{"id":1736,"date":"2022-03-03T19:05:00","date_gmt":"2022-03-03T19:05:00","guid":{"rendered":"https:\/\/apps.nhslothian.scot\/cirg\/?p=1736"},"modified":"2025-03-02T19:06:36","modified_gmt":"2025-03-02T19:06:36","slug":"new-pre-print-from-the-recovery-trial","status":"publish","type":"post","link":"https:\/\/apps.nhslothian.scot\/cirg\/new-pre-print-from-the-recovery-trial\/","title":{"rendered":"New Pre-Print from the RECOVERY Trial"},"content":{"rendered":"<style>.kb-row-layout-id1736_6e493a-28 > .kt-row-column-wrap{align-content:center;}:where(.kb-row-layout-id1736_6e493a-28 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:center;}.kb-row-layout-id1736_6e493a-28 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);max-width:1520px;padding-top:60px;padding-right:60px;padding-bottom:100px;padding-left:60px;min-height:450px;grid-template-columns:repeat(2, minmax(0, 1fr));}.kb-row-layout-id1736_6e493a-28 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1736_6e493a-28 > .kt-row-column-wrap{row-gap:var(--global-kb-gap-md, 2rem);padding-bottom:130px;grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id1736_6e493a-28 > .kt-row-column-wrap{row-gap:var(--global-kb-gap-md, 2rem);padding-right:15px;padding-bottom:150px;padding-left:15px;grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1736_6e493a-28 alignfull has-dark-accent-background-color kt-row-has-bg fullstretch wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-row kt-mobile-layout-row kt-row-valign-middle kb-theme-content-width\">\n<style>.kadence-column1736_408df2-56 > .kt-inside-inner-col{display:flex;}.kadence-column1736_408df2-56 > .kt-inside-inner-col,.kadence-column1736_408df2-56 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1736_408df2-56 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1736_408df2-56 > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}.kadence-column1736_408df2-56 > .kt-inside-inner-col > .kb-image-is-ratio-size{align-self:stretch;}.kadence-column1736_408df2-56 > .kt-inside-inner-col > .wp-block-kadence-advancedgallery{align-self:stretch;}.kadence-column1736_408df2-56 > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column1736_408df2-56{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1736_408df2-56{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1736_408df2-56 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1736_408df2-56 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1736_408df2-56{position:relative;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column1736_408df2-56{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1736_408df2-56{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1736_408df2-56 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column1736_408df2-56 > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}}@media all and (max-width: 767px){.kt-row-column-wrap > .kadence-column1736_408df2-56{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1736_408df2-56{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1736_408df2-56 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1736_408df2-56 > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1736_408df2-56\"><div class=\"kt-inside-inner-col\"><figure class=\"wp-block-post-featured-image\"><img loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"576\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/RECOVERY-project.jpg\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image\" alt=\"RECOVERY project\" style=\"border-radius:12px;object-fit:cover;\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/RECOVERY-project.jpg 768w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/RECOVERY-project-300x225.jpg 300w\" sizes=\"auto, (max-width: 768px) 100vw, 768px\" \/><\/figure><\/div><\/div>\n\n\n<style>.kadence-column1736_b35acd-eb > .kt-inside-inner-col{display:flex;}.kadence-column1736_b35acd-eb > .kt-inside-inner-col,.kadence-column1736_b35acd-eb > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1736_b35acd-eb > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1736_b35acd-eb > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}.kadence-column1736_b35acd-eb > .kt-inside-inner-col > .kb-image-is-ratio-size{align-self:stretch;}.kadence-column1736_b35acd-eb > .kt-inside-inner-col > .wp-block-kadence-advancedgallery{align-self:stretch;}.kadence-column1736_b35acd-eb > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column1736_b35acd-eb{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1736_b35acd-eb{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1736_b35acd-eb > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1736_b35acd-eb > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1736_b35acd-eb{position:relative;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column1736_b35acd-eb{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1736_b35acd-eb{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1736_b35acd-eb > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column1736_b35acd-eb > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}}@media all and (max-width: 767px){.kt-row-column-wrap > .kadence-column1736_b35acd-eb{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1736_b35acd-eb{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1736_b35acd-eb > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1736_b35acd-eb > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1736_b35acd-eb\"><div class=\"kt-inside-inner-col\"><h1 style=\"margin-right:30px;margin-left:30px;\" class=\"has-text-align-center has-link-color alignwide wp-elements-fcb699291ef6430427119bc2d1307555 wp-block-post-title has-text-color has-standard-white-color\">New Pre-Print from the RECOVERY Trial<\/h1>\n\n<div class=\"has-text-align-center has-link-color cirg-screen-excerpt wp-elements-a8508ab0214aaef08ded30a066c8b76c wp-block-post-excerpt has-text-color has-standard-white-color\"><p class=\"wp-block-post-excerpt__excerpt\">New Results from the RECOVERY Trial suggest that baricitinib can reduce the risk of death in hospitalised COVID-19 patients <\/p><\/div>\n\n<div style=\"font-style:normal;font-weight:700;text-transform:uppercase; border-radius:50px; padding-top:9px;padding-bottom:9px;padding-left:20px;padding-right:20px;\" class=\"has-text-align-center has-link-color cirg-news-page-date wp-elements-a1f8281b758fa992bda8a3d771af56d2 wp-block-post-date has-text-color has-standard-white-color has-background has-accent-plum-background-color\"><time datetime=\"2022-03-03T19:05:00+00:00\">03 March 2022<\/time><\/div><\/div><\/div>\n\n<\/div><\/div>\n\n<style>.kb-row-layout-id1736_65d589-62 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id1736_65d589-62 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id1736_65d589-62 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);max-width:1280px;margin-left:auto;margin-right:auto;padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, 1fr);}.kb-row-layout-id1736_65d589-62 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1736_65d589-62 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id1736_65d589-62 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1736_65d589-62 alignnone cirg-news-wrapper wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-1-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column1736_e0bf59-a6 > .kt-inside-inner-col{display:flex;}.kadence-column1736_e0bf59-a6 > .kt-inside-inner-col{padding-top:35px;padding-right:30px;padding-bottom:40px;padding-left:30px;}.kadence-column1736_e0bf59-a6 > .kt-inside-inner-col,.kadence-column1736_e0bf59-a6 > .kt-inside-inner-col:before{border-top-left-radius:10px;border-top-right-radius:10px;border-bottom-right-radius:10px;border-bottom-left-radius:10px;}.kadence-column1736_e0bf59-a6 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1736_e0bf59-a6 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1736_e0bf59-a6 > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column1736_e0bf59-a6{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1736_e0bf59-a6{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1736_e0bf59-a6 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1736_e0bf59-a6 > .kt-inside-inner-col{background-color:#ffffff;}.kadence-column1736_e0bf59-a6 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1736_e0bf59-a6{position:relative;}.kadence-column1736_e0bf59-a6, .kt-inside-inner-col > .kadence-column1736_e0bf59-a6:not(.specificity){margin-top:-70px;margin-bottom:15px;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column1736_e0bf59-a6{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1736_e0bf59-a6{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1736_e0bf59-a6 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column1736_e0bf59-a6 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kt-row-column-wrap > .kadence-column1736_e0bf59-a6{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1736_e0bf59-a6{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1736_e0bf59-a6 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1736_e0bf59-a6 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1736_e0bf59-a6\"><div class=\"kt-inside-inner-col\">\n<p>This exciting new pre-print from the RECOVERY trial team shares the findings from the baricitinib arm of the trial.<\/p>\n\n\n\n<p>Many CIRG members, led by local PI\u00a0<a href=\"\/cirg\/people\/dr-oliver-koch\/\">Dr Oliver Koch<\/a>, have been part of the team recruiting to the RECOVERY trial over the last two years at the Edinburgh site. This innovative study, conducted across the U.K., has helped prove (and disprove) the effectiveness of new COVID-19 therapies to reduce mortality in patients hostpitalised with COVID-19.<\/p>\n\n\n\n<p>You can read the abstract below, and <a href=\"https:\/\/www.medrxiv.org\/content\/10.1101\/2022.03.02.22271623v1\" target=\"_blank\" rel=\"noreferrer noopener\">access the full pre-print\u00a0here<\/a>. Note that as this is a pre-print, it has not yet been peer-reviewed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading alignwide\">Abstract<\/h2>\n\n\n\n<p>Background: We evaluated the use of baricitinib, a Janus kinase (JAK) 1\/2 inhibitor, for the treatment of patients admitted to hospital because of COVID-19. Methods: This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple possible treatments in patients hospitalised for COVID-19. Eligible and consenting patients were randomly allocated (1:1) to either usual standard of care alone (usual care group) or usual care plus baricitinib 4 mg once daily by mouth for 10 days or until