{"id":1489,"date":"2025-02-22T22:33:46","date_gmt":"2025-02-22T22:33:46","guid":{"rendered":"https:\/\/apps.nhslothian.scot\/cirg\/?post_type=project&#038;p=1489"},"modified":"2025-08-18T13:09:30","modified_gmt":"2025-08-18T12:09:30","slug":"ionoe","status":"publish","type":"project","link":"https:\/\/apps.nhslothian.scot\/cirg\/projects\/ionoe\/","title":{"rendered":"IONOE"},"content":{"rendered":"\n<div class=\"wp-block-group alignfull fullstretch has-dark-accent-background-color has-background\" style=\"margin-top:0px;margin-bottom:0px;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-container-core-group-is-layout-fb806a89 wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-cover alignfull fullstretch cirgcover has-standard-white-color has-text-color has-link-color wp-elements-77863774b4bafa76017e3d0427e2b75c\" style=\"min-height:550px;aspect-ratio:unset;\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-dark-accent-background-color has-background-dim-100 has-background-dim\"><\/span><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"500\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/IONOE-Logo.jpg\" class=\"wp-block-cover__image-background wp-post-image\" alt=\"IONOE Logo\" data-object-fit=\"cover\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/IONOE-Logo.jpg 700w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/IONOE-Logo-300x214.jpg 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><div class=\"wp-block-cover__inner-container is-layout-constrained wp-container-core-cover-is-layout-19e250f3 wp-block-cover-is-layout-constrained\"><h1 style=\"margin-right:30px;margin-left:30px;\" class=\"has-text-align-center has-link-color alignwide wp-elements-09e237a63bfe375a0171d5feb4e4df96 wp-block-post-title has-text-color has-standard-white-color\">IONOE<\/h1>\n\n<div class=\"has-text-align-center has-link-color cirg-screen-excerpt wp-elements-657dd3814347baad505828ae04cf4996 wp-block-post-excerpt has-text-color has-standard-white-color\"><p class=\"wp-block-post-excerpt__excerpt\">Improving Outcomes of Necrotising Otitis Externa <\/p><\/div><\/div><\/div>\n<\/div><\/div>\n\n\n<style>.kb-row-layout-id1489_f0518c-ca > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id1489_f0518c-ca > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id1489_f0518c-ca > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);max-width:1280px;margin-left:auto;margin-right:auto;padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, 1fr);}.kb-row-layout-id1489_f0518c-ca > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1489_f0518c-ca > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id1489_f0518c-ca > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1489_f0518c-ca alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-1-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column1489_deb964-4f > .kt-inside-inner-col{display:flex;}.kadence-column1489_deb964-4f > .kt-inside-inner-col{padding-top:35px;padding-right:30px;padding-bottom:40px;padding-left:30px;}.kadence-column1489_deb964-4f > .kt-inside-inner-col,.kadence-column1489_deb964-4f > .kt-inside-inner-col:before{border-top-left-radius:10px;border-top-right-radius:10px;border-bottom-right-radius:10px;border-bottom-left-radius:10px;}.kadence-column1489_deb964-4f > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1489_deb964-4f > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1489_deb964-4f > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column1489_deb964-4f{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1489_deb964-4f{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1489_deb964-4f > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1489_deb964-4f > .kt-inside-inner-col{background-color:#ffffff;}.kadence-column1489_deb964-4f > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1489_deb964-4f{position:relative;}.kadence-column1489_deb964-4f, .kt-inside-inner-col > .kadence-column1489_deb964-4f:not(.specificity){margin-top:-70px;margin-bottom:15px;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column1489_deb964-4f{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1489_deb964-4f{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1489_deb964-4f > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column1489_deb964-4f > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kt-row-column-wrap > .kadence-column1489_deb964-4f{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1489_deb964-4f{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1489_deb964-4f > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1489_deb964-4f > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1489_deb964-4f\"><div class=\"kt-inside-inner-col\"><style>.kb-row-layout-id1489_b93fa6-9d > .kt-row-column-wrap{align-content:center;}:where(.kb-row-layout-id1489_b93fa6-9d > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:center;}.kb-row-layout-id1489_b93fa6-9d > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-lg, 3rem);grid-template-columns:repeat(2, minmax(0, 1fr));}.kb-row-layout-id1489_b93fa6-9d > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1489_b93fa6-9d > .kt-row-column-wrap{grid-template-columns:repeat(2, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id1489_b93fa6-9d > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1489_b93fa6-9d alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-middle\">\n<style>.kadence-column1489_932423-aa > .kt-inside-inner-col,.kadence-column1489_932423-aa > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1489_932423-aa > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1489_932423-aa > .kt-inside-inner-col{flex-direction:column;}.kadence-column1489_932423-aa > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1489_932423-aa > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1489_932423-aa{position:relative;}@media all and (max-width: 1024px){.kadence-column1489_932423-aa > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1489_932423-aa > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1489_932423-aa cirg-featured\"><div class=\"kt-inside-inner-col\"><figure style=\"aspect-ratio:auto;\" class=\"wp-block-post-featured-image\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"500\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/IONOE-Logo.jpg\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image\" alt=\"IONOE Logo\" style=\"width:100%;height:100%;object-fit:cover;\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/IONOE-Logo.jpg 700w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/IONOE-Logo-300x214.jpg 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/figure><\/div><\/div>\n\n\n<style>.kadence-column1489_fe8cef-f3 > .kt-inside-inner-col,.kadence-column1489_fe8cef-f3 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1489_fe8cef-f3 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1489_fe8cef-f3 > .kt-inside-inner-col{flex-direction:column;}.kadence-column1489_fe8cef-f3 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1489_fe8cef-f3 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1489_fe8cef-f3{position:relative;}@media all and (max-width: 1024px){.kadence-column1489_fe8cef-f3 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1489_fe8cef-f3 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1489_fe8cef-f3\"><div class=\"kt-inside-inner-col\">\n<h2 class=\"wp-block-heading alignwide project-details-heading\">Project Details<\/h2>\n\n\n\n<p>Start Date<br><strong>August 2022<\/strong><\/p>\n\n\n\n<p>Status<br><strong>Closed to Recruitment<\/strong><\/p>\n\n\n\n<p>Principal Investigator<br><a href=\"\/cirg\/people\/dr-rebecca-k-sutherland\/\">Dr Rebecca K Sutherland<\/a><\/p>\n<\/div><\/div>\n\n<\/div><\/div>\n\n\n<p>Necrotising Otitis Externa (NOE for short) is a severe ear infection that causes bad ear pain and hearing loss. Older people are particularly likely to get NOE, but it can also affect those with diabetes or a poor immune system.<\/p>\n\n\n\n<p>In the worst cases, NOE leads to permanent paralysis of part of the face or long-term problems swallowing. The standard treatment offered is antibiotics, but this treatment itself can cause problems: older people might have to stay in a hospital to have the antibiotics delivered through a tube into their veins, and they are also at greater risk of antibiotic side-effects, especially if they have to take them for a long time (as is often the case with NOE). All of this means that, about 14% of people affected do not respond well to the treatment and die.<\/p>\n\n\n\n<p>Despite this, and despite the recent increase in the number of people with NOE, there are no national or international guidelines for how to diagnose or treat NOE. As our population ages, more people are likely to get NOE, and so we have set up a network of more than 80 doctors to help us study NOE. This is the first group of specialists to work on NOE together internationally.<\/p>\n\n\n\n<p>In this study, specialists working at a number of hospitals in the UK will keep detailed records of how they diagnose and treat NOE, and whether the treatment works. We will analyse this information to find out the risk factors for NOE, which scans and surgical samples are the best way to diagnose this disease, and which type and dose of antibiotics work best. Doctors currently do not know what is the best way to manage NOE, with different people trying different things \u2013 we hope that our analysis will formulate the optimal strategy for managing NOE and improve outcomes.