{"id":2234,"date":"2026-09-17T11:47:45","date_gmt":"2026-09-17T10:47:45","guid":{"rendered":"https:\/\/apps.nhslothian.scot\/cirg\/?p=2234"},"modified":"2026-09-17T11:48:04","modified_gmt":"2026-09-17T10:48:04","slug":"exciting-new-publication-in-nature-medicine","status":"publish","type":"post","link":"https:\/\/apps.nhslothian.scot\/cirg\/exciting-new-publication-in-nature-medicine\/","title":{"rendered":"Exciting new publication in Nature Medicine"},"content":{"rendered":"<style>.kb-row-layout-id2234_661c41-c1 > .kt-row-column-wrap{align-content:center;}:where(.kb-row-layout-id2234_661c41-c1 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:center;}.kb-row-layout-id2234_661c41-c1 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);max-width:1520px;padding-top:60px;padding-right:60px;padding-bottom:100px;padding-left:60px;min-height:450px;grid-template-columns:repeat(2, minmax(0, 1fr));}.kb-row-layout-id2234_661c41-c1 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id2234_661c41-c1 > .kt-row-column-wrap{row-gap:var(--global-kb-gap-md, 2rem);padding-bottom:130px;grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id2234_661c41-c1 > .kt-row-column-wrap{row-gap:var(--global-kb-gap-md, 2rem);padding-right:15px;padding-bottom:150px;padding-left:15px;grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id2234_661c41-c1 alignfull has-dark-accent-background-color kt-row-has-bg fullstretch wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-row kt-mobile-layout-row kt-row-valign-middle kb-theme-content-width\">\n<style>.kadence-column2234_20debf-7a > .kt-inside-inner-col{display:flex;}.kadence-column2234_20debf-7a > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2234_20debf-7a > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}.kadence-column2234_20debf-7a > .kt-inside-inner-col > .kb-image-is-ratio-size{align-self:stretch;}.kadence-column2234_20debf-7a > .kt-inside-inner-col > .wp-block-kadence-advancedgallery{align-self:stretch;}.kadence-column2234_20debf-7a > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column2234_20debf-7a{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column2234_20debf-7a{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column2234_20debf-7a > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column2234_20debf-7a > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2234_20debf-7a{position:relative;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column2234_20debf-7a{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column2234_20debf-7a{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column2234_20debf-7a > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column2234_20debf-7a > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}}@media all and (max-width: 767px){.kt-row-column-wrap > .kadence-column2234_20debf-7a{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column2234_20debf-7a{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column2234_20debf-7a > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column2234_20debf-7a > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2234_20debf-7a\"><div class=\"kt-inside-inner-col\"><figure class=\"wp-block-post-featured-image\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"500\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/RIO-Logo.jpg\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image\" alt=\"RIO Logo\" style=\"border-radius:12px;object-fit:cover;\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/RIO-Logo.jpg 700w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/RIO-Logo-300x214.jpg 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/figure><\/div><\/div>\n\n\n<style>.kadence-column2234_577d03-3e > .kt-inside-inner-col{display:flex;}.kadence-column2234_577d03-3e > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2234_577d03-3e > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}.kadence-column2234_577d03-3e > .kt-inside-inner-col > .kb-image-is-ratio-size{align-self:stretch;}.kadence-column2234_577d03-3e > .kt-inside-inner-col > .wp-block-kadence-advancedgallery{align-self:stretch;}.kadence-column2234_577d03-3e > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column2234_577d03-3e{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column2234_577d03-3e{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column2234_577d03-3e > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column2234_577d03-3e > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2234_577d03-3e{position:relative;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column2234_577d03-3e{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column2234_577d03-3e{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column2234_577d03-3e > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column2234_577d03-3e > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}}@media all and (max-width: 767px){.kt-row-column-wrap > .kadence-column2234_577d03-3e{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column2234_577d03-3e{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column2234_577d03-3e > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column2234_577d03-3e > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2234_577d03-3e\"><div class=\"kt-inside-inner-col\"><h1 style=\"margin-right:30px;margin-left:30px\" class=\"has-link-color alignwide wp-elements-1 wp-block-post-title has-text-color has-standard-white-color has-text-align-center\">Exciting new publication in Nature Medicine<\/h1>\n\n<div class=\"has-link-color cirg-screen-excerpt wp-elements-2 wp-block-post-excerpt has-text-color has-standard-white-color has-text-align-center\"><p class=\"wp-block-post-excerpt__excerpt\">Secondary and Exploratory Outcomes of the Rio Trial Published <\/p><\/div>\n\n<div style=\"font-style:normal;font-weight:700;text-transform:uppercase;border-radius:50px;padding-top:9px;padding-bottom:9px;padding-left:20px;padding-right:20px\" class=\"has-link-color cirg-news-page-date wp-elements-3 wp-block-post-date has-text-color has-standard-white-color has-background has-accent-plum-background-color has-text-align-center\"><time datetime=\"2026-09-17T11:47:45+01:00\">17 September 2026<\/time><\/div><\/div><\/div>\n\n<\/div><\/div>\n\n<style>.kb-row-layout-id2234_ff1324-a7 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id2234_ff1324-a7 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id2234_ff1324-a7 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);max-width:1280px;margin-left:auto;margin-right:auto;padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, 1fr);}.kb-row-layout-id2234_ff1324-a7 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id2234_ff1324-a7 