{"id":1738,"date":"2022-03-02T19:19:00","date_gmt":"2022-03-02T19:19:00","guid":{"rendered":"https:\/\/apps.nhslothian.scot\/cirg\/?p=1738"},"modified":"2025-03-02T19:19:44","modified_gmt":"2025-03-02T19:19:44","slug":"new-research-publications","status":"publish","type":"post","link":"https:\/\/apps.nhslothian.scot\/cirg\/new-research-publications\/","title":{"rendered":"New Research Publications"},"content":{"rendered":"<style>.kb-row-layout-id1738_1136e5-96 > .kt-row-column-wrap{align-content:center;}:where(.kb-row-layout-id1738_1136e5-96 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:center;}.kb-row-layout-id1738_1136e5-96 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);max-width:1520px;padding-top:60px;padding-right:60px;padding-bottom:100px;padding-left:60px;min-height:450px;grid-template-columns:repeat(2, minmax(0, 1fr));}.kb-row-layout-id1738_1136e5-96 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1738_1136e5-96 > .kt-row-column-wrap{row-gap:var(--global-kb-gap-md, 2rem);padding-bottom:130px;grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id1738_1136e5-96 > .kt-row-column-wrap{row-gap:var(--global-kb-gap-md, 2rem);padding-right:15px;padding-bottom:150px;padding-left:15px;grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1738_1136e5-96 alignfull has-dark-accent-background-color kt-row-has-bg fullstretch wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-row kt-mobile-layout-row kt-row-valign-middle kb-theme-content-width\">\n<style>.kadence-column1738_054712-66 > .kt-inside-inner-col{display:flex;}.kadence-column1738_054712-66 > .kt-inside-inner-col,.kadence-column1738_054712-66 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1738_054712-66 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1738_054712-66 > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}.kadence-column1738_054712-66 > .kt-inside-inner-col > .kb-image-is-ratio-size{align-self:stretch;}.kadence-column1738_054712-66 > .kt-inside-inner-col > .wp-block-kadence-advancedgallery{align-self:stretch;}.kadence-column1738_054712-66 > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column1738_054712-66{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1738_054712-66{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1738_054712-66 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1738_054712-66 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1738_054712-66{position:relative;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column1738_054712-66{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1738_054712-66{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1738_054712-66 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column1738_054712-66 > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}}@media all and (max-width: 767px){.kt-row-column-wrap > .kadence-column1738_054712-66{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1738_054712-66{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1738_054712-66 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1738_054712-66 > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1738_054712-66\"><div class=\"kt-inside-inner-col\"><figure class=\"wp-block-post-featured-image\"><img loading=\"lazy\" decoding=\"async\" width=\"880\" height=\"660\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/CIRG-Post-Logo.png\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image default-featured-img\" alt=\"CIRG Post Logo\" style=\"border-radius:12px;object-fit:cover;\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/CIRG-Post-Logo.png 880w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/CIRG-Post-Logo-300x225.png 300w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/CIRG-Post-Logo-768x576.png 768w\" sizes=\"auto, (max-width: 880px) 100vw, 880px\" \/><\/figure><\/div><\/div>\n\n\n<style>.kadence-column1738_581fcb-9c > .kt-inside-inner-col{display:flex;}.kadence-column1738_581fcb-9c > .kt-inside-inner-col,.kadence-column1738_581fcb-9c > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1738_581fcb-9c > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1738_581fcb-9c > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}.kadence-column1738_581fcb-9c > .kt-inside-inner-col > .kb-image-is-ratio-size{align-self:stretch;}.kadence-column1738_581fcb-9c > .kt-inside-inner-col > .wp-block-kadence-advancedgallery{align-self:stretch;}.kadence-column1738_581fcb-9c > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column1738_581fcb-9c{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1738_581fcb-9c{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1738_581fcb-9c > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1738_581fcb-9c > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1738_581fcb-9c{position:relative;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column1738_581fcb-9c{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1738_581fcb-9c{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1738_581fcb-9c > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column1738_581fcb-9c > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}}@media all and (max-width: 767px){.kt-row-column-wrap > .kadence-column1738_581fcb-9c{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1738_581fcb-9c{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1738_581fcb-9c > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1738_581fcb-9c > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1738_581fcb-9c\"><div class=\"kt-inside-inner-col\"><h1 style=\"margin-right:30px;margin-left:30px;\" class=\"has-text-align-center has-link-color alignwide wp-elements-fcb699291ef6430427119bc2d1307555 wp-block-post-title has-text-color has-standard-white-color\">New Research Publications<\/h1>\n\n<div class=\"has-text-align-center has-link-color cirg-screen-excerpt wp-elements-a8508ab0214aaef08ded30a066c8b76c wp-block-post-excerpt has-text-color has-standard-white-color\"><p