{"id":1725,"date":"2022-10-07T17:01:00","date_gmt":"2022-10-07T16:01:00","guid":{"rendered":"https:\/\/apps.nhslothian.scot\/cirg\/?p=1725"},"modified":"2025-03-02T17:02:39","modified_gmt":"2025-03-02T17:02:39","slug":"article-publication","status":"publish","type":"post","link":"https:\/\/apps.nhslothian.scot\/cirg\/article-publication\/","title":{"rendered":"Article Publication"},"content":{"rendered":"<style>.kb-row-layout-id1725_796c1c-88 > .kt-row-column-wrap{align-content:center;}:where(.kb-row-layout-id1725_796c1c-88 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:center;}.kb-row-layout-id1725_796c1c-88 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);max-width:1520px;padding-top:60px;padding-right:60px;padding-bottom:100px;padding-left:60px;min-height:450px;grid-template-columns:repeat(2, minmax(0, 1fr));}.kb-row-layout-id1725_796c1c-88 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1725_796c1c-88 > .kt-row-column-wrap{row-gap:var(--global-kb-gap-md, 2rem);padding-bottom:130px;grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id1725_796c1c-88 > .kt-row-column-wrap{row-gap:var(--global-kb-gap-md, 2rem);padding-right:15px;padding-bottom:150px;padding-left:15px;grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1725_796c1c-88 alignfull has-dark-accent-background-color kt-row-has-bg fullstretch wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-row kt-mobile-layout-row kt-row-valign-middle kb-theme-content-width\">\n<style>.kadence-column1725_add28e-70 > .kt-inside-inner-col{display:flex;}.kadence-column1725_add28e-70 > .kt-inside-inner-col,.kadence-column1725_add28e-70 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1725_add28e-70 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1725_add28e-70 > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}.kadence-column1725_add28e-70 > .kt-inside-inner-col > .kb-image-is-ratio-size{align-self:stretch;}.kadence-column1725_add28e-70 > .kt-inside-inner-col > .wp-block-kadence-advancedgallery{align-self:stretch;}.kadence-column1725_add28e-70 > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column1725_add28e-70{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1725_add28e-70{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1725_add28e-70 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1725_add28e-70 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1725_add28e-70{position:relative;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column1725_add28e-70{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1725_add28e-70{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1725_add28e-70 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column1725_add28e-70 > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}}@media all and (max-width: 767px){.kt-row-column-wrap > .kadence-column1725_add28e-70{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1725_add28e-70{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1725_add28e-70 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1725_add28e-70 > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1725_add28e-70\"><div class=\"kt-inside-inner-col\"><figure class=\"wp-block-post-featured-image\"><img loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"576\" src=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/JVH-cover-graphic.jpg\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image\" alt=\"JVH cover graphic\" style=\"border-radius:12px;object-fit:cover;\" srcset=\"https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/JVH-cover-graphic.jpg 768w, https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/JVH-cover-graphic-300x225.jpg 300w\" sizes=\"auto, (max-width: 768px) 100vw, 768px\" \/><\/figure><\/div><\/div>\n\n\n<style>.kadence-column1725_346e14-f8 > .kt-inside-inner-col{display:flex;}.kadence-column1725_346e14-f8 > .kt-inside-inner-col,.kadence-column1725_346e14-f8 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1725_346e14-f8 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1725_346e14-f8 > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}.kadence-column1725_346e14-f8 > .kt-inside-inner-col > .kb-image-is-ratio-size{align-self:stretch;}.kadence-column1725_346e14-f8 > .kt-inside-inner-col > .wp-block-kadence-advancedgallery{align-self:stretch;}.kadence-column1725_346e14-f8 > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column1725_346e14-f8{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1725_346e14-f8{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1725_346e14-f8 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1725_346e14-f8 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1725_346e14-f8{position:relative;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column1725_346e14-f8{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1725_346e14-f8{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1725_346e14-f8 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column1725_346e14-f8 > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}}@media all and (max-width: 767px){.kt-row-column-wrap > .kadence-column1725_346e14-f8{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1725_346e14-f8{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1725_346e14-f8 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1725_346e14-f8 > .kt-inside-inner-col{flex-direction:column;justify-content:center;align-items:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1725_346e14-f8\"><div class=\"kt-inside-inner-col\"><h1 style=\"margin-right:30px;margin-left:30px;\" class=\"has-text-align-center has-link-color alignwide wp-elements-fcb699291ef6430427119bc2d1307555 wp-block-post-title has-text-color has-standard-white-color\">Article Publication<\/h1>\n\n<div class=\"has-text-align-center has-link-color cirg-screen-excerpt wp-elements-a8508ab0214aaef08ded30a066c8b76c wp-block-post-excerpt has-text-color has-standard-white-color\"><p class=\"wp-block-post-excerpt__excerpt\">A fascinating paper recently published in The Journal of Viral Hepatitis. The paper features WGH&#8217;s Senior Clinical Pharmacist, Katherine Davidson as one of the paper&#8217;s authors <\/p><\/div>\n\n<div style=\"font-style:normal;font-weight:700;text-transform:uppercase; border-radius:50px; padding-top:9px;padding-bottom:9px;padding-left:20px;padding-right:20px;\" class=\"has-text-align-center has-link-color cirg-news-page-date wp-elements-a1f8281b758fa992bda8a3d771af56d2 wp-block-post-date has-text-color has-standard-white-color has-background has-accent-plum-background-color\"><time datetime=\"2022-10-07T17:01:00+01:00\">07 October 2022<\/time><\/div><\/div><\/div>\n\n<\/div><\/div>\n\n<style>.kb-row-layout-id1725_862f98-87 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id1725_862f98-87 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id1725_862f98-87 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);max-width:1280px;margin-left:auto;margin-right:auto;padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, 1fr);}.kb-row-layout-id1725_862f98-87 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1725_862f98-87 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id1725_862f98-87 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1725_862f98-87 alignnone cirg-news-wrapper wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-1-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column1725_d878fd-16 > .kt-inside-inner-col{display:flex;}.kadence-column1725_d878fd-16 > .kt-inside-inner-col{padding-top:35px;padding-right:30px;padding-bottom:40px;padding-left:30px;}.kadence-column1725_d878fd-16 > .kt-inside-inner-col,.kadence-column1725_d878fd-16 > .kt-inside-inner-col:before{border-top-left-radius:10px;border-top-right-radius:10px;border-bottom-right-radius:10px;border-bottom-left-radius:10px;}.kadence-column1725_d878fd-16 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1725_d878fd-16 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1725_d878fd-16 > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column1725_d878fd-16{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1725_d878fd-16{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1725_d878fd-16 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1725_d878fd-16 > .kt-inside-inner-col{background-color:#ffffff;}.kadence-column1725_d878fd-16 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1725_d878fd-16{position:relative;}.kadence-column1725_d878fd-16, .kt-inside-inner-col > .kadence-column1725_d878fd-16:not(.specificity){margin-top:-70px;margin-bottom:15px;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column1725_d878fd-16{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1725_d878fd-16{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1725_d878fd-16 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column1725_d878fd-16 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kt-row-column-wrap > .kadence-column1725_d878fd-16{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1725_d878fd-16{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column1725_d878fd-16 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column1725_d878fd-16 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1725_d878fd-16\"><div class=\"kt-inside-inner-col\">\n<p>Abstract<\/p>\n\n\n\n<p>Treatment for hepatitis C virus (HCV) with direct-acting antivirals (DAA) is advantageous over previous treatment options due to high efficacy, short treatment duration, and relatively few drug interactions. Similarly, direct oral anticoagulants (DOAC) are generally preferred over warfarin for the management of thrombosis and atrial fibrillation due to a favourable safety profile. Direct-acting antivirals inhibit DOAC transport through P-glycoprotein inhibition leading to a theoretical increase in bleeding risk. We evaluated the incidence of bleeding in patients who received concurrent DAA and DOAC therapy and stratified the analysis based on the patient\u2019s cirrhosis status. We conducted a multicenter, retrospective cohort study to evaluate bleeding in patients with HCV and cirrhosis compared to patients with HCV without cirrhosis. Patients receiving