{"id":1779,"date":"2021-06-28T11:05:00","date_gmt":"2021-06-28T10:05:00","guid":{"rendered":"https:\/\/apps.nhslothian.scot\/cirg\/?p=1779"},"modified":"2025-03-02T21:44:28","modified_gmt":"2025-03-02T21:44:28","slug":"azd2816-trial-gets-underway","status":"publish","type":"post","link":"https:\/\/apps.nhslothian.scot\/cirg\/azd2816-trial-gets-underway\/","title":{"rendered":"AZD2816 Trial Gets Underway"},"content":{"rendered":"<style>.kb-row-layout-id1779_b82528-05 > .kt-row-column-wrap{align-content:center;}:where(.kb-row-layout-id1779_b82528-05 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:center;}.kb-row-layout-id1779_b82528-05 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);max-width:1520px;padding-top:60px;padding-right:60px;padding-bottom:100px;padding-left:60px;min-height:450px;grid-template-columns:repeat(2, minmax(0, 1fr));}.kb-row-layout-id1779_b82528-05 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1779_b82528-05 > .kt-row-column-wrap{row-gap:var(--global-kb-gap-md, 2rem);padding-bottom:130px;grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id1779_b82528-05 > .kt-row-column-wrap{row-gap:var(--global-kb-gap-md, 2rem);padding-right:15px;padding-bottom:150px;padding-left:15px;grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1779_b82528-05 alignfull has-dark-accent-background-color kt-row-has-bg fullstretch wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-row kt-mobile-layout-row kt-row-valign-middle kb-theme-content-width\">\n<style>.kadence-column1779_9377fc-e9 > .kt-inside-inner-col{display:flex;}.kadence-column1779_9377fc-e9 > .kt-inside-inner-col,.kadence-column1779_9377fc-e9 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1779_9377fc-e9 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1779_9377fc-e9 > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}.kadence-column1779_9377fc-e9 > .kt-inside-inner-col > .kb-image-is-ratio-size{align-self:stretch;}.kadence-column1779_9377fc-e9 > .kt-inside-inner-col > .wp-block-kadence-advancedgallery{align-self:stretch;}.kadence-column1779_9377fc-e9 > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column1779_9377fc-e9{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1779_9377fc-e9{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1779_9377fc-e9 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1779_9377fc-e9 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1779_9377fc-e9{position:relative;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column1779_9377fc-e9{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1779_9377fc-e9{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1779_9377fc-e9 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column1779_9377fc-e9 > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}}@media all and (max-width: 767px){.kt-row-column-wrap > .kadence-column1779_9377fc-e9{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1779_9377fc-e9{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1779_9377fc-e9 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1779_9377fc-e9 > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1779_9377fc-e9\"><div class=\"kt-inside-inner-col\"><figure class=\"wp-block-post-featured-image\"><img loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"576\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/Jenner_Institute_by_John_Cairns_20.11.20.jpg\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image\" alt=\"Jenner Institute by John Cairns 20.11.20\" style=\"border-radius:12px;object-fit:cover;\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/Jenner_Institute_by_John_Cairns_20.11.20.jpg 768w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/Jenner_Institute_by_John_Cairns_20.11.20-300x225.jpg 300w\" sizes=\"auto, (max-width: 768px) 100vw, 768px\" \/><\/figure><\/div><\/div>\n\n\n<style>.kadence-column1779_aed763-75 > .kt-inside-inner-col{display:flex;}.kadence-column1779_aed763-75 > .kt-inside-inner-col,.kadence-column1779_aed763-75 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1779_aed763-75 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1779_aed763-75 > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}.kadence-column1779_aed763-75 > .kt-inside-inner-col > .kb-image-is-ratio-size{align-self:stretch;}.kadence-column1779_aed763-75 > .kt-inside-inner-col > .wp-block-kadence-advancedgallery{align-self:stretch;}.kadence-column1779_aed763-75 > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column1779_aed763-75{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1779_aed763-75{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1779_aed763-75 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1779_aed763-75 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1779_aed763-75{position:relative;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column1779_aed763-75{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1779_aed763-75{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1779_aed763-75 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column1779_aed763-75 > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}}@media all and (max-width: 767px){.kt-row-column-wrap > .kadence-column1779_aed763-75{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1779_aed763-75{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1779_aed763-75 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1779_aed763-75 > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1779_aed763-75\"><div class=\"kt-inside-inner-col\"><h1 style=\"margin-right:30px;margin-left:30px;\" class=\"has-text-align-center has-link-color alignwide wp-elements-fcb699291ef6430427119bc2d1307555 wp-block-post-title has-text-color has-standard-white-color\">AZD2816 Trial Gets Underway<\/h1>\n\n<div class=\"has-text-align-center has-link-color cirg-screen-excerpt wp-elements-a8508ab0214aaef08ded30a066c8b76c wp-block-post-excerpt has-text-color has-standard-white-color\"><p class=\"wp-block-post-excerpt__excerpt\">AZD2816 is a modified version of the Oxford\/AstraZeneca COVID-19 vaccine, that has been made specific for the Beta SARS CoV-2 variant <\/p><\/div>\n\n<div style=\"font-style:normal;font-weight:700;text-transform:uppercase; border-radius:50px; padding-top:9px;padding-bottom:9px;padding-left:20px;padding-right:20px;\" class=\"has-text-align-center has-link-color cirg-news-page-date wp-elements-a1f8281b758fa992bda8a3d771af56d2 wp-block-post-date has-text-color has-standard-white-color has-background has-accent-plum-background-color\"><time datetime=\"2021-06-28T11:05:00+01:00\">28 June 2021<\/time><\/div><\/div><\/div>\n\n<\/div><\/div>\n\n<style>.kb-row-layout-id1779_9feb46-89 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id1779_9feb46-89 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id1779_9feb46-89 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);max-width:1280px;margin-left:auto;margin-right:auto;padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, 1fr);}.kb-row-layout-id1779_9feb46-89 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1779_9feb46-89 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id1779_9feb46-89 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1779_9feb46-89 alignnone cirg-news-wrapper wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-1-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column1779_62e942-14 > .kt-inside-inner-col{display:flex;}.kadence-column1779_62e942-14 > .kt-inside-inner-col{padding-top:35px;padding-right:30px;padding-bottom:40px;padding-left:30px;}.kadence-column1779_62e942-14 > .kt-inside-inner-col,.kadence-column1779_62e942-14 > .kt-inside-inner-col:before{border-top-left-radius:10px;border-top-right-radius:10px;border-bottom-right-radius:10px;border-bottom-left-radius:10px;}.kadence-column1779_62e942-14 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1779_62e942-14 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1779_62e942-14 > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column1779_62e942-14{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1779_62e942-14{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1779_62e942-14 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1779_62e942-14 > .kt-inside-inner-col{background-color:#ffffff;}.kadence-column1779_62e942-14 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1779_62e942-14{position:relative;}.kadence-column1779_62e942-14, .kt-inside-inner-col > .kadence-column1779_62e942-14:not(.specificity){margin-top:-70px;margin-bottom:15px;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column1779_62e942-14{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1779_62e942-14{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1779_62e942-14 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column1779_62e942-14 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kt-row-column-wrap > .kadence-column1779_62e942-14{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1779_62e942-14{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1779_62e942-14 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1779_62e942-14 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1779_62e942-14\"><div class=\"kt-inside-inner-col\">\n<p>The trial will recruit approximately 2,250 participants across UK, South Africa, Brazil and Poland. This includes 86 participants who have been recruited from across the Lothians at the Western General Hospital, with CIRGs\u00a0<a href=\"\/cirg\/people\/dr-matt-adam\/\">Dr Matthew Adam<\/a>\u00a0as the local Principal Investigator.