class=\"wp-block-post-excerpt__excerpt\">Two recently published papers authored by CIRG members <\/p><\/div>\n\n<div style=\"font-style:normal;font-weight:700;text-transform:uppercase; border-radius:50px; padding-top:9px;padding-bottom:9px;padding-left:20px;padding-right:20px;\" class=\"has-text-align-center has-link-color cirg-news-page-date wp-elements-a1f8281b758fa992bda8a3d771af56d2 wp-block-post-date has-text-color has-standard-white-color has-background has-accent-plum-background-color\"><time datetime=\"2022-03-02T19:19:00+00:00\">02 March 2022<\/time><\/div><\/div><\/div>\n\n<\/div><\/div>\n\n<style>.kb-row-layout-id1738_13310f-26 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id1738_13310f-26 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id1738_13310f-26 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);max-width:1280px;margin-left:auto;margin-right:auto;padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, 1fr);}.kb-row-layout-id1738_13310f-26 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1738_13310f-26 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id1738_13310f-26 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1738_13310f-26 alignnone cirg-news-wrapper wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-1-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column1738_c9a682-b1 > .kt-inside-inner-col{display:flex;}.kadence-column1738_c9a682-b1 > .kt-inside-inner-col{padding-top:35px;padding-right:30px;padding-bottom:40px;padding-left:30px;}.kadence-column1738_c9a682-b1 > .kt-inside-inner-col,.kadence-column1738_c9a682-b1 > .kt-inside-inner-col:before{border-top-left-radius:10px;border-top-right-radius:10px;border-bottom-right-radius:10px;border-bottom-left-radius:10px;}.kadence-column1738_c9a682-b1 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1738_c9a682-b1 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1738_c9a682-b1 > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column1738_c9a682-b1{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1738_c9a682-b1{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1738_c9a682-b1 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1738_c9a682-b1 > .kt-inside-inner-col{background-color:#ffffff;}.kadence-column1738_c9a682-b1 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1738_c9a682-b1{position:relative;}.kadence-column1738_c9a682-b1, .kt-inside-inner-col > .kadence-column1738_c9a682-b1:not(.specificity){margin-top:-70px;margin-bottom:15px;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column1738_c9a682-b1{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1738_c9a682-b1{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1738_c9a682-b1 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column1738_c9a682-b1 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kt-row-column-wrap > .kadence-column1738_c9a682-b1{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1738_c9a682-b1{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1738_c9a682-b1 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1738_c9a682-b1 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1738_c9a682-b1\"><div class=\"kt-inside-inner-col\">\n<p>We are pleased to share newly published research authored by CIRG members Oliver Koch, Claire Mackintosh, David Dockrell, Kate Templeton and Sin\u00e9ad Plant. A brief outline of the two studies is provided below, as well as a link to access the full publication.<\/p>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-1738_c6bc25-8d .kt-block-spacer{height:60px;}.wp-block-kadence-spacer.kt-block-spacer-1738_c6bc25-8d .kt-divider{border-top-width:1px;height:1px;border-top-color:#846576;width:80%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-1738_c6bc25-8d\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><hr class=\"kt-divider\"\/><\/div><\/div>\n\n\n\n<p><a href=\"https:\/\/www.thelancet.com\/journals\/ebiom\/article\/PIIS2352-3964(22)00040-8\/fulltext\" target=\"_blank\" rel=\"noreferrer noopener\">Randomised controlled trial of intravenous nafamostat mesylate in COVID pneumonitis: Phase 1b\/2a experimental study to investigate safety, Pharmacokinetics and Pharmacodynamics<\/a><\/p>\n\n\n\n<p><strong>Background<\/strong><br>Many repurposed drugs have progressed rapidly to Phase 2 and 3 trials in COVID19 without characterisation of Pharmacokinetics \/Pharmacodynamics including safety data. One such drug is nafamostat mesylate.<\/p>\n\n\n\n<p><strong>Methods<\/strong><br>We present the findings of a phase Ib\/IIa open label, platform randomised controlled trial of intravenous nafamostat in hospitalised patients with confirmed COVID-19 pneumonitis. Patients were assigned randomly to standard of care (SoC), nafamostat or an alternative therapy. Nafamostat was administered as an intravenous infusion at a dose of 0.2 mg\/kg\/h for a maximum of seven days. The analysis population included those who received any dose of the trial drug and all patients randomised to SoC. The primary outcomes of our trial were the safety and tolerability of intravenous nafamostat as an add on therapy for patients hospitalised with COVID-19 pneumonitis.<\/p>\n\n\n\n<p><strong>Findings<\/strong><br>Data is reported from 42 patients, 21 of which were randomly assigned to receive intravenous nafamostat. 86% of nafamostat-treated patients experienced at least one AE compared to 57% of the SoC group. The nafamostat group were significantly more likely to experience at least one AE (posterior mean odds ratio 5.17, 95% credible interval (CI) 1.10 \u2013 26.05) and developed significantly higher plasma creatinine levels (posterior mean difference 10.57 micromol\/L, 95% CI 2.43\u201318.92). An average longer hospital stay was observed in nafamostat patients, alongside a lower rate of oxygen free days (rate ratio 0.55\u201395% CI 0.31\u20130.99, respectively). There were no other statistically significant differences in endpoints between nafamostat and SoC. PK data demonstrated that intravenous nafamostat was rapidly broken down to inactive metabolites. We observed no significant anticoagulant effects in thromboelastometry.