{"id":1352,"date":"2025-02-10T22:14:56","date_gmt":"2025-02-10T22:14:56","guid":{"rendered":"https:\/\/apps.nhslothian.scot\/cirg\/?post_type=project&#038;p=1352"},"modified":"2026-03-23T17:06:38","modified_gmt":"2026-03-23T17:06:38","slug":"isaric-4c","status":"publish","type":"project","link":"https:\/\/apps.nhslothian.scot\/cirg\/projects\/isaric-4c\/","title":{"rendered":"ISARIC 4C"},"content":{"rendered":"\n<div class=\"wp-block-group alignfull fullstretch has-dark-accent-background-color has-background\" style=\"margin-top:0px;margin-bottom:0px;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-container-core-group-is-layout-0f86e333 wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-cover alignfull fullstretch cirgcover has-standard-white-color has-text-color has-link-color wp-elements-77863774b4bafa76017e3d0427e2b75c\" style=\"min-height:550px;aspect-ratio:unset;\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-dark-accent-background-color has-background-dim-100 has-background-dim\"><\/span><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"500\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/Isaric-4C-Logo.png\" class=\"wp-block-cover__image-background wp-post-image\" alt=\"Isaric 4C Logo\" data-object-fit=\"cover\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/Isaric-4C-Logo.png 700w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/Isaric-4C-Logo-300x214.png 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><div class=\"wp-block-cover__inner-container is-layout-constrained wp-container-core-cover-is-layout-ee2332cf wp-block-cover-is-layout-constrained\"><h1 style=\"margin-right:30px;margin-left:30px\" class=\"has-text-align-center has-link-color alignwide wp-elements-09e237a63bfe375a0171d5feb4e4df96 wp-block-post-title has-text-color has-standard-white-color\">ISARIC 4C<\/h1>\n\n<div class=\"has-text-align-center has-link-color cirg-screen-excerpt wp-elements-657dd3814347baad505828ae04cf4996 wp-block-post-excerpt has-text-color has-standard-white-color\"><p class=\"wp-block-post-excerpt__excerpt\">ISARIC\/WHO Clinical Characterisation Protocol for Severe Emerging Infections in the UK (CCP-UK) (Scotland) <\/p><\/div><\/div><\/div>\n<\/div><\/div>\n\n\n<style>.kb-row-layout-id1352_aba3f7-e3 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id1352_aba3f7-e3 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id1352_aba3f7-e3 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);max-width:1280px;margin-left:auto;margin-right:auto;padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, 1fr);}.kb-row-layout-id1352_aba3f7-e3 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1352_aba3f7-e3 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id1352_aba3f7-e3 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1352_aba3f7-e3 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-1-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column1352_37fc46-11 > .kt-inside-inner-col{display:flex;}.kadence-column1352_37fc46-11 > .kt-inside-inner-col{padding-top:35px;padding-right:30px;padding-bottom:40px;padding-left:30px;}.kadence-column1352_37fc46-11 > .kt-inside-inner-col,.kadence-column1352_37fc46-11 > .kt-inside-inner-col:before{border-top-left-radius:10px;border-top-right-radius:10px;border-bottom-right-radius:10px;border-bottom-left-radius:10px;}.kadence-column1352_37fc46-11 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1352_37fc46-11 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1352_37fc46-11 > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column1352_37fc46-11{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1352_37fc46-11{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1352_37fc46-11 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1352_37fc46-11 > .kt-inside-inner-col{background-color:#ffffff;}.kadence-column1352_37fc46-11 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1352_37fc46-11{position:relative;}.kadence-column1352_37fc46-11, .kt-inside-inner-col > .kadence-column1352_37fc46-11:not(.specificity){margin-top:-70px;margin-bottom:15px;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column1352_37fc46-11{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1352_37fc46-11{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1352_37fc46-11 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column1352_37fc46-11 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kt-row-column-wrap > 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3rem);grid-template-columns:repeat(2, minmax(0, 1fr));}.kb-row-layout-id1352_56a4d9-b7 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1352_56a4d9-b7 > .kt-row-column-wrap{grid-template-columns:repeat(2, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id1352_56a4d9-b7 