<\/p>\n\n\n\n<p>AZD2816 will be administered to individuals who have previously been fully vaccinated with two doses of&nbsp;<em>Vaxzevria&nbsp;<\/em>or an mRNA vaccine, at least three months after their last injection. In non-vaccinated individuals, AZD2816 will be given as two doses, four or twelve weeks apart, or given as a second dose following a first dose of&nbsp;<em>Vaxzevria&nbsp;<\/em>four weeks apart.<\/p>\n\n\n\n<p>AZD2816 has been designed using the same adenoviral vector platform as&nbsp;<em>Vaxzevria<\/em>, with minor genetic alterations to the spike protein based on the Beta (B.1.351, South African) variant.<\/p>\n\n\n\n<p>Sir Mene Pangalos, Executive Vice President, BioPharmaceuticals R&amp;D, said: \u201cIt is important we continue to stay ahead of genetically distinct variants of the coronavirus. AZD2816 should help broaden individuals immune response against emerging variants of concern. Initiating the Phase II\/III trial for AZD2816 means we can be prepared should a variant vaccine be required in the future.\u201d<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\u201cTesting booster doses of existing vaccines and new variant vaccines is important to ensure we are best prepared to stay ahead of the coronavirus pandemic, should their use be needed.\u201d Professor Sir Andrew J Pollard, chief investigator and director of the Oxford Vaccine Group at the University of Oxford<\/p>\n<\/blockquote>\n\n\n\n<p>Initial data from the trial is expected later this year and, once available, will be submitted to regulators for assessment as a next-generation booster vaccine and through an expedited regulatory pathway.<\/p>\n\n\n\n<p><strong>D7220C00001<br><\/strong>D7220C00001 is a Phase II\/III partially double-blinded, randomised, multinational, active-controlled trial in both previously vaccinated and unvaccinated adults to determine the safety and immunogenicity of AZD2816, a vaccine for the prevention of COVID-19 caused by variant strains of the SARS-CoV-2 virus.<\/p>\n\n\n\n<p>Trial participants aged 18 years or over who are SARS-CoV-2 nucleocapsid seronegative will be randomised to minimise group differences in terms of age, gender and the presence of comorbidities. Participants will receive intramuscular administration of either&nbsp;<em>Vaxzevria&nbsp;<\/em>(5 \u00d710<sup>10<\/sup>&nbsp;viral particles) or AZD2816 (5 \u00d710<sup>10<\/sup>&nbsp;viral particles). In addition, seropositive participants will be enrolled, with a cap of 10% of the seronegative population, to support exploratory analysis.<\/p>\n\n\n\n<p><strong>AZD2816<br><\/strong>AZD2816 has been built using the same adenoviral vector platform as with&nbsp;<em>Vaxzevria<\/em>, with minor genetic alterations to the spike protein based on the Beta (B.1.351, South African) variant. The Beta variant vaccine contains ten changes across the spike protein, many of which are also seen in other variants of concern, and which lead to effects such as, reduced ability of antibodies induced against the original virus to block cell entry (K417N, E484K, N501Y); increased infectivity compared to the original virus (D614G); reduced sensitivity of neutralising antibodies to the original virus (L452R). These modifications are only minor and in all other ways the two vaccines are the same.<\/p>\n\n\n\n<p><strong><em>Vaxzevria<\/em>, formally AZD1222<br><\/strong><em>Vaxzevria&nbsp;<\/em>was co-invented by the University of Oxford and its spin-out company, Vaccitech. It uses a replication-deficient chimpanzee viral vector based on a weakened version of a common cold virus (adenovirus) that causes infections in chimpanzees and contains the genetic material of the SARS-CoV-2 virus spike protein. After vaccination, the surface spike protein is produced, priming the immune system to attack the SARS-CoV-2 virus if it later infects the body.