{"id":1727,"date":"2022-08-17T17:14:00","date_gmt":"2022-08-17T16:14:00","guid":{"rendered":"https:\/\/apps.nhslothian.scot\/cirg\/?p=1727"},"modified":"2025-03-02T17:14:38","modified_gmt":"2025-03-02T17:14:38","slug":"two-new-studies-recruiting","status":"publish","type":"post","link":"https:\/\/apps.nhslothian.scot\/cirg\/two-new-studies-recruiting\/","title":{"rendered":"Two New Studies Recruiting"},"content":{"rendered":"<style>.kb-row-layout-id1727_4791f2-27 > .kt-row-column-wrap{align-content:center;}:where(.kb-row-layout-id1727_4791f2-27 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:center;}.kb-row-layout-id1727_4791f2-27 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);max-width:1520px;padding-top:60px;padding-right:60px;padding-bottom:100px;padding-left:60px;min-height:450px;grid-template-columns:repeat(2, minmax(0, 1fr));}.kb-row-layout-id1727_4791f2-27 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1727_4791f2-27 > .kt-row-column-wrap{row-gap:var(--global-kb-gap-md, 2rem);padding-bottom:130px;grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id1727_4791f2-27 > .kt-row-column-wrap{row-gap:var(--global-kb-gap-md, 2rem);padding-right:15px;padding-bottom:150px;padding-left:15px;grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1727_4791f2-27 alignfull has-dark-accent-background-color kt-row-has-bg fullstretch wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-row kt-mobile-layout-row kt-row-valign-middle kb-theme-content-width\">\n<style>.kadence-column1727_aa5a9b-0c > .kt-inside-inner-col{display:flex;}.kadence-column1727_aa5a9b-0c > .kt-inside-inner-col,.kadence-column1727_aa5a9b-0c > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1727_aa5a9b-0c > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1727_aa5a9b-0c > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}.kadence-column1727_aa5a9b-0c > .kt-inside-inner-col > .kb-image-is-ratio-size{align-self:stretch;}.kadence-column1727_aa5a9b-0c > .kt-inside-inner-col > .wp-block-kadence-advancedgallery{align-self:stretch;}.kadence-column1727_aa5a9b-0c > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column1727_aa5a9b-0c{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1727_aa5a9b-0c{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1727_aa5a9b-0c > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1727_aa5a9b-0c > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1727_aa5a9b-0c{position:relative;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column1727_aa5a9b-0c{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1727_aa5a9b-0c{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1727_aa5a9b-0c > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column1727_aa5a9b-0c > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}}@media all and (max-width: 767px){.kt-row-column-wrap > .kadence-column1727_aa5a9b-0c{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1727_aa5a9b-0c{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1727_aa5a9b-0c > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1727_aa5a9b-0c > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1727_aa5a9b-0c\"><div class=\"kt-inside-inner-col\"><figure class=\"wp-block-post-featured-image\"><img loading=\"lazy\" decoding=\"async\" width=\"880\" height=\"660\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/CIRG-Post-Logo.png\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image default-featured-img\" alt=\"CIRG Post Logo\" style=\"border-radius:12px;object-fit:cover;\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/CIRG-Post-Logo.png 880w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/CIRG-Post-Logo-300x225.png 300w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/CIRG-Post-Logo-768x576.png 768w\" sizes=\"auto, (max-width: 880px) 100vw, 880px\" \/><\/figure><\/div><\/div>\n\n\n<style>.kadence-column1727_57db61-f6 > .kt-inside-inner-col{display:flex;}.kadence-column1727_57db61-f6 > .kt-inside-inner-col,.kadence-column1727_57db61-f6 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1727_57db61-f6 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1727_57db61-f6 > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}.kadence-column1727_57db61-f6 > .kt-inside-inner-col > .kb-image-is-ratio-size{align-self:stretch;}.kadence-column1727_57db61-f6 > .kt-inside-inner-col > .wp-block-kadence-advancedgallery{align-self:stretch;}.kadence-column1727_57db61-f6 > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column1727_57db61-f6{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1727_57db61-f6{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1727_57db61-f6 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1727_57db61-f6 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1727_57db61-f6{position:relative;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column1727_57db61-f6{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1727_57db61-f6{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1727_57db61-f6 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column1727_57db61-f6 > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}}@media all and (max-width: 767px){.kt-row-column-wrap > .kadence-column1727_57db61-f6{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1727_57db61-f6{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1727_57db61-f6 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1727_57db61-f6 > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1727_57db61-f6\"><div class=\"kt-inside-inner-col\"><h1 style=\"margin-right:30px;margin-left:30px;\" class=\"has-text-align-center has-link-color alignwide wp-elements-fcb699291ef6430427119bc2d1307555 wp-block-post-title has-text-color has-standard-white-color\">Two New Studies Recruiting<\/h1>\n\n<div class=\"has-text-align-center has-link-color cirg-screen-excerpt wp-elements-a8508ab0214aaef08ded30a066c8b76c wp-block-post-excerpt has-text-color has-standard-white-color\"><p class=\"wp-block-post-excerpt__excerpt\">CIRG has started recruiting to two new exciting studies <\/p><\/div>\n\n<div style=\"font-style:normal;font-weight:700;text-transform:uppercase; border-radius:50px; padding-top:9px;padding-bottom:9px;padding-left:20px;padding-right:20px;\" class=\"has-text-align-center has-link-color cirg-news-page-date wp-elements-a1f8281b758fa992bda8a3d771af56d2 wp-block-post-date has-text-color has-standard-white-color has-background has-accent-plum-background-color\"><time datetime=\"2022-08-17T17:14:00+01:00\">17 August 2022<\/time><\/div><\/div><\/div>\n\n<\/div><\/div>\n\n<style>.kb-row-layout-id1727_f49542-a6 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id1727_f49542-a6 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id1727_f49542-a6 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);max-width:1280px;margin-left:auto;margin-right:auto;padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, 