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1352_56a4d9-b7 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-middle\">\n<style>.kadence-column1352_1f4c22-89 > .kt-inside-inner-col,.kadence-column1352_1f4c22-89 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1352_1f4c22-89 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1352_1f4c22-89 > .kt-inside-inner-col{flex-direction:column;}.kadence-column1352_1f4c22-89 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1352_1f4c22-89 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1352_1f4c22-89{position:relative;}@media all and (max-width: 1024px){.kadence-column1352_1f4c22-89 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1352_1f4c22-89 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1352_1f4c22-89 cirg-featured\"><div class=\"kt-inside-inner-col\"><figure style=\"aspect-ratio:auto\" class=\"wp-block-post-featured-image\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"500\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/Isaric-4C-Logo.png\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image\" alt=\"Isaric 4C Logo\" style=\"width:100%;height:100%;object-fit:cover;\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/Isaric-4C-Logo.png 700w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/Isaric-4C-Logo-300x214.png 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/figure><\/div><\/div>\n\n\n<style>.kadence-column1352_b92491-88 > .kt-inside-inner-col,.kadence-column1352_b92491-88 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1352_b92491-88 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1352_b92491-88 > .kt-inside-inner-col{flex-direction:column;}.kadence-column1352_b92491-88 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1352_b92491-88 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1352_b92491-88{position:relative;}@media all and (max-width: 1024px){.kadence-column1352_b92491-88 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1352_b92491-88 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1352_b92491-88\"><div class=\"kt-inside-inner-col\">\n<h2 class=\"wp-block-heading alignwide project-details-heading\">Project Details<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Start Date<br><strong>2020<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Status<br><strong>Recruiting<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Principal Investigator<br><a href=\"\/cirg\/people\/dr-oliver-koch\/\">Dr Oliver Koch<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Main Research Site<br><strong>WGH<\/strong><\/p>\n<\/div><\/div>\n\n<\/div><\/div>\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/isaric4c.net\/\" target=\"_blank\" rel=\"noreferrer noopener\">ISARIC 4C<\/a>&nbsp;(International Severe Acute Respiratory Infection Consortium- Coronavirus Clinical Characterisation Consortium) is a UK-wide coalition of doctors, hospital staff and scientists committed to answering urgent questions about COVID-19 quickly, openly and for public benefit. For example:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>What puts people at higher risk of severe COVID-19?<\/li>\n\n\n\n<li>What is the best way to diagnose the disease?<\/li>\n\n\n\n<li>Do other respiratory infections affect the severity of COVID-19?<\/li>\n\n\n\n<li>In some patients, does the immune response do more harm than good?<\/li>\n\n\n\n<li>Who should be treated with which drugs, and when? Are some drugs harmful?<\/li>\n\n\n\n<li>How long are people infectious, and how?<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">ISARIC 4C investigators have been preparing for a respiratory pandemic for over 8 years. This period of preparation enabled the immediate launch of a WHO-approved Clinical Characterisation Protocol (CCP) that was developed in the aftermath of the 2009-10 influenza pandemic. With these plans in place, ISARIC 4C investigators recruited from the very start of the COVID-19 pandemic and has been collecting data and samples ever since.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As of 26 October, ISARIC 4C have recruited 87,729 cases and have biological sampling on over 2,500 of them and has already&nbsp;produced many results.