<\/p>\n\n\n\n<p>The vaccine has been granted a conditional marketing authorisation or emergency use in more than 80\u00a0countries across six continents.\u00a0More than 600 million doses of\u00a0COVID-19 Vaccine AstraZeneca\u00a0have been supplied to 170 countries worldwide, including more than 100 countries through the COVAX Facility. In the UK,\u00a0<em>Vaxzevria\u00a0<\/em>is known as\u00a0<em>COVID-19 Vaccine AstraZeneca<\/em>.<\/p>\n\n\n<style>.kb-image1779_7e482b-6e .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image1779_7e482b-6e size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"392\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/IQVIA.jpg\" alt=\"IQVIA\" class=\"kb-img wp-image-1780\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/IQVIA.jpg 1024w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/IQVIA-300x115.jpg 300w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/IQVIA-768x294.jpg 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-1779_a17485-fc .kt-block-spacer{height:80px;}.wp-block-kadence-spacer.kt-block-spacer-1779_a17485-fc .kt-divider{border-top-width:3px;height:1px;border-top-color:#F59F68;width:100%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-1779_a17485-fc\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><hr class=\"kt-divider\"\/><\/div><\/div>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-icon__arrow-right\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/cirg\/news\">SEE All News &amp; Events<span class=\"wp-block-button__link-icon\" aria-hidden=\"true\"><svg viewBox='0 0 16 11' xmlns='http:\/\/www.w3.org\/2000\/svg'><polygon points='0 4.7 13.1180124 4.7 9.44099379 1 10.4347826 0 16 5.5 10.4347826 11 9.44099379 10 13.1180124 6.3 0 6.3'><\/polygon><\/svg><\/span><\/a><\/div>\n<\/div>\n<\/div><\/div>\n\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>AZD2816 is a modified version of the Oxford\/AstraZeneca COVID-19 vaccine, that has been made specific for the Beta SARS CoV-2 variant<\/p>\n","protected":false},"author":3,"featured_media":1778,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[15],"class_list":["post-1779","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"rttpg_featured_image_url":{"full":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/Jenner_Institute_by_John_Cairns_20.11.20.jpg",768,576,false],"landscape":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/Jenner_Institute_by_John_Cairns_20.11.20.jpg",768,576,false],"portraits":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/Jenner_Institute_by_John_Cairns_20.11.20.jpg",768,576,false],"thumbnail":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/Jenner_Institute_by_John_Cairns_20.11.20-150x150.jpg",150,150,true],"medium":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/Jenner_Institute_by_John_Cairns_20.11.20-300x225.jpg",300,225,true],"large":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/Jenner_Institute_by_John_Cairns_20.11.20.jpg",768,576,false],"1536x1536":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/Jenner_Institute_by_John_Cairns_20.11.20.jpg",768,576,false],"2048x2048":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/Jenner_Institute_by_John_Cairns_20.11.20.jpg",768,576,false],"post_slider_thumbnail":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/Jenner_Institute_by_John_Cairns_20.11.20.jpg",768,576,false]},"rttpg_author":{"display_name":"st3vi3b0y","author_link":"https:\/\/apps.nhslothian.scot\/cirg\/author\/stephenharris\/"},"rttpg_comment":0,"rttpg_category":"<a href=\"https:\/\/apps.nhslothian.scot\/cirg\/category\/news\/\" rel=\"category tag\">News and Events<\/a>","rttpg_excerpt":"AZD2816 is a modified version of the Oxford\/AstraZeneca COVID-19 vaccine, that has been made specific for the Beta SARS CoV-2 variant","_links":{"self":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/posts\/1779","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/comments?post=1779"}],"version-history":[{"count":1,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/posts\/1779\/revisions"}],"predecessor-version":[{"id":1781,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/posts\/1779\/revisions\/1781"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/media\/1778"}],"wp:attachment":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/media?parent=1779"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/categories?post=1779"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}