > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1495_fa018a-1f > .kt-inside-inner-col{flex-direction:column;}.kadence-column1495_fa018a-1f > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1495_fa018a-1f > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1495_fa018a-1f{position:relative;}@media all and (max-width: 1024px){.kadence-column1495_fa018a-1f > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1495_fa018a-1f > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1495_fa018a-1f\"><div class=\"kt-inside-inner-col\">\n<h2 class=\"wp-block-heading alignwide project-details-heading\">Project Details<\/h2>\n\n\n\n<p>Start Date<br><strong>August 2022<\/strong><\/p>\n\n\n\n<p>Status<br><strong>Closed to Recruitment &#8211; Follow Up Complete<\/strong><\/p>\n\n\n\n<p>Principal Investigator<br><a href=\"\/cirg\/people\/dr-kate-templeton\/\">Dr Kate Templeton<\/a><\/p>\n<\/div><\/div>\n\n<\/div><\/div>\n\n\n<p>Whether or not there is lasting immunity to COVID-19, induced by either vaccination or natural exposure, was a critical outstanding question in the COVID-19 pandemic. If the vaccines deployed in the UK fail(ed) to generate sufficient lasting immunity to either interrupt transmission or take the burden off acute health services, it will be essential to determine which measurable immune factors correlate with protection. This knowledge will form the basis of second-generation vaccine design and implementation policies, and will also inform future lockdown, shielding and vaccination policy, by identifying who is protected from re-infection and who is not.<\/p>\n\n\n\n<p>A key component to developing this understanding why some people experience vaccine breakthrough infections (new infections 14 days or more after their second COVID-19 vaccine), two or more infections (3 or more months apart) or fail to mount an antibody response following vaccination or natural infection. Understanding the mechanisms underpinning these events of interest, requires clinical, immune and genetic assessment and testing which was undertaken by the VIBRANT study and collaborators within the wider SIREN consortium. VIBRANT investigated for known and unknown underlying health conditions through a clinical health screening questionnaire and clinical sampling. VIBRANT also investigated immune and genomic signatures or biomarkers that are associated with vaccine failure. To do this VIBRANT integrated with several national platform studies (UKCIC, SIREN, ISARIC4C\/PHOSP, COG-UK, and HICC) which are collectively addressing the question of whether immune responses contribute to protection against re-infection.<\/p>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-1495_50e754-9e .kt-block-spacer{height:80px;}.wp-block-kadence-spacer.kt-block-spacer-1495_50e754-9e .kt-divider{border-top-width:3px;height:1px;border-top-color:#F59F68;width:100%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-1495_50e754-9e\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><hr class=\"kt-divider\" \/><\/div><\/div>\n\n\n\n<p><strong>MAIN FUNDING BODY<\/strong><\/p>\n\n\n<style>.kb-row-layout-id1495_06c32f-cc > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id1495_06c32f-cc > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id1495_06c32f-cc > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);}.kb-row-layout-id1495_06c32f-cc > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}.kb-row-layout-id1495_06c32f-cc > .kt-row-column-wrap{grid-template-columns:repeat(3, minmax(0, 1fr));}.kb-row-layout-id1495_06c32f-cc > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1495_06c32f-cc > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}}@media all and (max-width: 1024px){.kb-row-layout-id1495_06c32f-cc > .kt-row-column-wrap{grid-template-columns:repeat(3, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id1495_06c32f-cc > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}.kb-row-layout-id1495_06c32f-cc > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1495_06c32f-cc alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-3-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column1495_5d2b81-2c > .kt-inside-inner-col,.kadence-column1495_5d2b81-2c > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1495_5d2b81-2c > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1495_5d2b81-2c > .kt-inside-inner-col{flex-direction:column;}.kadence-column1495_5d2b81-2c > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1495_5d2b81-2c > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1495_5d2b81-2c{position:relative;}@media all and (max-width: 1024px){.kadence-column1495_5d2b81-2c > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1495_5d2b81-2c > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1495_5d2b81-2c\"><div class=\"kt-inside-inner-col\"><style>.kb-image1495_8abce2-20 .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image1495_8abce2-20 size-full\"><a href=\"https:\/\/www.ovg.ox.ac.uk\/\" class=\"kb-advanced-image-link\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"500\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/University-of-Oxford-Logo.jpg\" alt=\"University of Oxford Logo\" class=\"kb-img wp-image-1487\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/University-of-Oxford-Logo.jpg 700w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/University-of-Oxford-Logo-300x214.jpg 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/a><\/figure>\n<\/div><\/div>\n\n\n<style>.kadence-column1495_0f7a28-74 > .kt-inside-inner-col,.kadence-column1495_0f7a28-74 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1495_0f7a28-74 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1495_0f7a28-74 > .kt-inside-inner-col{flex-direction:column;}.kadence-column1495_0f7a28-74 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1495_0f7a28-74 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1495_0f7a28-74{position:relative;}@media all and (max-width: 1024px){.kadence-column1495_0f7a28-74 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1495_0f7a28-74 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1495_0f7a28-74\"><div class=\"kt-inside-inner-col\"><\/div><\/div>\n\n\n<style>.kadence-column1495_44a11a-c8 > .kt-inside-inner-col,.kadence-column1495_44a11a-c8 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1495_44a11a-c8 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1495_44a11a-c8 > .kt-inside-inner-col{flex-direction:column;}.kadence-column1495_44a11a-c8 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1495_44a11a-c8 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1495_44a11a-c8{position:relative;}@media all and (max-width: 1024px){.kadence-column1495_44a11a-c8 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1495_44a11a-c8 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1495_44a11a-c8\"><div class=\"kt-inside-inner-col\"><\/div><\/div>\n\n<\/div><\/div>\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-icon__arrow-right\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/cirg\/projects\">See All Projects<span class=\"wp-block-button__link-icon\" aria-hidden=\"true\"><svg viewBox='0 0 16 11' xmlns='http:\/\/www.w3.org\/2000\/svg'><polygon points='0 4.7 13.1180124 4.7 9.44099379 1 10.4347826 0 16 5.5 10.4347826 11 9.44099379 10 13.1180124 6.3 0 6.3'><\/polygon><\/svg><\/span><\/a><\/div>\n<\/div>\n<\/div><\/div>\n\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Vaccine Immunity Breakthrough &amp; Re-Infection \u2013 ANtibody &amp; T-cells<\/p>\n","protected":false},"featured_media":1496,"menu_order":0,"template":"","meta":{"_acf_changed":false,"footnotes":""},"project-type":[20,21],"class_list":["post-1495","project","type-project","status-publish","has-post-thumbnail","hentry","project-type-core-science","project-type-past-project"],"acf":[],"_links":{"self":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project\/1495","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/types\/project"}],"version-history":[{"count":4,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project\/1495\/revisions"}],"predecessor-version":[{"id":2021,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project\/1495\/revisions\/2021"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/media\/1496"}],"wp:attachment":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/media?parent=1495"}],"wp:term":[{"taxonomy":"project-type","embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project-type?post=1495"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}