1fr);}.kb-row-layout-id1727_f49542-a6 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1727_f49542-a6 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id1727_f49542-a6 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1727_f49542-a6 alignnone cirg-news-wrapper wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-1-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column1727_bea583-e1 > .kt-inside-inner-col{display:flex;}.kadence-column1727_bea583-e1 > .kt-inside-inner-col{padding-top:35px;padding-right:30px;padding-bottom:40px;padding-left:30px;}.kadence-column1727_bea583-e1 > .kt-inside-inner-col,.kadence-column1727_bea583-e1 > .kt-inside-inner-col:before{border-top-left-radius:10px;border-top-right-radius:10px;border-bottom-right-radius:10px;border-bottom-left-radius:10px;}.kadence-column1727_bea583-e1 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1727_bea583-e1 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1727_bea583-e1 > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column1727_bea583-e1{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1727_bea583-e1{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1727_bea583-e1 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1727_bea583-e1 > .kt-inside-inner-col{background-color:#ffffff;}.kadence-column1727_bea583-e1 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1727_bea583-e1{position:relative;}.kadence-column1727_bea583-e1, .kt-inside-inner-col > .kadence-column1727_bea583-e1:not(.specificity){margin-top:-70px;margin-bottom:15px;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column1727_bea583-e1{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1727_bea583-e1{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1727_bea583-e1 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column1727_bea583-e1 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kt-row-column-wrap > .kadence-column1727_bea583-e1{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1727_bea583-e1{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1727_bea583-e1 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1727_bea583-e1 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1727_bea583-e1\"><div class=\"kt-inside-inner-col\">\n<p>The CIRG team are excited to start recruiting to two new studies into innovative new treatments.<\/p>\n\n\n\n<p>The\u00a0<a href=\"\/cirg\/projects\/eagle-1-btz116577\">EAGLE-1<\/a>\u00a0study will compare the efficacy and safety of gepotidacin to intramuscular ceftriaxone plus oral azithromycin in patients with uncomplicated gonorrhoea caused by the bacterium NG. Gepotidacin (GSK2140944) is the first in a new class of antibiotics, called triazaacenaphthylene topoisomerase inhibitors, developed at GSK in 2007 with a novel \u201cdual targeting\u201d mechanism of action (MOA) and oral formulation. Its MOA is distinct from any currently approved antibiotic.<\/p>\n\n\n\n<p>The\u00a0<a href=\"\/cirg\/projects\/rio\/\">RIO<\/a>\u00a0study will trial a combination of the two long-acting broadly neutralising antibodies, 3BNC117-LS and 10-1074-LS. It is hypothesised that these recently developed bNAbs will induce a period of virological remission even when when ART is stopped. The combination of 3BNC117 and 10-1074 has already been tested in humans in a single-arm proof of principle study that suggested that this combination can impose full, sustained viral suppression in the absence of ART. The bNAbs will now be tested in a randomised clinical trial powered to answer the question of whether these they are effective at controlling HIV replication in the absence of ART.<\/p>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-1727_81418f-f8 .kt-block-spacer{height:80px;}.wp-block-kadence-spacer.kt-block-spacer-1727_81418f-f8 .kt-divider{border-top-width:3px;height:1px;border-top-color:#F59F68;width:100%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-1727_81418f-f8\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><hr class=\"kt-divider\"\/><\/div><\/div>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-icon__arrow-right\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/cirg\/news\">SEE All News &amp; Events<span class=\"wp-block-button__link-icon\" aria-hidden=\"true\"><svg viewBox='0 0 16 11' xmlns='http:\/\/www.w3.org\/2000\/svg'><polygon points='0 4.7 13.1180124 4.7 9.44099379 1 10.4347826 0 16 5.5 10.4347826 11 9.44099379 10 13.1180124 6.3 0 6.3'><\/polygon><\/svg><\/span><\/a><\/div>\n<\/div>\n<\/div><\/div>\n\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>CIRG has started recruiting to two new exciting studies<\/p>\n","protected":false},"author":3,"featured_media":1081,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[15],"class_list":["post-1727","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"rttpg_featured_image_url":{"full":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/CIRG-Post-Logo.png",880,660,false],"landscape":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/CIRG-Post-Logo.png",880,660,false],"portraits":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/CIRG-Post-Logo.png",880,660,false],"thumbnail":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/CIRG-Post-Logo-150x150.png",150,150,true],"medium":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/CIRG-Post-Logo-300x225.png",300,225,true],"large":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/CIRG-Post-Logo.png",880,660,false],"1536x1536":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/CIRG-Post-Logo.png",880,660,false],"2048x2048":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/CIRG-Post-Logo.png",880,660,false],"post_slider_thumbnail":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/02\/CIRG-Post-Logo.png",880,660,false]},"rttpg_author":{"display_name":"st3vi3b0y","author_link":"https:\/\/apps.nhslothian.scot\/cirg\/author\/stephenharris\/"},"rttpg_comment":0,"rttpg_category":"<a href=\"https:\/\/apps.nhslothian.scot\/cirg\/category\/news\/\" rel=\"category tag\">News and Events<\/a>","rttpg_excerpt":"CIRG has started recruiting to two new exciting studies","_links":{"self":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/posts\/1727","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/comments?post=1727"}],"version-history":[{"count":1,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/posts\/1727\/revisions"}],"predecessor-version":[{"id":1728,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/posts\/1727\/revisions\/1728"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/media\/1081"}],"wp:attachment":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/media?parent=1727"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/categories?post=1727"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}