discharge if sooner (baricitinib group). The primary outcome was 28-day mortality assessed in the intention-to-treat population. A meta-analysis was conducted that included the results from the RECOVERY trial and all previous randomised controlled trials of baricitinib or other JAK inhibitor in patients hospitalised with COVID-19. Findings: Between 2 February 2021 and 29 December 2021, 8156 patients were randomly allocated to receive usual care plus baricitinib versus usual care alone. At randomisation, 95% of patients were receiving corticosteroids and 23% receiving tocilizumab (with planned use within the next 24 hours recorded for a further 9%). Overall, 513 (12%) of 4148 patients allocated to baricitinib versus 546 (14%) of 4008 patients allocated to usual care died within 28 days (age-adjusted rate ratio 0.87; 95% CI 0.77-0.98; p=0.026). This 13% proportional reduction in mortality was somewhat smaller than that seen in a meta-analysis of 8 previous trials of a JAK inhibitor (involving 3732 patients and 425 deaths) in which allocation to a JAK inhibitor was associated with a 43% proportional reduction in mortality (rate ratio 0.57; 95% CI 0.45-0.72). Including the results from RECOVERY into an updated meta-analysis of all 9 completed trials (involving 11,888 randomised patients and 1484 deaths) allocation to baricitinib or other JAK inhibitor was associated with a 20% proportional reduction in mortality (rate ratio 0.80; 95% CI 0.71-0.89; p&lt;0.001). In RECOVERY, there was no significant excess in death or infection due to non-COVID-19 causes and no excess of thrombosis, or other safety outcomes. Interpretation: In patients hospitalised for COVID-19, baricitinib significantly reduced the risk of death but the size of benefit was somewhat smaller than that suggested by previous trials. The total randomised evidence to date suggests that JAK inhibitors (chiefly baricitinib) reduce mortality in patients hospitalised for COVID-19 by about one-fifth.<\/p>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-1736_54a75c-7f .kt-block-spacer{height:80px;}.wp-block-kadence-spacer.kt-block-spacer-1736_54a75c-7f .kt-divider{border-top-width:3px;height:1px;border-top-color:#F59F68;width:100%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-1736_54a75c-7f\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><hr class=\"kt-divider\"\/><\/div><\/div>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-icon__arrow-right\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/cirg\/news\">SEE All News &amp; Events<span class=\"wp-block-button__link-icon\" aria-hidden=\"true\"><svg viewBox='0 0 16 11' xmlns='http:\/\/www.w3.org\/2000\/svg'><polygon points='0 4.7 13.1180124 4.7 9.44099379 1 10.4347826 0 16 5.5 10.4347826 11 9.44099379 10 13.1180124 6.3 0 6.3'><\/polygon><\/svg><\/span><\/a><\/div>\n<\/div>\n<\/div><\/div>\n\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>New Results from the RECOVERY Trial suggest that baricitinib can reduce the risk of death in hospitalised COVID-19 patients<\/p>\n","protected":false},"author":3,"featured_media":1735,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[15],"class_list":["post-1736","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"rttpg_featured_image_url":{"full":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/RECOVERY-project.jpg",768,576,false],"landscape":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/RECOVERY-project.jpg",768,576,false],"portraits":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/RECOVERY-project.jpg",768,576,false],"thumbnail":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/RECOVERY-project-150x150.jpg",150,150,true],"medium":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/RECOVERY-project-300x225.jpg",300,225,true],"large":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/RECOVERY-project.jpg",768,576,false],"1536x1536":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/RECOVERY-project.jpg",768,576,false],"2048x2048":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/RECOVERY-project.jpg",768,576,false],"post_slider_thumbnail":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/RECOVERY-project.jpg",768,576,false]},"rttpg_author":{"display_name":"st3vi3b0y","author_link":"https:\/\/apps.nhslothian.scot\/cirg\/author\/stephenharris\/"},"rttpg_comment":0,"rttpg_category":"<a href=\"https:\/\/apps.nhslothian.scot\/cirg\/category\/news\/\" rel=\"category tag\">News and Events<\/a>","rttpg_excerpt":"New Results from the RECOVERY Trial suggest that baricitinib can reduce the risk of death in hospitalised COVID-19 patients","_links":{"self":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/posts\/1736","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/comments?post=1736"}],"version-history":[{"count":1,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/posts\/1736\/revisions"}],"predecessor-version":[{"id":1737,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/posts\/1736\/revisions\/1737"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/media\/1735"}],"wp:attachment":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/media?parent=1736"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/categories?post=1736"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}