<\/p>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-1352_ce8888-f8 .kt-block-spacer{height:80px;}.wp-block-kadence-spacer.kt-block-spacer-1352_ce8888-f8 .kt-divider{border-top-width:3px;height:1px;border-top-color:#F59F68;width:100%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-1352_ce8888-f8\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><hr class=\"kt-divider\" \/><\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>MAIN FUNDING BODY<\/strong><\/p>\n\n\n<style>.kb-row-layout-id1352_c0d39c-ad > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id1352_c0d39c-ad > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id1352_c0d39c-ad > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);}.kb-row-layout-id1352_c0d39c-ad > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}.kb-row-layout-id1352_c0d39c-ad > .kt-row-column-wrap{grid-template-columns:repeat(3, minmax(0, 1fr));}.kb-row-layout-id1352_c0d39c-ad > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1352_c0d39c-ad > .kt-row-column-wrap > div:not(.added-for-specificity){grid-column:initial;}}@media all and (max-width: 1024px){.kb-row-layout-id1352_c0d39c-ad > .kt-row-column-wrap{grid-template-columns:repeat(3, minmax(0, 1fr));}}@media all and (max-width: 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.kt-inside-inner-col:before{opacity:0.3;}.kadence-column1352_b7521c-b4{position:relative;}@media all and (max-width: 1024px){.kadence-column1352_b7521c-b4 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1352_b7521c-b4 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1352_b7521c-b4\"><div class=\"kt-inside-inner-col\"><style>.kb-image1352_bb44be-00 .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image1352_bb44be-00 size-full\"><a href=\"https:\/\/www.liverpool.ac.uk\/\" class=\"kb-advanced-image-link\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"500\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/University-of-Liverpool-Logo.png\" alt=\"University of Liverpool Logo\" class=\"kb-img wp-image-1027\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/University-of-Liverpool-Logo.png 700w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/University-of-Liverpool-Logo-300x214.png 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/a><\/figure>\n<\/div><\/div>\n\n\n<style>.kadence-column1352_af9e71-ce > .kt-inside-inner-col,.kadence-column1352_af9e71-ce > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1352_af9e71-ce > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1352_af9e71-ce > .kt-inside-inner-col{flex-direction:column;}.kadence-column1352_af9e71-ce > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1352_af9e71-ce > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1352_af9e71-ce{position:relative;}@media all and (max-width: 1024px){.kadence-column1352_af9e71-ce > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1352_af9e71-ce > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1352_af9e71-ce\"><div class=\"kt-inside-inner-col\"><\/div><\/div>\n\n\n<style>.kadence-column1352_62a813-ae > .kt-inside-inner-col,.kadence-column1352_62a813-ae > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1352_62a813-ae > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1352_62a813-ae > .kt-inside-inner-col{flex-direction:column;}.kadence-column1352_62a813-ae > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1352_62a813-ae > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1352_62a813-ae{position:relative;}@media all and (max-width: 1024px){.kadence-column1352_62a813-ae > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column1352_62a813-ae > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1352_62a813-ae\"><div class=\"kt-inside-inner-col\"><\/div><\/div>\n\n<\/div><\/div>\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-3e41869c wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-icon__arrow-right\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/cirg\/projects\">See All Projects<span class=\"wp-block-button__link-icon\" aria-hidden=\"true\"><svg viewBox='0 0 16 11' xmlns='http:\/\/www.w3.org\/2000\/svg'><polygon points='0 4.7 13.1180124 4.7 9.44099379 1 10.4347826 0 16 5.5 10.4347826 11 9.44099379 10 13.1180124 6.3 0 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(Scotland)<\/p>\n","protected":false},"featured_media":1026,"menu_order":0,"template":"","meta":{"_acf_changed":false,"footnotes":""},"project-type":[19,21],"class_list":["post-1352","project","type-project","status-publish","has-post-thumbnail","hentry","project-type-clinical-trials","project-type-past-project"],"acf":[],"_links":{"self":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project\/1352","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/types\/project"}],"version-history":[{"count":4,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project\/1352\/revisions"}],"predecessor-version":[{"id":2024,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project\/1352\/revisions\/2024"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/media\/1026"}],"wp:attachment":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/media?parent=1352"}],"wp:term":[{"taxonomy":"project-type","embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/project-type?post=1352"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}