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id2234_ff1324-a7 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id2234_ff1324-a7 alignnone cirg-news-wrapper wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-1-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column2234_56db06-2d > .kt-inside-inner-col{display:flex;}.kadence-column2234_56db06-2d > .kt-inside-inner-col{padding-top:35px;padding-right:30px;padding-bottom:40px;padding-left:30px;}.kadence-column2234_56db06-2d > .kt-inside-inner-col,.kadence-column2234_56db06-2d > .kt-inside-inner-col:before{border-top-left-radius:10px;border-top-right-radius:10px;border-bottom-right-radius:10px;border-bottom-left-radius:10px;}.kadence-column2234_56db06-2d > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column2234_56db06-2d > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column2234_56db06-2d > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column2234_56db06-2d{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column2234_56db06-2d{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column2234_56db06-2d > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column2234_56db06-2d > .kt-inside-inner-col{background-color:#ffffff;}.kadence-column2234_56db06-2d > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column2234_56db06-2d{position:relative;}.kadence-column2234_56db06-2d, .kt-inside-inner-col > .kadence-column2234_56db06-2d:not(.specificity){margin-top:-70px;margin-bottom:15px;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column2234_56db06-2d{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column2234_56db06-2d{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column2234_56db06-2d > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column2234_56db06-2d > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kt-row-column-wrap > .kadence-column2234_56db06-2d{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column2234_56db06-2d{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column2234_56db06-2d > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column2234_56db06-2d > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column2234_56db06-2d\"><div class=\"kt-inside-inner-col\">\n<p class=\"wp-block-paragraph\">The RIO study is looking at whether a new bNAb treatment can keep viral load undetectable without antiretroviral treatment (ART) and involved asking all participants to stop ART for a short time.\u00a0<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The study aimed to measure how long viral load stays undetectable without ART, as well as  look at what happens to the HIV virus and immune system in blood samples. When virus becomes detectable in a blood test (viral rebound) the participants were then asked to re-start their ART.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This publication discusses the secondary outcomes of the Rio trial. it looks at viral rebound  antibody sensitivity and reservoir dynamics. The publication also looks at the exploratory outcomes of the trial which looked at rebound virus evolution and autologous antibody activity. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Read the publication here:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.nature.com\/articles\/s41591-026-04644-8\">Broadly neutralizing antibodies in adult males living with HIV undergoing analytical treatment interruption: secondary and exploratory outcomes of the phase II randomized controlled RIO trial<\/a><\/p>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-2234_60de26-b7 .kt-block-spacer{height:80px;}.wp-block-kadence-spacer.kt-block-spacer-2234_60de26-b7 .kt-divider{border-top-width:3px;height:1px;border-top-color:#F59F68;width:100%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-2234_60de26-b7\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><hr class=\"kt-divider\" \/><\/div><\/div>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-3e41869c wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-icon__arrow-right\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/cirg\/news\">SEE All News &amp; Events<span class=\"wp-block-button__link-icon\" aria-hidden=\"true\"><svg viewBox='0 0 16 11' xmlns='http:\/\/www.w3.org\/2000\/svg'><polygon points='0 4.7 13.1180124 4.7 9.44099379 1 10.4347826 0 16 5.5 10.4347826 11 9.44099379 10 13.1180124 6.3 0 6.3'><\/polygon><\/svg><\/span><\/a><\/div>\n<\/div>\n<\/div><\/div>\n\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Secondary and Exploratory Outcomes of the Rio Trial Published<\/p>\n","protected":false},"author":15,"featured_media":1510,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[15],"class_list":["post-2234","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"rttpg_featured_image_url":{"full":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/RIO-Logo.jpg",700,500,false],"landscape":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/RIO-Logo.jpg",700,500,false],"portraits":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/RIO-Logo.jpg",700,500,false],"thumbnail":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/RIO-Logo-150x150.jpg",150,150,true],"medium":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/RIO-Logo-300x214.jpg",300,214,true],"large":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/RIO-Logo.jpg",700,500,false],"1536x1536":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/RIO-Logo.jpg",700,500,false],"2048x2048":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/RIO-Logo.jpg",700,500,false],"post_slider_thumbnail":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/RIO-Logo.jpg",700,500,false]},"rttpg_author":{"display_name":"tallulaharmstrong","author_link":"https:\/\/apps.nhslothian.scot\/cirg\/author\/tallulaharmstrong\/"},"rttpg_comment":0,"rttpg_category":"<a href=\"https:\/\/apps.nhslothian.scot\/cirg\/category\/news\/\" rel=\"category tag\">News and Events<\/a>","rttpg_excerpt":"Secondary and Exploratory Outcomes of the Rio Trial Published","_links":{"self":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/posts\/2234","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/users\/15"}],"replies":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/comments?post=2234"}],"version-history":[{"count":1,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/posts\/2234\/revisions"}],"predecessor-version":[{"id":2235,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/posts\/2234\/revisions\/2235"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/media\/1510"}],"wp:attachment":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/media?parent=2234"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/categories?post=2234"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}