<\/p>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-1489_cdcbb8-3a .kt-block-spacer{height:80px;}.wp-block-kadence-spacer.kt-block-spacer-1489_cdcbb8-3a .kt-divider{border-top-width:3px;height:1px;border-top-color:#F59F68;width:100%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-1489_cdcbb8-3a\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><hr class=\"kt-divider\" \/><\/div><\/div>\n\n\n\n<p><strong>MAIN FUNDING BODY<\/strong><\/p>\n\n\n<style>.kb-row-layout-id1489_dfdba9-63 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id1489_dfdba9-63 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id1489_dfdba9-63 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);}.kb-row-layout-id1489_dfdba9-63 > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}.kb-row-layout-id1489_dfdba9-63 > .kt-row-column-wrap{grid-template-columns:repeat(3, minmax(0, 1fr));}.kb-row-layout-id1489_dfdba9-63 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1489_dfdba9-63 > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}}@media all and (max-width: 1024px){.kb-row-layout-id1489_dfdba9-63 > .kt-row-column-wrap{grid-template-columns:repeat(3, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id1489_dfdba9-63 > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}.kb-row-layout-id1489_dfdba9-63 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1489_dfdba9-63 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-3-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column1489_c4107e-cb > .kt-inside-inner-col,.kadence-column1489_c4107e-cb > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1489_c4107e-cb > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1489_c4107e-cb > .kt-inside-inner-col{flex-direction:column;}.kadence-column1489_c4107e-cb > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1489_c4107e-cb > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1489_c4107e-cb{position:relative;}@media all and (max-width: 1024px){.kadence-column1489_c4107e-cb > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1489_c4107e-cb > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1489_c4107e-cb\"><div class=\"kt-inside-inner-col\"><style>.kb-image1489_5f6fce-73 .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image1489_5f6fce-73 size-full\"><a href=\"https:\/\/www.ox.ac.uk\/\" class=\"kb-advanced-image-link\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"500\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/University-of-Oxford-Logo.jpg\" alt=\"University of Oxford Logo\" class=\"kb-img wp-image-1487\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/University-of-Oxford-Logo.jpg 700w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/University-of-Oxford-Logo-300x214.jpg 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/a><\/figure>\n<\/div><\/div>\n\n\n<style>.kadence-column1489_85c32d-13 > .kt-inside-inner-col,.kadence-column1489_85c32d-13 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1489_85c32d-13 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1489_85c32d-13 > .kt-inside-inner-col{flex-direction:column;}.kadence-column1489_85c32d-13 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1489_85c32d-13 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1489_85c32d-13{position:relative;}@media all and (max-width: 1024px){.kadence-column1489_85c32d-13 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1489_85c32d-13 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1489_85c32d-13\"><div class=\"kt-inside-inner-col\"><\/div><\/div>\n\n\n<style>.kadence-column1489_10d9e5-68 > .kt-inside-inner-col,.kadence-column1489_10d9e5-68 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1489_10d9e5-68 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1489_10d9e5-68 > .kt-inside-inner-col{flex-direction:column;}.kadence-column1489_10d9e5-68 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1489_10d9e5-68 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1489_10d9e5-68{position:relative;}@media all and (max-width: 1024px){.kadence-column1489_10d9e5-68 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1489_10d9e5-68 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1489_10d9e5-68\"><div class=\"kt-inside-inner-col\"><\/div><\/div>\n\n<\/div><\/div>\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-icon__arrow-right\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/cirg\/projects\">See All Projects<span class=\"wp-block-button__link-icon\" aria-hidden=\"true\"><svg viewBox='0 0 16 11' xmlns='http:\/\/www.w3.org\/2000\/svg'><polygon points='0 4.7 13.1180124 4.7 9.44099379 1 10.4347826 0 16 5.5 10.4347826 11 9.44099379 10 13.1180124 6.3 0 6.3'><\/polygon><\/svg><\/span><\/a><\/div>\n<\/div>\n<\/div><\/div>\n\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Improving Outcomes of Necrotising Otitis Externa<\/p>\n","protected":false},"featured_media":1488,"menu_order":0,"template":"","meta":{"_acf_changed":false,"footnotes":""},"project-type":[20,21],"class_list":["post-1489","project","type-project","status-publish","has-post-thumbnail","hentry","project-type-core-science","project-type-past-project"],"acf":[],"_links":{"self":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project\/1489","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/types\/project"}],"version-history":[{"count":3,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project\/1489\/revisions"}],"predecessor-version":[{"id":2020,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project\/1489\/revisions\/2020"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/media\/1488"}],"wp:attachment":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/media?parent=1489"}],"wp:term":[{"taxonomy":"project-type","embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project-type?post=1489"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}