at least 1\u2009month of overlapping DAA and DOAC therapy between May 2017 and August 2020 at 11 medical centers in the United Kingdom and three medical centers in the United States were included. Charts were manually reviewed to identify baseline characteristics as well as thromboembolic or bleeding events. Bleeding events were categorized as major bleeding (MB) and clinically relevant non-major bleeding (CRNMB). Of 204 total patients, 36 patients (18%) had cirrhosis and 168 patients (82%) did not have cirrhosis. The majority of patients were male (79%) and Caucasian (75%). Sofosbuvir\/velpatasvir (32%) and rivaroxaban (57%) were the most commonly prescribed DAA and DOAC, respectively. Leading indications for anticoagulation included thrombosis (75%) and atrial fibrillation (21%). There were three MB events (1.5%) all of which occurred in patients with additional risk factors (age over 65 and on antiplatelet therapy) and no CRNMB occurred while on DOAC and DAA therapy. Of the three MB, one occurred in a patient with cirrhosis and two in patients without cirrhosis, RR 1.23 (0.56\u20132.76). In conclusion, in this multicenter cohort study of concurrent DAA and DOAC use, MB was uncommon and there was no CRNMB. There was no significant difference in bleeding events among patients with cirrhosis compared to those without cirrhosis. These findings support the use of DAA among patients requiring DOAC.<\/p>\n\n\n\n<p><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.13750\" target=\"_blank\" rel=\"noreferrer noopener\">Read the full article online<\/a><\/p>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-1725_e2fbaf-65 .kt-block-spacer{height:80px;}.wp-block-kadence-spacer.kt-block-spacer-1725_e2fbaf-65 .kt-divider{border-top-width:3px;height:1px;border-top-color:#F59F68;width:100%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-1725_e2fbaf-65\"><div class=\"kt-block-spacer kt-block-spacer-halign-center\"><hr class=\"kt-divider\"\/><\/div><\/div>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-icon__arrow-right\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/cirg\/news\">SEE All News &amp; Events<span class=\"wp-block-button__link-icon\" aria-hidden=\"true\"><svg viewBox='0 0 16 11' xmlns='http:\/\/www.w3.org\/2000\/svg'><polygon points='0 4.7 13.1180124 4.7 9.44099379 1 10.4347826 0 16 5.5 10.4347826 11 9.44099379 10 13.1180124 6.3 0 6.3'><\/polygon><\/svg><\/span><\/a><\/div>\n<\/div>\n<\/div><\/div>\n\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>A fascinating paper recently published in The Journal of Viral Hepatitis. The paper features WGH&#8217;s Senior Clinical Pharmacist, Katherine Davidson as one of the paper&#8217;s authors<\/p>\n","protected":false},"author":3,"featured_media":1724,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[15],"class_list":["post-1725","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"rttpg_featured_image_url":{"full":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/JVH-cover-graphic.jpg",768,576,false],"landscape":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/JVH-cover-graphic.jpg",768,576,false],"portraits":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/JVH-cover-graphic.jpg",768,576,false],"thumbnail":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/JVH-cover-graphic-150x150.jpg",150,150,true],"medium":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/JVH-cover-graphic-300x225.jpg",300,225,true],"large":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/JVH-cover-graphic.jpg",768,576,false],"1536x1536":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/JVH-cover-graphic.jpg",768,576,false],"2048x2048":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/JVH-cover-graphic.jpg",768,576,false],"post_slider_thumbnail":["https:\/\/apps.nhslothian.scot\/cirg\/wp-content\/uploads\/sites\/5\/2025\/03\/JVH-cover-graphic.jpg",768,576,false]},"rttpg_author":{"display_name":"st3vi3b0y","author_link":"https:\/\/apps.nhslothian.scot\/cirg\/author\/stephenharris\/"},"rttpg_comment":0,"rttpg_category":"<a href=\"https:\/\/apps.nhslothian.scot\/cirg\/category\/news\/\" rel=\"category tag\">News and Events<\/a>","rttpg_excerpt":"A fascinating paper recently published in The Journal of Viral Hepatitis. The paper features WGH's Senior Clinical Pharmacist, Katherine Davidson as one of the paper's authors","_links":{"self":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/posts\/1725","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/comments?post=1725"}],"version-history":[{"count":1,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/posts\/1725\/revisions"}],"predecessor-version":[{"id":1726,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/posts\/1725\/revisions\/1726"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/media\/1724"}],"wp:attachment":[{"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/media?parent=1725"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/apps.nhslothian.scot\/cirg\/wp-json\/wp\/v2\/categories?post=1725"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}