<\/p>\n\n\n\n<p><strong>Interpretation<\/strong><br>In hospitalised patients with COVID-19, we did not observe evidence of anti-inflammatory, anticoagulant or antiviral activity with intravenous nafamostat, and there were additional adverse events.<\/p>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-1738_3da81f-73 .kt-block-spacer{height:60px;}.wp-block-kadence-spacer.kt-block-spacer-1738_3da81f-73 .kt-divider{border-top-width:1px;height:1px;border-top-color:#846576;width:80%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-1738_3da81f-73\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><hr class=\"kt-divider\"\/><\/div><\/div>\n\n\n\n<p><a href=\"https:\/\/bmjopen.bmj.com\/content\/11\/12\/e054442.long\" target=\"_blank\" rel=\"noreferrer noopener\">Evaluation of new or repurposed treatments for COVID-19: protocol for the phase Ib\/IIa DEFINE trial platform<\/a><\/p>\n\n\n\n<p id=\"p-3\"><strong>Introduction<\/strong><br>COVID-19 is a new viral-induced pneumonia caused by infection with a novel coronavirus, SARS-CoV-2. At present, there are few proven effective treatments. This early-phase experimental medicine protocol describes an overarching and adaptive trial designed to provide safety data in patients with COVID-19, pharmacokinetic (PK)\/pharmacodynamic (PD) information and exploratory biological surrogates of efficacy, which may support further development and deployment of candidate therapies in larger scale trials of patients positive for COVID-19.<\/p>\n\n\n\n<p id=\"p-4\"><strong>Methods and analysis<\/strong><br>Define is an ongoing exploratory multicentre-platform, open-label, randomised study. Patients positive for COVID-19 will be recruited from the following cohorts: (a) community cases; (b) hospitalised patients with evidence of COVID-19 pneumonitis; and (c) hospitalised patients requiring assisted ventilation. The cohort recruited from will be dependent on the experimental therapy, its route of administration and mechanism of action. Randomisation will be computer generated in a 1:1:n ratio. Twenty patients will be recruited per arm for the initial two arms. This is permitted to change as per the experimental therapy. The primary statistical analyses are concerned with the safety of candidate agents as add-on therapy to standard of care in patients with COVID-19. Secondary analysis will assess the following variables during treatment period: (1) the response of key exploratory biomarkers; (2) change in WHO ordinal scale and National Early Warning Score 2 (NEWS2) score; (3) oxygen requirements; (4) viral load; (5) duration of hospital stay; (6) PK\/PD; and (7) changes in key coagulation pathways.<\/p>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-1738_1ae125-48 .kt-block-spacer{height:80px;}.wp-block-kadence-spacer.kt-block-spacer-1738_1ae125-48 .kt-divider{border-top-width:3px;height:1px;border-top-color:#F59F68;width:100%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-1738_1ae125-48\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><hr class=\"kt-divider\"\/><\/div><\/div>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-icon__arrow-right\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/cirg\/news\">SEE All News &amp; Events<span class=\"wp-block-button__link-icon\" aria-hidden=\"true\"><svg viewBox='0 0 16 11' xmlns='http:\/\/www.w3.org\/2000\/svg'><polygon points='0 4.7 13.1180124 4.7 9.44099379 1 10.4347826 0 16 5.5 10.4347826 11 9.44099379 10 13.1180124 6.3 0 6.3'><\/polygon><\/svg><\/span><\/a><\/div>\n<\/div>\n<\/div><\/div>\n\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Two recently published papers authored by CIRG members<\/p>\n","protected":false},"author":3,"featured_media":1081,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[15],"class_list":["post-1738","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"rttpg_featured_image_url":{"full":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/CIRG-Post-Logo.png",880,660,false],"landscape":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/CIRG-Post-Logo.png",880,660,false],"portraits":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/CIRG-Post-Logo.png",880,660,false],"thumbnail":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/CIRG-Post-Logo-150x150.png",150,150,true],"medium":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/CIRG-Post-Logo-300x225.png",300,225,true],"large":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/CIRG-Post-Logo.png",880,660,false],"1536x1536":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/CIRG-Post-Logo.png",880,660,false],"2048x2048":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/CIRG-Post-Logo.png",880,660,false],"post_slider_thumbnail":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/CIRG-Post-Logo.png",880,660,false]},"rttpg_author":{"display_name":"st3vi3b0y","author_link":"https:\/\/apps.nhslothian.scot\/cirg\/author\/stephenharris\/"},"rttpg_comment":0,"rttpg_category":"<a href=\"https:\/\/apps.nhslothian.scot\/cirg\/category\/news\/\" rel=\"category tag\">News and Events<\/a>","rttpg_excerpt":"Two recently published papers authored by CIRG members","_links":{"self":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/posts\/1738","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/comments?post=1738"}],"version-history":[{"count":1,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/posts\/1738\/revisions"}],"predecessor-version":[{"id":1739,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/posts\/1738\/revisions\/1739"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/media\/1081"}],"wp:attachment":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/media?parent=1738"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/categories?post=1738"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}